• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: Ptf1a

Z-value: 0.738

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr16_+_91269759	9.232	ENSMUST00000056882.5	Olig1	oligodendrocyte transcription factor 1
chr11_+_78324200	8.614	ENSMUST00000102478.3	Aldoc	aldolase C, fructose-bisphosphate
chr14_-_70207637	6.251	ENSMUST00000022682.5	Sorbs3	sorbin and SH3 domain containing 3
chr4_-_64046925	6.125	ENSMUST00000107377.3	Tnc	tenascin C
chr15_-_98004634	5.093	ENSMUST00000131560.1 ENSMUST00000088355.5	Col2a1	collagen, type II, alpha 1
chr7_-_79386943	5.029	ENSMUST00000053718.8 ENSMUST00000179243.1	Rlbp1	retinaldehyde binding protein 1
chr15_-_98004695	4.937	ENSMUST00000023123.8	Col2a1	collagen, type II, alpha 1
chr5_+_64970069	2.926	ENSMUST00000031080.8	Fam114a1	family with sequence similarity 114, member A1
chr9_-_21852603	2.253	ENSMUST00000034728.7	Dock6	dedicator of cytokinesis 6
chr19_+_16435616	2.116	ENSMUST00000025602.2	Gna14	guanine nucleotide binding protein, alpha 14
chr7_-_4532419	1.963	ENSMUST00000094897.4	Dnaaf3	dynein, axonemal assembly factor 3
chr2_+_31470207	1.750	ENSMUST00000102840.4	Ass1	argininosuccinate synthetase 1
chr19_+_7056731	1.569	ENSMUST00000040261.5	Macrod1	MACRO domain containing 1
chr10_-_126901315	1.329	ENSMUST00000026504.5 ENSMUST00000168520.1	Xrcc6bp1	XRCC6 binding protein 1
chr11_-_109611417	1.312	ENSMUST00000103060.3 ENSMUST00000047186.3 ENSMUST00000106689.1	Wipi1	WD repeat domain, phosphoinositide interacting 1
chr11_-_82871133	1.276	ENSMUST00000071152.7 ENSMUST00000108173.3	Rffl	ring finger and FYVE like domain containing protein
chr11_-_93965957	1.217	ENSMUST00000021220.3	Nme1	NME/NM23 nucleoside diphosphate kinase 1
chr7_-_140102367	1.183	ENSMUST00000142105.1	Fuom	fucose mutarotase
chr10_-_75932468	1.169	ENSMUST00000120281.1 ENSMUST00000000924.6	Mmp11	matrix metallopeptidase 11
chr9_-_112187898	1.061	ENSMUST00000178410.1 ENSMUST00000172380.3	Arpp21	cyclic AMP-regulated phosphoprotein, 21
chr10_-_77089428	1.040	ENSMUST00000156009.1	Col18a1	collagen, type XVIII, alpha 1
chr9_-_108597558	1.012	ENSMUST00000006853.5	P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr19_-_7241216	0.947	ENSMUST00000025675.9	Naa40	N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr17_-_27513341	0.931	ENSMUST00000118161.1	Grm4	glutamate receptor, metabotropic 4
chr11_+_40733936	0.904	ENSMUST00000127382.1	Nudcd2	NudC domain containing 2
chr11_-_6444352	0.804	ENSMUST00000093346.5 ENSMUST00000109737.2	H2afv	H2A histone family, member V
chr2_+_164769892	0.780	ENSMUST00000088248.6 ENSMUST00000001439.6	Ube2c	ubiquitin-conjugating enzyme E2C
chr4_+_152096719	0.772	ENSMUST00000105661.3 ENSMUST00000084115.3	Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr7_-_144582392	0.730	ENSMUST00000033394.7	Fadd	Fas (TNFRSF6)-associated via death domain
chr9_+_106477269	0.657	ENSMUST00000047721.8	Rrp9	RRP9, small subunit (SSU) processome component, homolog (yeast)
chr17_+_7925990	0.656	ENSMUST00000036370.7	Tagap	T cell activation Rho GTPase activating protein
chr3_-_141931523	0.652	ENSMUST00000106232.1	Bmpr1b	bone morphogenetic protein receptor, type 1B
chr11_+_40733639	0.632	ENSMUST00000020578.4	Nudcd2	NudC domain containing 2
chr10_+_86022189	0.615	ENSMUST00000120344.1 ENSMUST00000117597.1	Fbxo7	F-box protein 7
chr16_+_43762221	0.568	ENSMUST00000023390.4	Drd3	dopamine receptor D3
chr11_-_102185202	0.544	ENSMUST00000107156.2	Lsm12	LSM12 homolog (S. cerevisiae)
chr1_+_92910805	0.536	ENSMUST00000179711.1	Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1
chr11_-_100441006	0.532	ENSMUST00000092689.2	Nt5c3b	5'-nucleotidase, cytosolic IIIB
chr11_-_100441058	0.526	ENSMUST00000107399.2 ENSMUST00000092688.5	Nt5c3b	5'-nucleotidase, cytosolic IIIB
chr11_-_118355496	0.522	ENSMUST00000017610.3	Timp2	tissue inhibitor of metalloproteinase 2
chr11_+_48800357	0.482	ENSMUST00000020640.7	Gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr9_+_123021315	0.473	ENSMUST00000084733.5	Tmem42	transmembrane protein 42
chr10_+_90829538	0.463	ENSMUST00000179694.2	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B
chr11_+_49247462	0.454	ENSMUST00000109194.1	Mgat1	mannoside acetylglucosaminyltransferase 1
chr18_+_24709436	0.438	ENSMUST00000037097.7	Fhod3	formin homology 2 domain containing 3
chr2_-_131175201	0.429	ENSMUST00000110218.2	Spef1	sperm flagellar 1
chr1_+_36691487	0.419	ENSMUST00000081180.4	Cox5b	cytochrome c oxidase subunit Vb
chr11_+_120633719	0.407	ENSMUST00000181502.1	Gm17586	predicted gene, 17586
chr9_-_112187766	0.402	ENSMUST00000111872.2 ENSMUST00000164754.2	Arpp21	cyclic AMP-regulated phosphoprotein, 21
chr11_-_100440928	0.394	ENSMUST00000107397.1	Nt5c3b	5'-nucleotidase, cytosolic IIIB
chr11_+_78465697	0.391	ENSMUST00000001126.3	Slc46a1	solute carrier family 46, member 1
chrX_+_101383726	0.391	ENSMUST00000119190.1	Gjb1	gap junction protein, beta 1
chr14_+_75845093	0.365	ENSMUST00000110894.2	Tpt1	tumor protein, translationally-controlled 1
chr10_+_88201158	0.359	ENSMUST00000171151.2	Ccdc53	coiled-coil domain containing 53
chr11_+_120762792	0.352	ENSMUST00000105046.2	Hmga1-rs1	high mobility group AT-hook I, related sequence 1
chr11_-_102185239	0.328	ENSMUST00000021297.5	Lsm12	LSM12 homolog (S. cerevisiae)
chr2_+_164948219	0.302	ENSMUST00000017881.2	Mmp9	matrix metallopeptidase 9
chr1_+_92910758	0.301	ENSMUST00000027487.8	Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1
chr11_+_86484647	0.299	ENSMUST00000020827.6	Rnft1	ring finger protein, transmembrane 1
chr10_+_60346851	0.281	ENSMUST00000020301.7 ENSMUST00000105460.1 ENSMUST00000170507.1	4632428N05Rik	RIKEN cDNA 4632428N05 gene
chrX_-_164076482	0.265	ENSMUST00000134272.1	Siah1b	seven in absentia 1B
chr8_+_94857450	0.243	ENSMUST00000109521.3	Polr2c	polymerase (RNA) II (DNA directed) polypeptide C
chr19_+_9982694	0.242	ENSMUST00000025563.6	Fth1	ferritin heavy chain 1
chr11_+_82911253	0.210	ENSMUST00000164945.1 ENSMUST00000018989.7	Unc45b	unc-45 homolog B (C. elegans)
chr5_+_149439706	0.203	ENSMUST00000031667.4	Tex26	testis expressed 26
chr2_-_175131864	0.160	ENSMUST00000108929.2	Gm14399	predicted gene 14399
chr5_+_143403819	0.150	ENSMUST00000110731.2	Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr2_-_91950386	0.142	ENSMUST00000111303.1	Dgkz	diacylglycerol kinase zeta
chr11_-_103344651	0.127	ENSMUST00000041385.7	Arhgap27	Rho GTPase activating protein 27
chr9_-_108305941	0.116	ENSMUST00000044725.7	Tcta	T cell leukemia translocation altered gene
chr7_-_79842287	0.101	ENSMUST00000049004.6	Anpep	alanyl (membrane) aminopeptidase
chr4_+_115088708	0.094	ENSMUST00000171877.1 ENSMUST00000177647.1 ENSMUST00000106548.2 ENSMUST00000030488.2	Pdzk1ip1	PDZK1 interacting protein 1
chr17_-_28517509	0.093	ENSMUST00000114792.1 ENSMUST00000177939.1	Fkbp5	FK506 binding protein 5
chr8_-_13890233	0.083	ENSMUST00000033839.7	Coprs	coordinator of PRMT5, differentiation stimulator
chr14_+_53324632	0.066	ENSMUST00000178100.1	Trav7n-6	T cell receptor alpha variable 7N-6
chr1_-_88008520	0.053	ENSMUST00000040783.4	Usp40	ubiquitin specific peptidase 40
chr4_+_155839675	0.052	ENSMUST00000141883.1	Mxra8	matrix-remodelling associated 8
chr18_+_34331132	0.031	ENSMUST00000072576.3 ENSMUST00000119329.1	Srp19	signal recognition particle 19
chr14_-_55944536	0.027	ENSMUST00000022834.6	Cma1	chymase 1, mast cell
chr2_-_30415302	0.020	ENSMUST00000132981.2 ENSMUST00000129494.1	Crat	carnitine acetyltransferase
chr15_-_79774408	0.020	ENSMUST00000023055.6	Dnal4	dynein, axonemal, light chain 4
chr2_-_118703963	0.011	ENSMUST00000104937.1	Ankrd63	ankyrin repeat domain 63
chr2_+_25500750	0.007	ENSMUST00000015239.3	Fbxw5	F-box and WD-40 domain protein 5

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	6.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.9	8.6	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8	10.0	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.4	1.7	GO:0010046	arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046)
0.4	2.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.4	1.6	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.3	1.3	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3	0.6	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.2	0.7	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.2	0.7	GO:0001550	ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2	0.8	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2	0.9	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1	1.2	GO:0006004	fucose metabolic process(GO:0006004)
0.1	1.2	GO:0006228	UTP biosynthetic process(GO:0006228)
0.1	0.4	GO:0015886	heme transport(GO:0015886)
0.1	0.5	GO:0006049	UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1	9.2	GO:0048663	neuron fate commitment(GO:0048663)
0.1	6.3	GO:0051496	positive regulation of stress fiber assembly(GO:0051496)
0.1	2.0	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.1	1.3	GO:0048199	protein localization to pre-autophagosomal structure(GO:0034497) vesicle targeting, to, from or within Golgi(GO:0048199)
0.1	1.5	GO:0030574	collagen catabolic process(GO:0030574)
0.1	0.4	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1	0.5	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1	0.4	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1	1.0	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0	0.9	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	4.1	GO:0007601	visual perception(GO:0007601)
0.0	0.4	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.5	GO:1900383	regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0	0.4	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.8	GO:0035767	endothelial cell chemotaxis(GO:0035767)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	1.0	GO:0034605	cellular response to heat(GO:0034605)
0.0	1.0	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.5	GO:0043171	peptide catabolic process(GO:0043171)
0.0	0.1	GO:0060857	establishment of glial blood-brain barrier(GO:0060857)
0.0	0.2	GO:0097286	iron ion import(GO:0097286)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	10.0	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4	6.1	GO:0005614	interstitial matrix(GO:0005614)
0.1	1.7	GO:0070852	cell body fiber(GO:0070852)
0.1	0.7	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.7	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.1	1.3	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	0.9	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	0.4	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	2.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.4	GO:0045298	tubulin complex(GO:0045298)
0.0	0.8	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.4	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	9.2	GO:0005667	transcription factor complex(GO:0005667)
0.0	1.2	GO:0005882	intermediate filament(GO:0005882)
0.0	1.0	GO:0005581	collagen trimer(GO:0005581)
0.0	0.2	GO:0044754	autolysosome(GO:0044754)
0.0	0.4	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	5.9	GO:0005925	focal adhesion(GO:0005925)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.8	GO:0000786	nucleosome(GO:0000786)
0.0	1.5	GO:0000776	kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	10.0	GO:0042289	MHC class II protein binding(GO:0042289)
1.4	8.6	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
1.0	6.1	GO:0045545	syndecan binding(GO:0045545)
0.8	5.0	GO:0019841	retinol binding(GO:0019841)
0.4	6.3	GO:0017166	vinculin binding(GO:0017166)
0.3	1.2	GO:0042806	fucose binding(GO:0042806)
0.2	0.6	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2	0.9	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2	0.7	GO:0035877	death effector domain binding(GO:0035877)
0.2	0.7	GO:0034511	U3 snoRNA binding(GO:0034511)
0.2	0.9	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1	1.7	GO:0015643	toxic substance binding(GO:0015643)
0.1	0.4	GO:0015232	heme transporter activity(GO:0015232)
0.1	0.5	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1	1.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.1	1.5	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	2.1	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1	0.7	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	1.0	GO:0031418	L-ascorbic acid binding(GO:0031418)
0.1	1.3	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.2	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.5	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.9	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.4	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.4	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	1.6	GO:0019213	deacetylase activity(GO:0019213)
0.0	0.2	GO:0001055	RNA polymerase II activity(GO:0001055)
0.0	0.4	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	1.3	GO:0002039	p53 binding(GO:0002039)
0.0	1.0	GO:0004222	metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	17.2	PID_INTEGRIN1_PATHWAY	Beta1 integrin cell surface interactions
0.2	2.1	PID_THROMBIN_PAR4_PATHWAY	PAR4-mediated thrombin signaling events
0.1	3.5	PID_CDC42_REG_PATHWAY	Regulation of CDC42 activity
0.0	2.5	PID_TNF_PATHWAY	TNF receptor signaling pathway
0.0	0.7	PID_BMP_PATHWAY	BMP receptor signaling
0.0	0.3	PID_SYNDECAN_4_PATHWAY	Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.1	REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	8.6	REACTOME_GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.2	10.0	REACTOME_NCAM1_INTERACTIONS	Genes involved in NCAM1 interactions
0.2	6.3	REACTOME_SMOOTH_MUSCLE_CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.0	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	0.9	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	5.0	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	0.7	REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.6	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	1.2	REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.8	REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.4	REACTOME_GAP_JUNCTION_ASSEMBLY	Genes involved in Gap junction assembly
0.0	1.3	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.7	REACTOME_SIGNALING_BY_BMP	Genes involved in Signaling by BMP
0.0	2.3	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.6	REACTOME_IRON_UPTAKE_AND_TRANSPORT	Genes involved in Iron uptake and transport
0.0	0.2	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.5	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification

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