Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.742

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163313661_1633137100.672.8e-08Click!
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.456.5e-04Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478344 7.927 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 5.351 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_79386943 5.259 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr2_-_71546745 5.055 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr3_+_122419772 4.635 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr12_+_79297345 4.613 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr12_+_9029982 4.047 ENSMUST00000085741.1
 Ttc32
tetratricopeptide repeat domain 32
chr15_-_8710734 3.773 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrM_+_11734 3.642 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr10_-_42583628 3.480 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_-_101609033 3.290 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr9_+_35423582 3.279 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr12_+_117843489 3.254 ENSMUST00000021592.9
 Cdca7l
cell division cycle associated 7 like
chr17_+_78508063 3.164 ENSMUST00000024880.9
 Vit
vitrin
chr14_-_118052235 2.925 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_+_91257323 2.865 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr19_-_43912392 2.802 ENSMUST00000026209.4
 Dnmbp
dynamin binding protein
chr14_+_73237891 2.779 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr18_-_78206408 2.729 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_-_98339921 2.702 ENSMUST00000065793.5
 Phgdh
3-phosphoglycerate dehydrogenase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 13.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.6 6.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.7 5.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.8 4.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 4.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 4.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 4.2 GO:0006284 base-excision repair(GO:0006284)
0.1 3.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
1.2 3.6 GO:0006566 threonine metabolic process(GO:0006566)
0.4 3.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 3.5 GO:0007601 visual perception(GO:0007601)
0.4 3.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 3.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 3.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 2.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 2.8 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.9 2.7 GO:0071918 urea transmembrane transport(GO:0071918)
0.7 2.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.8 2.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.5 2.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0043197 dendritic spine(GO:0043197)
0.9 4.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.6 4.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 3.9 GO:0070469 respiratory chain(GO:0070469)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 2.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 2.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 2.0 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.3 1.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 1.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.1 6.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 6.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 5.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.9 5.3 GO:0019841 retinol binding(GO:0019841)
0.7 4.6 GO:0000150 recombinase activity(GO:0000150)
0.3 4.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 4.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 4.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 3.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.2 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.7 GO:0051287 NAD binding(GO:0051287)
0.1 2.6 GO:0017091 AU-rich element binding(GO:0017091)
0.3 2.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 2.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 7.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 5.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 3.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.0 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.7 PID_P73PATHWAY p73 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 4.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 4.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 3.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 3.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 2.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 2.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 2.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.4 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline