Motif ID: Rad21_Smc3

Z-value: 0.860

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rad21mm10_v2_chr15_-_51991679_51991760-0.312.1e-02Click!
Smc3mm10_v2_chr19_+_53600377_53600435-0.124.0e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_110168204 6.606 ENSMUST00000003754.6
 Calb2
calbindin 2
chr2_+_157914618 4.776 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr2_-_117342709 3.621 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr7_+_35119285 3.433 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr8_+_87473116 3.240 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr9_-_42944479 3.082 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr5_+_17574268 2.910 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_59964936 2.672 ENSMUST00000062405.7
 Rasd1
RAS, dexamethasone-induced 1
chr6_-_137169710 2.605 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr9_+_71215779 2.443 ENSMUST00000034723.5
 Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr8_+_87472805 2.386 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr6_-_137169678 2.269 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr5_+_147957310 2.223 ENSMUST00000085558.4
ENSMUST00000129092.1
 Mtus2

microtubule associated tumor suppressor candidate 2

chr9_-_58204310 2.154 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr7_+_16891755 2.146 ENSMUST00000078182.4
 Gng8
guanine nucleotide binding protein (G protein), gamma 8
chr3_-_121171678 2.120 ENSMUST00000170781.1
ENSMUST00000039761.5
ENSMUST00000106467.1
ENSMUST00000106466.3
ENSMUST00000164925.2
 Rwdd3




RWD domain containing 3




chr8_+_87472838 2.054 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr4_-_45530330 1.885 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr2_+_167538192 1.858 ENSMUST00000052631.7
 Snai1
snail homolog 1 (Drosophila)
chr7_+_25686994 1.825 ENSMUST00000002678.9
 Tgfb1
transforming growth factor, beta 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
1.2 3.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0 3.7 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.4 3.6 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 3.5 GO:0030308 negative regulation of cell growth(GO:0030308)
0.5 2.9 GO:0003350 pulmonary myocardium development(GO:0003350)
0.7 2.7 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 2.7 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.8 2.4 GO:0035799 ureter maturation(GO:0035799)
0.0 2.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.7 2.1 GO:1902071 positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.4 2.1 GO:0019236 response to pheromone(GO:0019236)
0.3 2.1 GO:0032439 endosome localization(GO:0032439)
0.4 2.0 GO:0046684 response to pyrethroid(GO:0046684)
0.6 1.9 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.2 1.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.6 1.7 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.4 1.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 1.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 1.7 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0005921 gap junction(GO:0005921)
0.0 4.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.2 3.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.5 3.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 2.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 2.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.7 GO:0045179 apical cortex(GO:0045179)
0.2 1.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.7 GO:0097225 sperm midpiece(GO:0097225)
0.3 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.6 GO:0043196 varicosity(GO:0043196)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.0 GO:0005883 neurofilament(GO:0005883)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 3.7 GO:0004454 ketohexokinase activity(GO:0004454)
0.2 3.4 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 3.0 GO:0051117 ATPase binding(GO:0051117)
0.1 2.9 GO:0044390 ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 2.6 GO:0038191 neuropilin binding(GO:0038191)
0.5 2.4 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 2.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.5 1.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 1.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.6 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 3.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.1 PID_P73PATHWAY p73 transcription factor network
0.1 3.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 3.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 2.1 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 2.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 0.9 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events