Motif ID: Prox1

Z-value: 0.509


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.542.3e-05Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_169747634 2.518 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 2.036 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_-_68954351 2.032 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr4_+_130913120 1.797 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_130913264 1.537 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr5_-_37824580 1.527 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr12_-_83487708 1.394 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr10_-_81025521 1.338 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr9_+_104569671 1.155 ENSMUST00000057742.8
 Cpne4
copine IV
chr6_+_58640536 1.088 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr6_-_131388417 1.064 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr7_-_127448993 0.937 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr10_-_81025406 0.909 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr7_-_127449109 0.895 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr2_-_92459709 0.862 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chrX_-_43274786 0.861 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr2_-_168734236 0.839 ENSMUST00000109175.2
 Atp9a
ATPase, class II, type 9A
chr4_+_42950369 0.768 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr4_-_36951223 0.718 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr11_+_19924403 0.702 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr18_-_20682963 0.637 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr17_+_37045963 0.613 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_-_19458494 0.606 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr11_+_19924354 0.602 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr10_-_81496313 0.575 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr18_-_67245818 0.574 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr5_+_139252343 0.548 ENSMUST00000130326.1
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr10_-_81496329 0.529 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr9_-_106247730 0.527 ENSMUST00000112524.2
ENSMUST00000074082.6
 Alas1

aminolevulinic acid synthase 1

chr12_-_36042476 0.502 ENSMUST00000020896.8
 Tspan13
tetraspanin 13
chr2_+_136891501 0.476 ENSMUST00000141463.1
 Slx4ip
SLX4 interacting protein
chr11_+_4986824 0.445 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr19_+_46056539 0.425 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
 Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr18_-_12819842 0.410 ENSMUST00000119043.1
 Osbpl1a
oxysterol binding protein-like 1A
chr17_+_37045980 0.410 ENSMUST00000174456.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_34959232 0.405 ENSMUST00000165202.1
ENSMUST00000172753.1
 Hspa1b

heat shock protein 1B

chr2_+_34406949 0.401 ENSMUST00000040459.4
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr19_+_41911851 0.399 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chrX_-_73966329 0.398 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr2_+_34406845 0.377 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr5_+_139211934 0.376 ENSMUST00000148772.1
ENSMUST00000110882.1
 Sun1

Sad1 and UNC84 domain containing 1

chr2_+_34406882 0.372 ENSMUST00000113123.1
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr4_+_59003121 0.368 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr17_+_27839974 0.351 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr8_+_85080939 0.344 ENSMUST00000140621.1
 BC056474
cDNA sequence BC056474
chr9_-_64726583 0.326 ENSMUST00000168366.1
 Rab11a
RAB11a, member RAS oncogene family
chr5_+_139252314 0.322 ENSMUST00000026976.5
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr12_-_40223149 0.312 ENSMUST00000171553.1
ENSMUST00000001672.5
 Ifrd1

interferon-related developmental regulator 1

chr14_-_55944536 0.296 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chr7_+_24081888 0.287 ENSMUST00000068975.3
 Zfp180
zinc finger protein 180
chr19_-_43524462 0.275 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr5_+_124112297 0.268 ENSMUST00000024470.6
ENSMUST00000119269.1
 Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr12_+_40222758 0.252 ENSMUST00000038121.4
 Gm7008
predicted gene 7008
chr7_-_126861648 0.248 ENSMUST00000129812.1
ENSMUST00000106342.1
 Ino80e

INO80 complex subunit E

chr11_-_120784183 0.246 ENSMUST00000026156.7
 Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_+_117835387 0.237 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr2_+_27009936 0.234 ENSMUST00000133807.1
 Cacfd1
calcium channel flower domain containing 1
chr17_-_34972124 0.232 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr8_-_70476911 0.231 ENSMUST00000066597.5
ENSMUST00000166976.1
 Klhl26

kelch-like 26

chr14_-_96519067 0.226 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr13_+_9276477 0.213 ENSMUST00000174552.1
 Dip2c
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_-_136891131 0.195 ENSMUST00000144275.1
 Mkks
McKusick-Kaufman syndrome
chr19_+_46152505 0.189 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr6_+_146796041 0.176 ENSMUST00000111639.1
 Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr9_-_110117303 0.169 ENSMUST00000136969.1
 Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr19_+_60144682 0.163 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr2_-_26910569 0.152 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr7_+_127777095 0.145 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr11_+_120784257 0.136 ENSMUST00000100134.3
 Gps1
G protein pathway suppressor 1
chr11_-_115933464 0.135 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr8_-_85080679 0.129 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83
chr7_-_80947499 0.118 ENSMUST00000120285.1
 Sec11a
SEC11 homolog A (S. cerevisiae)
chr1_-_160792908 0.105 ENSMUST00000028049.7
 Rabgap1l
RAB GTPase activating protein 1-like
chr6_+_122308684 0.086 ENSMUST00000007602.8
ENSMUST00000112610.1
 M6pr

mannose-6-phosphate receptor, cation dependent

chr15_-_89149557 0.076 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr2_+_36230426 0.075 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr2_-_136891363 0.054 ENSMUST00000028730.6
ENSMUST00000110089.2
 Mkks

McKusick-Kaufman syndrome

chr2_-_167062981 0.032 ENSMUST00000048988.7
 Znfx1
zinc finger, NFX1-type containing 1
chr2_+_128967383 0.027 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr17_-_83514311 0.026 ENSMUST00000167741.1
ENSMUST00000025095.7
 Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr5_-_138187177 0.023 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr8_-_85080652 0.016 ENSMUST00000152785.1
 Wdr83
WD repeat domain containing 83

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.5 1.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.4 1.1 GO:0019389 urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479)
0.4 1.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 1.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 1.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.4 GO:0019046 release from viral latency(GO:0019046)
0.1 0.9 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 2.0 GO:0042711 maternal behavior(GO:0042711)
0.1 0.9 GO:0030259 lipid glycosylation(GO:0030259)
0.1 1.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.4 GO:0090292 nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 2.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 1.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 3.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.4 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.1 GO:2001184 regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.1 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 3.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 1.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 1.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 2.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.4 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 1.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 1.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.5 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport