Motif ID: Rbpj

Z-value: 1.013


Transcription factors associated with Rbpj:

Gene SymbolEntrez IDGene Name
Rbpj ENSMUSG00000039191.6 Rbpj

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rbpjmm10_v2_chr5_+_53590453_535905740.508.8e-05Click!


Activity profile for motif Rbpj.

activity profile for motif Rbpj


Sorted Z-values histogram for motif Rbpj

Sorted Z-values for motif Rbpj



Network of associatons between targets according to the STRING database.



First level regulatory network of Rbpj

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_154960915 19.231 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_78324200 13.598 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr10_-_30842765 9.625 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr11_-_102579461 8.680 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr2_+_105668888 8.053 ENSMUST00000111086.4
ENSMUST00000111087.3
Pax6

paired box gene 6

chr11_+_101627942 7.828 ENSMUST00000010506.3
Rdm1
RAD52 motif 1
chr7_+_122159422 7.598 ENSMUST00000033154.6
Plk1
polo-like kinase 1
chr2_+_105668935 7.355 ENSMUST00000142772.1
Pax6
paired box gene 6
chr4_+_156203292 7.009 ENSMUST00000105140.2
AW011738
expressed sequence AW011738
chr9_+_123478693 6.857 ENSMUST00000026269.2
Limd1
LIM domains containing 1
chr15_-_86033777 6.029 ENSMUST00000016172.7
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr2_+_37776229 5.926 ENSMUST00000050372.7
Crb2
crumbs homolog 2 (Drosophila)
chr2_+_59612034 5.805 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chrX_+_139684980 5.671 ENSMUST00000096313.3
Tbc1d8b
TBC1 domain family, member 8B
chr6_-_5298455 5.226 ENSMUST00000057792.8
Pon2
paraoxonase 2
chr18_+_34625009 5.119 ENSMUST00000166044.1
Kif20a
kinesin family member 20A
chr7_+_45216671 4.875 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr4_-_11007635 4.597 ENSMUST00000054776.3
Plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr4_+_8690399 4.278 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr18_+_34624621 3.794 ENSMUST00000167161.1
Kif20a
kinesin family member 20A
chr7_-_105752193 3.701 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr19_+_53140430 3.539 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr5_+_33658550 3.263 ENSMUST00000152847.1
Tacc3
transforming, acidic coiled-coil containing protein 3
chr1_-_191575534 3.194 ENSMUST00000027933.5
Dtl
denticleless homolog (Drosophila)
chr7_+_44748584 3.108 ENSMUST00000171821.1
Vrk3
vaccinia related kinase 3
chr7_+_44748640 3.007 ENSMUST00000165957.1
ENSMUST00000144515.2
Vrk3

vaccinia related kinase 3

chr7_+_44748413 3.007 ENSMUST00000002275.8
Vrk3
vaccinia related kinase 3
chr9_-_26806384 2.987 ENSMUST00000162702.1
ENSMUST00000040398.7
ENSMUST00000066560.6
Glb1l2


galactosidase, beta 1-like 2


chr5_-_77115145 2.912 ENSMUST00000081964.5
Hopx
HOP homeobox
chrX_+_99136119 2.555 ENSMUST00000052839.6
Efnb1
ephrin B1
chr6_+_29694204 2.519 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr5_+_136919137 2.376 ENSMUST00000181045.1
4933404O12Rik
RIKEN cDNA 4933404O12 gene
chr12_-_80260091 2.301 ENSMUST00000167327.1
Actn1
actinin, alpha 1
chr7_+_16842896 2.299 ENSMUST00000168093.2
Prkd2
protein kinase D2
chr6_+_48593883 2.126 ENSMUST00000154010.1
ENSMUST00000163452.1
ENSMUST00000118229.1
ENSMUST00000009420.8
Repin1



replication initiator 1



chr2_-_54085542 1.963 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_26140468 1.946 ENSMUST00000133808.1
C330006A16Rik
RIKEN cDNA C330006A16 gene
chr5_+_115327125 1.911 ENSMUST00000031513.7
Srsf9
serine/arginine-rich splicing factor 9
chr4_+_107830958 1.882 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr9_-_55512156 1.874 ENSMUST00000034866.8
Etfa
electron transferring flavoprotein, alpha polypeptide
chr2_-_69586021 1.754 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr12_-_80260356 1.745 ENSMUST00000021554.8
Actn1
actinin, alpha 1
chr15_-_81858317 1.608 ENSMUST00000050467.7
Tob2
transducer of ERBB2, 2
chr7_+_126781483 1.602 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr2_+_92184106 1.553 ENSMUST00000111294.1
ENSMUST00000111293.2
ENSMUST00000162146.1
ENSMUST00000111292.1
ENSMUST00000162497.1
Phf21a




PHD finger protein 21A




chr5_-_88675613 1.536 ENSMUST00000113234.1
ENSMUST00000153565.1
Grsf1

G-rich RNA sequence binding factor 1

chr7_+_29983948 1.517 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr19_-_10577362 1.512 ENSMUST00000025568.2
Tmem138
transmembrane protein 138
chr15_-_75894474 1.507 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chrX_+_42149288 1.451 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr7_+_45639964 1.371 ENSMUST00000148532.1
Mamstr
MEF2 activating motif and SAP domain containing transcriptional regulator
chr2_+_133552159 1.331 ENSMUST00000028836.6
Bmp2
bone morphogenetic protein 2
chr17_+_35121455 1.242 ENSMUST00000173380.1
ENSMUST00000173043.3
ENSMUST00000165306.2
Gpank1


G patch domain and ankyrin repeats 1


chr13_+_12395362 1.192 ENSMUST00000059270.8
Heatr1
HEAT repeat containing 1
chr15_+_83563571 1.186 ENSMUST00000047419.6
Tspo
translocator protein
chr10_+_29313227 1.162 ENSMUST00000161605.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr9_-_97018823 1.162 ENSMUST00000055433.4
Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr11_+_63133068 1.161 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr7_-_44670820 1.159 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr3_-_89270489 1.145 ENSMUST00000107460.1
ENSMUST00000029565.4
ENSMUST00000130230.1
Slc50a1


solute carrier family 50 (sugar transporter), member 1


chr2_+_164746028 1.090 ENSMUST00000109327.3
Dnttip1
deoxynucleotidyltransferase, terminal, interacting protein 1
chrX_-_160138375 1.039 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr5_+_138187485 1.023 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr7_-_24208093 1.019 ENSMUST00000086006.5
Zfp111
zinc finger protein 111
chr8_-_69974367 0.993 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chrX_+_58030622 0.987 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr19_+_46056539 0.979 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr12_+_82170016 0.865 ENSMUST00000166429.1
Sipa1l1
signal-induced proliferation-associated 1 like 1
chr9_-_13446753 0.862 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr2_+_164745979 0.837 ENSMUST00000017443.7
ENSMUST00000109326.3
Dnttip1

deoxynucleotidyltransferase, terminal, interacting protein 1

chr2_+_154548888 0.834 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr7_+_127777376 0.826 ENSMUST00000126761.1
ENSMUST00000047157.6
Setd1a

SET domain containing 1A

chr5_-_138172383 0.780 ENSMUST00000000505.9
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_-_24577467 0.780 ENSMUST00000030795.8
Abcf2
ATP-binding cassette, sub-family F (GCN20), member 2
chr1_+_97770158 0.740 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chr13_-_67360509 0.734 ENSMUST00000081582.6
ENSMUST00000185002.1
Zfp953
ZFP953
zinc finger protein 953
Protein Zfp953
chr15_-_55072139 0.718 ENSMUST00000041733.7
Taf2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_+_35559460 0.713 ENSMUST00000034615.3
ENSMUST00000121246.1
Pus3

pseudouridine synthase 3

chr10_-_81266906 0.705 ENSMUST00000046114.4
Mrpl54
mitochondrial ribosomal protein L54
chr4_-_149166686 0.688 ENSMUST00000084124.6
Pgd
phosphogluconate dehydrogenase
chr6_+_50110186 0.677 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr7_-_44748306 0.645 ENSMUST00000118162.1
ENSMUST00000140599.2
ENSMUST00000120798.1
Zfp473


zinc finger protein 473


chr14_-_56571830 0.640 ENSMUST00000065302.7
Cenpj
centromere protein J
chr5_-_88675190 0.638 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr1_+_150393250 0.633 ENSMUST00000119161.2
Tpr
translocated promoter region
chr9_-_114640175 0.632 ENSMUST00000070117.6
Cnot10
CCR4-NOT transcription complex, subunit 10
chr3_-_103809278 0.603 ENSMUST00000063502.6
ENSMUST00000106832.1
ENSMUST00000106834.1
ENSMUST00000029435.8
Dclre1b



DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)



chrX_+_7579666 0.586 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr2_-_120609319 0.578 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr2_-_120609500 0.568 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr10_-_62726086 0.548 ENSMUST00000133371.1
Stox1
storkhead box 1
chr2_-_120609283 0.527 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr11_-_50887443 0.504 ENSMUST00000050595.6
ENSMUST00000163301.1
ENSMUST00000109131.1
ENSMUST00000125749.1
Zfp454



zinc finger protein 454



chr6_+_21949571 0.504 ENSMUST00000031680.3
ENSMUST00000115389.1
ENSMUST00000151473.1
Ing3


inhibitor of growth family, member 3


chr8_-_111743799 0.475 ENSMUST00000166232.2
Bcar1
breast cancer anti-estrogen resistance 1
chr2_+_120609383 0.466 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr12_-_73047179 0.454 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr3_+_146220955 0.452 ENSMUST00000039164.2
Lpar3
lysophosphatidic acid receptor 3
chr9_+_106821874 0.445 ENSMUST00000159645.1
Vprbp
Vpr (HIV-1) binding protein
chr7_+_5020561 0.435 ENSMUST00000085427.3
Zfp865
zinc finger protein 865
chrX_-_134600976 0.431 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr17_+_34205100 0.420 ENSMUST00000131105.1
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_+_119547697 0.380 ENSMUST00000014221.6
ENSMUST00000119172.1
Chp1

calcineurin-like EF hand protein 1

chr16_+_22009471 0.378 ENSMUST00000023561.7
Senp2
SUMO/sentrin specific peptidase 2
chr2_+_164403194 0.372 ENSMUST00000017151.1
Rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr5_+_3543812 0.370 ENSMUST00000115527.3
Fam133b
family with sequence similarity 133, member B
chr5_+_135994796 0.362 ENSMUST00000111142.2
ENSMUST00000111145.3
ENSMUST00000111144.1
ENSMUST00000005072.3
ENSMUST00000130345.1
Dtx2




deltex 2 homolog (Drosophila)




chr11_+_98937669 0.359 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara

retinoic acid receptor, alpha

chr7_+_5020376 0.359 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chr4_-_126202757 0.329 ENSMUST00000080919.5
Thrap3
thyroid hormone receptor associated protein 3
chr12_+_33315393 0.329 ENSMUST00000154742.1
Atxn7l1
ataxin 7-like 1
chr3_+_7612702 0.322 ENSMUST00000181286.1
Gm16685
predicted gene, 16685
chr4_-_126202583 0.313 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
Thrap3


thyroid hormone receptor associated protein 3


chr14_-_66124482 0.307 ENSMUST00000070515.1
Ephx2
epoxide hydrolase 2, cytoplasmic
chr5_+_148959263 0.296 ENSMUST00000135240.1
Gm15409
predicted gene 15409
chr4_-_156197479 0.290 ENSMUST00000075787.6
ENSMUST00000180572.1
Agrn

agrin

chr11_+_78178651 0.285 ENSMUST00000092880.7
ENSMUST00000127587.1
ENSMUST00000108338.1
Tlcd1


TLC domain containing 1


chr2_+_120404757 0.269 ENSMUST00000135074.1
Ganc
glucosidase, alpha; neutral C
chr1_+_87327044 0.252 ENSMUST00000173173.1
Gigyf2
GRB10 interacting GYF protein 2
chr19_+_7297658 0.244 ENSMUST00000170286.1
Gm17227
predicted gene 17227
chr14_+_75131499 0.239 ENSMUST00000125833.1
ENSMUST00000124499.1
Lcp1

lymphocyte cytosolic protein 1

chr11_+_109485606 0.230 ENSMUST00000106697.1
Arsg
arylsulfatase G
chr7_-_100121512 0.207 ENSMUST00000032969.7
Pold3
polymerase (DNA-directed), delta 3, accessory subunit
chr19_+_56397100 0.198 ENSMUST00000026062.9
Casp7
caspase 7
chr7_+_127967457 0.195 ENSMUST00000106251.3
ENSMUST00000077609.5
ENSMUST00000121616.2
Fus


fused in sarcoma


chr10_-_93889609 0.193 ENSMUST00000180375.1
Metap2
methionine aminopeptidase 2
chr2_-_92370968 0.171 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr4_-_107178282 0.164 ENSMUST00000058585.7
Tceanc2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr11_-_62457772 0.163 ENSMUST00000127471.2
Ncor1
nuclear receptor co-repressor 1
chr6_+_55203381 0.154 ENSMUST00000053094.7
Fam188b
family with sequence similarity 188, member B
chr11_-_113684155 0.144 ENSMUST00000120194.1
Fam104a
family with sequence similarity 104, member A
chr17_-_35121213 0.141 ENSMUST00000025246.6
Csnk2b
casein kinase 2, beta polypeptide
chr7_+_5015466 0.136 ENSMUST00000086349.3
Zfp524
zinc finger protein 524
chr1_+_74153981 0.123 ENSMUST00000027372.7
ENSMUST00000106899.2
Cxcr2

chemokine (C-X-C motif) receptor 2

chr12_+_8973892 0.110 ENSMUST00000085745.6
ENSMUST00000111113.2
Wdr35

WD repeat domain 35

chr16_+_44943737 0.099 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr12_-_36382181 0.094 ENSMUST00000171007.1
D630036H23Rik
RIKEN cDNA D630036H23 gene
chrX_+_100494291 0.077 ENSMUST00000033570.5
Igbp1
immunoglobulin (CD79A) binding protein 1
chr13_+_23684192 0.075 ENSMUST00000018246.4
Hist1h2bc
histone cluster 1, H2bc
chr8_+_67494843 0.058 ENSMUST00000093470.5
ENSMUST00000163856.1
Nat2

N-acetyltransferase 2 (arylamine N-acetyltransferase)

chr2_+_167062934 0.056 ENSMUST00000125674.1
1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr11_-_62457289 0.051 ENSMUST00000069456.4
ENSMUST00000018645.6
Ncor1

nuclear receptor co-repressor 1

chr3_+_131564768 0.051 ENSMUST00000029666.9
Papss1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr9_+_44334685 0.050 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr12_-_4477138 0.040 ENSMUST00000085814.3
Ncoa1
nuclear receptor coactivator 1
chr19_+_8967031 0.037 ENSMUST00000052248.7
Eef1g
eukaryotic translation elongation factor 1 gamma
chr12_-_88286055 0.026 ENSMUST00000179741.1
Gm7104
predicted gene 7104
chr17_+_36869567 0.025 ENSMUST00000060524.9
Trim10
tripartite motif-containing 10
chr5_+_130257029 0.013 ENSMUST00000100662.3
ENSMUST00000040213.6
Tyw1

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

chr7_+_29768552 0.011 ENSMUST00000032802.4
Zfp84
zinc finger protein 84

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
3.2 9.6 GO:0003195 tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
3.1 15.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
2.1 4.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
2.0 6.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.9 7.6 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038)
1.9 5.6 GO:0014028 notochord formation(GO:0014028)
1.4 13.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 6.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.5 9.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.5 1.5 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.5 8.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.5 2.9 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.4 1.3 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 2.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 0.6 GO:0061511 centriole elongation(GO:0061511)
0.3 0.3 GO:1900673 olefin metabolic process(GO:1900673)
0.2 1.0 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.2 0.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 3.2 GO:0019985 translesion synthesis(GO:0019985)
0.2 1.2 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.2 3.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 0.7 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 3.3 GO:0051639 actin filament network formation(GO:0051639)
0.2 4.9 GO:0030903 notochord development(GO:0030903)
0.2 0.6 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.2 1.9 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 5.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.2 0.6 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.2 1.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 1.2 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 0.6 GO:0032829 positive regulation of T cell anergy(GO:0002669) negative regulation of T cell cytokine production(GO:0002725) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 1.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 0.5 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 1.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.4 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.1 0.4 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 2.6 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.7 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 3.7 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.5 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.1 1.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 1.8 GO:0045056 transcytosis(GO:0045056)
0.1 0.4 GO:0032875 regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023)
0.1 1.6 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 2.1 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.1 1.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.4 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 1.6 GO:0001967 suckling behavior(GO:0001967)
0.1 0.6 GO:0015074 DNA integration(GO:0015074)
0.1 1.6 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 5.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 0.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 1.9 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.2 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.1 1.4 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 1.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 5.2 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 3.3 GO:0042493 response to drug(GO:0042493)
0.0 1.9 GO:0008033 tRNA processing(GO:0008033)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.6 4.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.0 4.0 GO:0032127 dense core granule membrane(GO:0032127)
0.5 6.9 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.5 9.8 GO:0016580 Sin3 complex(GO:0016580)
0.5 1.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.5 3.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 2.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.2 GO:0097513 myosin II filament(GO:0097513)
0.1 1.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 8.9 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 4.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 2.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 3.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 15.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 19.8 GO:0030424 axon(GO:0030424)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 6.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 15.1 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 5.9 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.2 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 1.5 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0035939 microsatellite binding(GO:0035939)
2.3 13.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.3 5.2 GO:0004064 arylesterase activity(GO:0004064)
1.3 7.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.2 5.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.0 15.4 GO:0003680 AT DNA binding(GO:0003680)
0.9 3.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.6 3.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.6 1.8 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.5 1.9 GO:0038025 reelin receptor activity(GO:0038025)
0.3 4.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 0.7 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 4.0 GO:0017166 vinculin binding(GO:0017166)
0.2 0.7 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 0.7 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.2 0.4 GO:0015925 galactosidase activity(GO:0015925)
0.2 1.0 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 1.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.2 0.8 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.4 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 4.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 8.9 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 19.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.3 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.3 GO:0032450 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.1 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 9.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 3.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 4.4 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 1.2 GO:0030515 snoRNA binding(GO:0030515)
0.0 7.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.1 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.0 GO:0042562 hormone binding(GO:0042562)
0.0 6.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 4.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 2.1 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 35.1 PID_CDC42_PATHWAY CDC42 signaling events
0.3 18.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 9.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 15.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 7.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 29.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 8.9 REACTOME_KINESINS Genes involved in Kinesins
0.3 13.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 4.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 1.9 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 5.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.9 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation