Motif ID: Prdm1
Z-value: 1.173
Transcription factors associated with Prdm1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Prdm1 | ENSMUSG00000038151.6 | Prdm1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.9 | 5.7 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
| 1.6 | 4.8 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625) |
| 1.5 | 4.5 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 1.4 | 6.9 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
| 1.1 | 3.2 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.1 | 8.4 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 1.0 | 4.0 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 1.0 | 4.0 | GO:0090335 | regulation of brown fat cell differentiation(GO:0090335) |
| 1.0 | 6.9 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.9 | 4.6 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.8 | 4.0 | GO:0090669 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669) |
| 0.8 | 1.5 | GO:1904430 | negative regulation of t-circle formation(GO:1904430) |
| 0.8 | 2.3 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.7 | 3.0 | GO:1902990 | leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.7 | 2.8 | GO:1903416 | response to glycoside(GO:1903416) |
| 0.7 | 7.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.6 | 2.5 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.6 | 1.8 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) |
| 0.6 | 1.7 | GO:0042196 | dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197) |
| 0.5 | 1.1 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.5 | 3.1 | GO:0021984 | adenohypophysis development(GO:0021984) |
| 0.5 | 2.6 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.5 | 1.5 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.5 | 2.9 | GO:0003383 | apical constriction(GO:0003383) |
| 0.5 | 2.7 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.4 | 0.8 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.4 | 1.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.4 | 6.8 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.4 | 4.1 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.4 | 1.1 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.4 | 3.3 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.4 | 1.1 | GO:0090289 | regulation of osteoclast proliferation(GO:0090289) |
| 0.3 | 2.7 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 0.3 | 2.4 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) protein K6-linked ubiquitination(GO:0085020) |
| 0.3 | 2.9 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.3 | 2.4 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.2 | 1.2 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.2 | 1.2 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.2 | 8.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.2 | 0.9 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.2 | 0.8 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
| 0.2 | 0.7 | GO:0000019 | regulation of mitotic recombination(GO:0000019) |
| 0.2 | 3.1 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.2 | 4.8 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.2 | 1.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 9.5 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.1 | 1.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 2.7 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 1.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 1.1 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.1 | 1.0 | GO:0061009 | common bile duct development(GO:0061009) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.9 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
| 0.1 | 0.4 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.1 | 4.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.8 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 5.0 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.3 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.1 | 0.4 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 0.1 | 0.6 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 1.0 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 0.4 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 0.1 | 0.7 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.1 | 0.4 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 0.4 | GO:0045065 | cytotoxic T cell differentiation(GO:0045065) |
| 0.1 | 0.6 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 3.5 | GO:0006289 | nucleotide-excision repair(GO:0006289) |
| 0.1 | 0.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.4 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 0.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.0 | 0.7 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.4 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 2.2 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.2 | GO:0060594 | mammary gland specification(GO:0060594) |
| 0.0 | 0.4 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 1.0 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.7 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.0 | 5.3 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
| 0.0 | 0.4 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 3.7 | GO:0045766 | positive regulation of angiogenesis(GO:0045766) |
| 0.0 | 0.2 | GO:0042126 | nitrate metabolic process(GO:0042126) |
| 0.0 | 0.2 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.3 | GO:0014842 | skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842) skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857) |
| 0.0 | 3.1 | GO:0051099 | positive regulation of binding(GO:0051099) |
| 0.0 | 2.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 1.0 | GO:0051972 | regulation of telomerase activity(GO:0051972) |
| 0.0 | 1.3 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
| 0.0 | 0.8 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 0.0 | 0.8 | GO:2001022 | positive regulation of response to DNA damage stimulus(GO:2001022) |
| 0.0 | 0.1 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 4.7 | GO:0043010 | camera-type eye development(GO:0043010) |
| 0.0 | 0.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.1 | GO:0071380 | cellular response to prostaglandin stimulus(GO:0071379) cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.0 | 0.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.6 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.1 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 1.1 | 3.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.0 | 4.0 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 1.0 | 3.0 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.4 | 7.0 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.4 | 2.4 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.4 | 2.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 1.5 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.4 | 2.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.4 | 2.9 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 3.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 0.9 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.3 | 2.0 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.2 | 0.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 9.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 7.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 1.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 1.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 4.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.9 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 1.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 6.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.5 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 6.7 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 2.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 6.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 0.4 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 0.6 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 1.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.7 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 2.9 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.2 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 6.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 12.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.1 | GO:0001939 | female pronucleus(GO:0001939) |
| 0.0 | 5.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.1 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.2 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 2.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.4 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 1.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 4.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.3 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.0 | 2.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.4 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.0 | 0.5 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.9 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
| 2.3 | 6.9 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 2.2 | 8.6 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 1.7 | 5.2 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 1.6 | 6.5 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 1.6 | 4.8 | GO:0004454 | ketohexokinase activity(GO:0004454) |
| 1.2 | 7.3 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 1.0 | 3.0 | GO:0032139 | DNA polymerase processivity factor activity(GO:0030337) dinucleotide insertion or deletion binding(GO:0032139) |
| 0.9 | 2.6 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.8 | 2.5 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.7 | 3.5 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.6 | 4.0 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.6 | 1.7 | GO:0019120 | hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651) |
| 0.4 | 3.2 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.4 | 1.1 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.4 | 4.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.4 | 2.8 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.3 | 3.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 0.8 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.3 | 4.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.3 | 4.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.2 | 1.2 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.2 | 0.8 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.2 | 3.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 3.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.2 | 4.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 2.3 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.2 | 3.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 0.8 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.2 | 1.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 1.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 0.9 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 0.1 | 3.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.7 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.1 | 6.1 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.1 | 0.3 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
| 0.1 | 2.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.6 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 8.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.2 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.1 | 1.1 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 1.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 1.0 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.1 | 0.3 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 2.3 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.1 | 0.4 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 0.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 2.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 6.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 1.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 0.2 | GO:0043546 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) molybdenum ion binding(GO:0030151) molybdopterin cofactor binding(GO:0043546) |
| 0.0 | 2.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 3.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 1.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.1 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209) |
| 0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.4 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 1.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 3.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 1.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 10.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.7 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.0 | 0.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.2 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 2.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.5 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.6 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.8 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.6 | GO:0030551 | cyclic nucleotide binding(GO:0030551) |
| 0.0 | 0.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 2.4 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.7 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 7.7 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.2 | 4.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 6.9 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.0 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 4.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 3.8 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 4.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.2 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.2 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.7 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 2.9 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 3.1 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 3.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.4 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.3 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.1 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.4 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.5 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.2 | 5.6 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 3.8 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 1.5 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 3.5 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 4.0 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.2 | 6.9 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 4.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.2 | 3.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 6.5 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 4.8 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.8 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 6.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.2 | 1.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 2.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 1.0 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 1.5 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.5 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 4.4 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.1 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 0.7 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 0.7 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 4.4 | REACTOME_METABOLISM_OF_CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.0 | 0.4 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.1 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
| 0.0 | 0.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.1 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
