Motif ID: Prop1
Z-value: 0.827
Transcription factors associated with Prop1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Prop1 | ENSMUSG00000044542.3 | Prop1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Prop1 | mm10_v2_chr11_-_50953745_50953768 | -0.10 | 4.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 10.2 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 0.9 | 4.6 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 0.9 | 4.4 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.9 | 7.8 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.8 | 6.6 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 0.7 | 4.4 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.7 | 2.8 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 10.3 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.7 | 2.7 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.6 | 2.9 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.6 | 2.9 | GO:0001661 | conditioned taste aversion(GO:0001661) amygdala development(GO:0021764) |
| 0.6 | 1.7 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.5 | 1.6 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
| 0.5 | 2.5 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.5 | 2.3 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.5 | 1.4 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.4 | 5.6 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.4 | 2.0 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.4 | 1.6 | GO:0010511 | regulation of phosphatidylinositol biosynthetic process(GO:0010511) |
| 0.4 | 2.3 | GO:0032439 | endosome localization(GO:0032439) |
| 0.4 | 1.1 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.4 | 1.5 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.4 | 2.2 | GO:0098734 | protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734) |
| 0.4 | 1.8 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
| 0.3 | 4.1 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.3 | 0.9 | GO:0090118 | receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) |
| 0.3 | 0.9 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
| 0.3 | 1.4 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
| 0.3 | 1.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.2 | 12.2 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.2 | 3.2 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 0.7 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.2 | 2.1 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.2 | 1.6 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.2 | 0.9 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.2 | 0.9 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.2 | 1.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 0.6 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 0.2 | 1.0 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.2 | 0.6 | GO:1905223 | epicardium morphogenesis(GO:1905223) |
| 0.2 | 1.1 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.2 | 1.1 | GO:0003383 | apical constriction(GO:0003383) |
| 0.2 | 0.5 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.2 | 0.7 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) negative regulation of t-circle formation(GO:1904430) |
| 0.2 | 1.1 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.2 | 0.5 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.2 | 0.8 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.1 | 3.3 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.1 | 1.6 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 5.5 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.1 | 0.8 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.7 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) positive regulation of beta-amyloid clearance(GO:1900223) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.1 | 0.7 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.1 | 1.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 0.4 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.1 | 1.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.9 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.1 | 0.7 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.1 | 0.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 0.9 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 2.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.3 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.1 | 0.7 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 0.8 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.1 | 0.4 | GO:0043137 | DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 0.2 | GO:2000670 | positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.1 | 0.5 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.1 | 1.8 | GO:0090201 | negative regulation of release of cytochrome c from mitochondria(GO:0090201) |
| 0.1 | 3.2 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
| 0.1 | 0.7 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.1 | 0.5 | GO:0019400 | glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400) |
| 0.1 | 0.5 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.1 | 1.0 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 0.8 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 0.2 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.1 | 0.9 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 1.0 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 0.2 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.0 | 4.7 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 2.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.2 | GO:0015817 | histidine transport(GO:0015817) |
| 0.0 | 0.5 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.2 | GO:0060161 | histone H4-R3 methylation(GO:0043985) positive regulation of dopamine receptor signaling pathway(GO:0060161) |
| 0.0 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.0 | 0.4 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.2 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 0.3 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.1 | GO:0036233 | glycine import(GO:0036233) |
| 0.0 | 3.9 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.7 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 2.3 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.0 | 0.6 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 1.3 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 2.2 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.0 | 0.7 | GO:0042775 | mitochondrial ATP synthesis coupled electron transport(GO:0042775) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.3 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.3 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 0.4 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.0 | 0.1 | GO:0051204 | protein insertion into mitochondrial membrane(GO:0051204) |
| 0.0 | 0.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 11.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.9 | 5.5 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.9 | 4.4 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.8 | 2.3 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.6 | 2.4 | GO:0008623 | CHRAC(GO:0008623) |
| 0.6 | 1.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.4 | 2.3 | GO:0045179 | apical cortex(GO:0045179) |
| 0.4 | 2.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.3 | 4.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 0.9 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.2 | 1.9 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 0.7 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.2 | 1.1 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.1 | 1.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.9 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 1.6 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 0.5 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 1.1 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.7 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 0.4 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 0.9 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 0.3 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.1 | 0.8 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.1 | 0.2 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.1 | 0.3 | GO:0030891 | VCB complex(GO:0030891) |
| 0.1 | 0.7 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 0.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 0.5 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 0.3 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.0 | 0.7 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 3.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 1.0 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 0.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.2 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 0.1 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 1.3 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.0 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 0.8 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.0 | 0.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.0 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.6 | GO:0008142 | oxysterol binding(GO:0008142) |
| 1.5 | 4.6 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 1.2 | 12.4 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.9 | 2.8 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.8 | 2.3 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.7 | 2.1 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.6 | 4.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.5 | 1.6 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.5 | 1.6 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.5 | 3.3 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.3 | 0.9 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
| 0.3 | 0.8 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.2 | 2.0 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.2 | 1.1 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.2 | 0.9 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.2 | 0.7 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.2 | 2.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 1.3 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.2 | 1.6 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.2 | 0.6 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.2 | 0.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 10.1 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 7.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 0.5 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 1.0 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 4.7 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 2.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 0.4 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.1 | 0.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 0.6 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 10.3 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 0.2 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.1 | 1.7 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 0.9 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 0.5 | GO:0019992 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) diacylglycerol binding(GO:0019992) |
| 0.1 | 0.5 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 0.4 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 0.8 | GO:0048038 | quinone binding(GO:0048038) |
| 0.1 | 0.2 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 0.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.4 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.0 | 0.1 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.0 | 0.2 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.0 | 0.6 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 1.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.4 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 2.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.2 | GO:0005290 | L-histidine transmembrane transporter activity(GO:0005290) |
| 0.0 | 0.5 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.0 | 0.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 1.1 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 1.1 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 7.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 4.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.8 | GO:0005496 | steroid binding(GO:0005496) |
| 0.0 | 1.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.0 | 0.7 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.8 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.0 | 0.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 1.1 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 1.0 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 11.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.2 | 10.2 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 7.8 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 1.0 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.0 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.4 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.9 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.6 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 4.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.8 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.3 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.9 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.3 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.7 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.1 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.4 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.5 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.3 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.8 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.5 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.4 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 11.7 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.5 | 1.6 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
| 0.2 | 2.3 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 2.8 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 1.3 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 9.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 0.9 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 0.6 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 9.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.4 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.1 | 0.7 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 0.7 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.7 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 0.9 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 0.5 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 4.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.8 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.5 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.5 | REACTOME_INTEGRATION_OF_ENERGY_METABOLISM | Genes involved in Integration of energy metabolism |
| 0.0 | 4.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 2.3 | REACTOME_AQUAPORIN_MEDIATED_TRANSPORT | Genes involved in Aquaporin-mediated transport |
| 0.0 | 0.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.7 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.5 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.3 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.5 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 2.2 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 3.7 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
| 0.0 | 0.8 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
