ISMARA results: Prop1

Motif ID: Prop1

Z-value: 0.827

Transcription factors associated with Prop1:

Gene Symbol	Entrez ID	Gene Name
Prop1	ENSMUSG00000044542.3	Prop1

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Prop1	mm10_v2_chr11_-_50953745_50953768	-0.10	4.9e-01	Click!

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Top targets:

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_-_45470201	7.806	ENSMUST00000079390.6	Lin28b	lin-28 homolog B (C. elegans)
chr18_-_13972617	6.278	ENSMUST00000025288.7	Zfp521	zinc finger protein 521
chr10_-_64090241	5.749	ENSMUST00000133588.1	Lrrtm3	leucine rich repeat transmembrane neuronal 3
chr13_+_94875600	5.640	ENSMUST00000022195.10	Otp	orthopedia homolog (Drosophila)
chr9_+_118478344	5.427	ENSMUST00000035020.8	Eomes	eomesodermin homolog (Xenopus laevis)
chr9_+_118478182	4.816	ENSMUST00000111763.1	Eomes	eomesodermin homolog (Xenopus laevis)
chr4_-_110292719	4.687	ENSMUST00000106601.1	Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr18_-_66860458	4.608	ENSMUST00000057942.2	Mc4r	melanocortin 4 receptor
chr1_+_107511416	4.532	ENSMUST00000009356.4	Serpinb2	serine (or cysteine) peptidase inhibitor, clade B, member 2
chr10_-_64090265	4.515	ENSMUST00000105439.1	Lrrtm3	leucine rich repeat transmembrane neuronal 3
chr12_+_79297345	4.448	ENSMUST00000079533.5 ENSMUST00000171210.1	Rad51b	RAD51 homolog B
chr14_+_75455957	4.363	ENSMUST00000164848.1	Siah3	seven in absentia homolog 3 (Drosophila)
chr3_+_146121655	4.231	ENSMUST00000039450.4	Mcoln3	mucolipin 3
chr1_+_6734827	4.105	ENSMUST00000139838.1	St18	suppression of tumorigenicity 18
chr17_+_27556613	4.026	ENSMUST00000117600.1 ENSMUST00000114888.3	Hmga1	high mobility group AT-hook 1
chr17_+_27556668	3.947	ENSMUST00000117254.1 ENSMUST00000118570.1	Hmga1	high mobility group AT-hook 1
chr17_+_27556641	3.775	ENSMUST00000119486.1 ENSMUST00000118599.1	Hmga1	high mobility group AT-hook 1
chr3_+_94377432	3.478	ENSMUST00000107292.1	Rorc	RAR-related orphan receptor gamma
chr14_+_73237891	3.263	ENSMUST00000044405.6	Lpar6	lysophosphatidic acid receptor 6
chr4_+_109978004	3.193	ENSMUST00000061187.3	Dmrta2	doublesex and mab-3 related transcription factor like family A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 103 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.2	GO:0006284	base-excision repair(GO:0006284)
0.7	10.3	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004)
3.4	10.2	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.9	7.8	GO:0010587	miRNA catabolic process(GO:0010587)
0.8	6.6	GO:0072615	interleukin-17 secretion(GO:0072615)
0.4	5.6	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.1	5.5	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	4.7	GO:0043488	regulation of mRNA stability(GO:0043488)
0.9	4.6	GO:0002024	diet induced thermogenesis(GO:0002024)
0.9	4.4	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.7	4.4	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.3	4.1	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	3.9	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.1	3.3	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2	3.2	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.1	3.2	GO:0042491	auditory receptor cell differentiation(GO:0042491)
0.6	2.9	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.6	2.9	GO:0001661	conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.7	2.8	GO:1900623	positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.7	2.7	GO:0046552	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 52 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	11.7	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.9	5.5	GO:0031262	Ndc80 complex(GO:0031262)
0.3	4.7	GO:0042788	polysomal ribosome(GO:0042788)
0.9	4.4	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	3.5	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	2.9	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.6	2.4	GO:0008623	CHRAC(GO:0008623)
0.8	2.3	GO:1990423	RZZ complex(GO:1990423)
0.4	2.3	GO:0045179	apical cortex(GO:0045179)
0.4	2.1	GO:0044305	calyx of Held(GO:0044305)
0.0	2.0	GO:0043197	dendritic spine(GO:0043197)
0.2	1.9	GO:0002177	manchette(GO:0002177)
0.0	1.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.6	1.7	GO:0035061	interchromatin granule(GO:0035061)
0.0	1.7	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	1.6	GO:0070852	cell body fiber(GO:0070852)
0.0	1.4	GO:0070469	respiratory chain(GO:0070469)
0.0	1.3	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	1.3	GO:0005776	autophagosome(GO:0005776)
0.2	1.1	GO:0060293	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 75 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	12.4	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1	10.3	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.2	10.1	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	7.3	GO:0001047	core promoter binding(GO:0001047)
0.2	7.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.6	6.6	GO:0008142	oxysterol binding(GO:0008142)
0.1	4.7	GO:0017091	AU-rich element binding(GO:0017091)
1.5	4.6	GO:0004980	melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.6	4.4	GO:0000150	recombinase activity(GO:0000150)
0.0	4.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.5	3.3	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.9	2.8	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	2.7	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.1	2.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.8	2.3	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	2.3	GO:0017137	Rab GTPase binding(GO:0017137)
0.2	2.2	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.7	2.1	GO:0001565	phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.2	2.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	1.8	GO:0005496	steroid binding(GO:0005496)

Gene overrepresentation in C2:CP category:

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Showing 1 to 20 of 29 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.0	PID_IL4_2PATHWAY	IL4-mediated signaling events
0.2	10.2	PID_IL12_2PATHWAY	IL12-mediated signaling events
0.1	7.8	PID_MYC_ACTIV_PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	4.5	NABA_ECM_REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	3.9	PID_SYNDECAN_3_PATHWAY	Syndecan-3-mediated signaling events
0.0	1.5	PID_BMP_PATHWAY	BMP receptor signaling
0.0	1.4	PID_P38_ALPHA_BETA_PATHWAY	Regulation of p38-alpha and p38-beta
0.0	1.4	PID_RHOA_REG_PATHWAY	Regulation of RhoA activity
0.0	1.3	PID_P38_MK2_PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.3	PID_P53_DOWNSTREAM_PATHWAY	Direct p53 effectors
0.0	1.1	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway
0.1	1.0	PID_ERB_GENOMIC_PATHWAY	Validated nuclear estrogen receptor beta network
0.1	1.0	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.9	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.0	0.9	PID_HEDGEHOG_2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.9	PID_LIS1_PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.9	PID_HNF3B_PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.8	PID_ARF_3PATHWAY	Arf1 pathway
0.0	0.8	PID_SMAD2_3NUCLEAR_PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	0.8	PID_P73PATHWAY	p73 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 34 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	11.7	REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1	9.5	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	9.1	REACTOME_MITOTIC_PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	4.6	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	4.4	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	3.7	REACTOME_HEMOSTASIS	Genes involved in Hemostasis
0.2	2.8	REACTOME_HYALURONAN_METABOLISM	Genes involved in Hyaluronan metabolism
0.1	2.8	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT	Genes involved in Mitochondrial Protein Import
0.2	2.3	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	2.3	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	Genes involved in Aquaporin-mediated transport
0.0	2.2	REACTOME_PEPTIDE_CHAIN_ELONGATION	Genes involved in Peptide chain elongation
0.1	1.7	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	1.7	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	Genes involved in NRAGE signals death through JNK
0.5	1.6	REACTOME_SEROTONIN_RECEPTORS	Genes involved in Serotonin receptors
0.1	1.5	REACTOME_SIGNALING_BY_BMP	Genes involved in Signaling by BMP
0.1	1.4	REACTOME_P38MAPK_EVENTS	Genes involved in p38MAPK events
0.1	1.3	REACTOME_GLUCURONIDATION	Genes involved in Glucuronidation
0.1	0.9	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	0.9	REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.9	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)