Motif ID: Rbpj

Z-value: 1.013


Transcription factors associated with Rbpj:

Gene SymbolEntrez IDGene Name
Rbpj ENSMUSG00000039191.6 Rbpj

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rbpjmm10_v2_chr5_+_53590453_535905740.508.8e-05Click!


Activity profile for motif Rbpj.

activity profile for motif Rbpj


Sorted Z-values histogram for motif Rbpj

Sorted Z-values for motif Rbpj



Network of associatons between targets according to the STRING database.



First level regulatory network of Rbpj

PNG image of the network

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Top targets:


Showing 1 to 20 of 150 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 19.231 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_78324200 13.598 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr10_-_30842765 9.625 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr11_-_102579461 8.680 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_+_105668888 8.053 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr11_+_101627942 7.828 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr7_+_122159422 7.598 ENSMUST00000033154.6
 Plk1
polo-like kinase 1
chr2_+_105668935 7.355 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr4_+_156203292 7.009 ENSMUST00000105140.2
 AW011738
expressed sequence AW011738
chr9_+_123478693 6.857 ENSMUST00000026269.2
 Limd1
LIM domains containing 1
chr15_-_86033777 6.029 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr2_+_37776229 5.926 ENSMUST00000050372.7
 Crb2
crumbs homolog 2 (Drosophila)
chr2_+_59612034 5.805 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chrX_+_139684980 5.671 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr6_-_5298455 5.226 ENSMUST00000057792.8
 Pon2
paraoxonase 2
chr18_+_34625009 5.119 ENSMUST00000166044.1
 Kif20a
kinesin family member 20A
chr7_+_45216671 4.875 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr4_-_11007635 4.597 ENSMUST00000054776.3
 Plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr4_+_8690399 4.278 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr18_+_34624621 3.794 ENSMUST00000167161.1
 Kif20a
kinesin family member 20A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 19.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
3.1 15.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.4 13.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
3.2 9.6 GO:0003195 tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.5 9.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.5 8.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.9 7.6 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038)
1.0 6.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
2.0 6.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 5.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 5.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.9 5.6 GO:0014028 notochord formation(GO:0014028)
0.0 5.2 GO:0009636 response to toxic substance(GO:0009636)
0.2 4.9 GO:0030903 notochord development(GO:0030903)
2.1 4.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 3.7 GO:0043171 peptide catabolic process(GO:0043171)
0.2 3.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 3.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 3.3 GO:0042493 response to drug(GO:0042493)
0.2 3.2 GO:0019985 translesion synthesis(GO:0019985)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.8 GO:0030424 axon(GO:0030424)
0.0 15.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 15.1 GO:0005730 nucleolus(GO:0005730)
0.5 9.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 8.9 GO:0005871 kinesin complex(GO:0005871)
1.9 7.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.5 6.9 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 6.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.9 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.6 4.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 4.5 GO:0000118 histone deacetylase complex(GO:0000118)
1.0 4.0 GO:0032127 dense core granule membrane(GO:0032127)
0.0 3.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.5 3.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 2.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 1.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 1.2 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 15.4 GO:0003680 AT DNA binding(GO:0003680)
2.3 13.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.2 9.6 GO:0035939 microsatellite binding(GO:0035939)
0.0 9.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 8.9 GO:0003777 microtubule motor activity(GO:0003777)
1.3 7.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 7.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 6.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.2 5.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.3 5.2 GO:0004064 arylesterase activity(GO:0004064)
0.3 4.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 4.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.4 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 4.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 4.0 GO:0017166 vinculin binding(GO:0017166)
0.9 3.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 3.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.6 3.0 GO:0004565 beta-galactosidase activity(GO:0004565)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.1 PID_CDC42_PATHWAY CDC42 signaling events
0.3 18.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 9.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 29.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.1 15.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 13.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 8.9 REACTOME_KINESINS Genes involved in Kinesins
0.4 7.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 5.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 4.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.9 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.9 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 1.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA