Motif ID: Prdm1

Z-value: 1.173


Transcription factors associated with Prdm1:

Gene SymbolEntrez IDGene Name
Prdm1 ENSMUSG00000038151.6 Prdm1



Activity profile for motif Prdm1.

activity profile for motif Prdm1


Sorted Z-values histogram for motif Prdm1

Sorted Z-values for motif Prdm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prdm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137796350 8.629 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr4_-_154636831 7.778 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr3_+_145758674 7.284 ENSMUST00000029845.8
 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr2_-_105399286 7.185 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr9_-_107668967 6.864 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr5_+_3343893 6.856 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr19_+_36409719 6.683 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr9_+_38718263 6.603 ENSMUST00000001544.5
ENSMUST00000118144.1
 Vwa5a

von Willebrand factor A domain containing 5A

chr11_-_77894096 6.478 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_-_156674290 6.094 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr4_-_96591555 5.657 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr15_+_32920723 5.642 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr18_-_41951187 5.174 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chr14_+_65805832 5.167 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr11_-_82991829 4.945 ENSMUST00000092840.4
ENSMUST00000038211.5
 Slfn9

schlafen 9

chr7_-_102250086 4.778 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr3_-_107760221 4.667 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr2_+_116067213 4.654 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_-_117182623 4.648 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr14_+_65806066 4.371 ENSMUST00000139644.1
 Pbk
PDZ binding kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.5 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.2 8.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.1 8.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.7 7.3 GO:0006527 arginine catabolic process(GO:0006527)
1.4 6.9 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
1.0 6.9 GO:0044838 cell quiescence(GO:0044838)
0.4 6.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.2 6.5 GO:0006553 lysine metabolic process(GO:0006553)
1.9 5.7 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 5.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 5.0 GO:0015914 phospholipid transport(GO:0015914)
1.6 4.8 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.2 4.8 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 4.7 GO:0043010 camera-type eye development(GO:0043010)
0.9 4.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.5 4.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 4.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 4.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.0 4.0 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
1.0 4.0 GO:0090335 regulation of brown fat cell differentiation(GO:0090335)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.6 GO:0005925 focal adhesion(GO:0005925)
0.2 9.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 7.9 GO:0016235 aggresome(GO:0016235)
0.4 7.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 6.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 6.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
1.6 4.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 4.6 GO:0035371 microtubule plus-end(GO:0035371)
1.0 4.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 4.0 GO:0016607 nuclear speck(GO:0016607)
1.1 3.2 GO:0005588 collagen type V trimer(GO:0005588)
0.3 3.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 3.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 2.9 GO:0033269 internode region of axon(GO:0033269)
0.0 2.9 GO:0005844 polysome(GO:0005844)
0.4 2.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 2.7 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 8.9 GO:0033613 activating transcription factor binding(GO:0033613)
2.2 8.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.2 7.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
2.3 6.9 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
2.3 6.9 GO:0098770 FBXO family protein binding(GO:0098770)
1.6 6.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 6.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 6.0 GO:0003697 single-stranded DNA binding(GO:0003697)
1.7 5.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
1.6 4.8 GO:0004454 ketohexokinase activity(GO:0004454)
0.3 4.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 4.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6 4.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 4.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 4.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 3.9 GO:0008083 growth factor activity(GO:0008083)
0.0 3.7 GO:0030165 PDZ domain binding(GO:0030165)
0.7 3.5 GO:0000405 bubble DNA binding(GO:0000405)
0.2 3.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 PID_BARD1_PATHWAY BARD1 signaling events
0.1 6.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 6.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 4.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 4.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 4.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 3.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 3.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 6.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 5.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 4.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 4.4 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.2 4.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.2 3.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 3.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 3.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 3.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 2.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 1.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA