Motif ID: Pparg_Rxrg

Z-value: 1.434

Transcription factors associated with Pparg_Rxrg:

Gene SymbolEntrez IDGene Name
Pparg ENSMUSG00000000440.6 Pparg
Rxrg ENSMUSG00000015843.4 Rxrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgmm10_v2_chr1_+_167618246_167618309-0.019.6e-01Click!


Activity profile for motif Pparg_Rxrg.

activity profile for motif Pparg_Rxrg


Sorted Z-values histogram for motif Pparg_Rxrg

Sorted Z-values for motif Pparg_Rxrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Pparg_Rxrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 17.063 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr5_-_115119277 12.955 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr17_+_35049966 11.976 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr11_+_80300866 10.129 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr4_+_126556935 8.795 ENSMUST00000048391.8
 Clspn
claspin
chr13_-_24761861 8.746 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr9_+_118506226 8.740 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr4_-_126736236 8.064 ENSMUST00000048194.7
 Tfap2e
transcription factor AP-2, epsilon
chr3_+_87948666 8.052 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr11_+_61485431 7.668 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr2_-_79456750 7.351 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr1_-_138847579 7.245 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr11_-_100354040 7.197 ENSMUST00000173630.1
 Hap1
huntingtin-associated protein 1
chr4_+_126556994 6.752 ENSMUST00000147675.1
 Clspn
claspin
chr4_+_9269285 6.628 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr14_+_54476100 6.305 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr6_+_83137089 5.542 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr2_+_126556128 5.386 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr10_+_128790903 5.369 ENSMUST00000026411.6
 Mmp19
matrix metallopeptidase 19
chr14_-_67715585 5.276 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 360 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 24.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
5.7 17.1 GO:0006553 lysine metabolic process(GO:0006553)
1.9 16.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 16.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 13.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 11.4 GO:0015914 phospholipid transport(GO:0015914)
2.6 10.2 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.0 10.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.4 9.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.0 9.3 GO:0071493 cellular response to UV-B(GO:0071493)
1.1 8.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 8.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.2 8.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.8 8.1 GO:0042573 retinoic acid metabolic process(GO:0042573)
1.8 7.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
1.4 7.2 GO:0035262 gonad morphogenesis(GO:0035262)
1.4 7.2 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 6.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 6.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.6 6.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 26.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 24.4 GO:0005694 chromosome(GO:0005694)
0.1 12.0 GO:0005814 centriole(GO:0005814)
0.8 10.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.9 9.6 GO:0097149 centralspindlin complex(GO:0097149)
0.1 8.5 GO:0000922 spindle pole(GO:0000922)
0.0 8.3 GO:0005759 mitochondrial matrix(GO:0005759)
2.6 7.7 GO:0071953 elastic fiber(GO:0071953)
0.2 7.6 GO:0034707 chloride channel complex(GO:0034707)
1.8 7.0 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 6.8 GO:0001650 fibrillar center(GO:0001650)
0.1 6.6 GO:0016459 myosin complex(GO:0016459)
1.1 5.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 5.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.9 GO:0016607 nuclear speck(GO:0016607)
0.0 4.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.5 4.5 GO:0030478 actin cap(GO:0030478)
0.2 4.4 GO:0000145 exocyst(GO:0000145)
0.0 4.1 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 17.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.6 15.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 14.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 13.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.2 12.8 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 12.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 10.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 9.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3 9.2 GO:0016918 retinal binding(GO:0016918)
1.0 9.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 8.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 8.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 8.4 GO:0005548 phospholipid transporter activity(GO:0005548)
0.7 7.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 7.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 7.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 7.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 7.1 GO:0008430 selenium binding(GO:0008430)
0.2 7.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 7.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 34.8 PID_PLK1_PATHWAY PLK1 signaling events
0.4 18.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 14.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 9.0 ST_STAT3_PATHWAY STAT3 Pathway
0.1 7.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 6.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 4.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.1 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 3.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 3.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 3.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 2.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 25.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 12.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 9.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.5 8.7 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 7.4 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 6.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 6.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 6.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 5.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.7 5.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 5.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 5.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 4.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 4.6 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 4.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 4.1 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 3.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing