Motif ID: Rela_Rel_Nfkb1

Z-value: 1.723

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135608221_1356082900.728.3e-10Click!
Relamm10_v2_chr19_+_5637475_56374860.431.1e-03Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_165234689 27.750 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr1_+_74791516 23.541 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr8_-_61902669 19.417 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr7_-_25788635 16.940 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr17_-_35000848 12.727 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr6_+_4755327 12.651 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr1_+_64532790 12.635 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr6_-_48840988 12.349 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 12.230 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_+_48841476 12.192 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_-_48841373 11.965 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr6_+_48841633 11.738 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr14_-_70642268 11.351 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr5_+_92925400 10.597 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr12_+_79029150 10.059 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr7_-_102250086 10.033 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr17_-_35000746 9.923 ENSMUST00000163360.1
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr18_+_4994600 8.766 ENSMUST00000140448.1
 Svil
supervillin
chr19_+_46304709 8.727 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr2_-_151973387 8.725 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.0 63.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
2.0 23.5 GO:0048733 sebaceous gland development(GO:0048733)
1.0 21.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.8 21.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.3 20.9 GO:0003334 keratinocyte development(GO:0003334)
5.6 16.9 GO:0097350 neutrophil clearance(GO:0097350)
1.5 14.8 GO:0008063 Toll signaling pathway(GO:0008063)
1.4 14.3 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
1.9 13.6 GO:0098535 de novo centriole assembly(GO:0098535)
1.0 13.6 GO:0002467 germinal center formation(GO:0002467)
0.3 13.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
4.2 12.6 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.2 12.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
2.0 12.2 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.1 12.1 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
3.6 10.9 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.6 10.1 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.4 10.0 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.7 9.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.1 8.8 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 23.0 GO:0002102 podosome(GO:0002102)
0.2 22.8 GO:0031225 anchored component of membrane(GO:0031225)
2.7 18.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 17.3 GO:0000922 spindle pole(GO:0000922)
0.0 14.6 GO:0005925 focal adhesion(GO:0005925)
0.1 13.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 12.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 12.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 12.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 11.4 GO:0043296 apical junction complex(GO:0043296)
1.9 11.2 GO:0098536 deuterosome(GO:0098536)
2.2 10.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 10.5 GO:0043235 receptor complex(GO:0043235)
0.2 10.0 GO:0005882 intermediate filament(GO:0005882)
0.4 9.8 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.1 9.5 GO:0030496 midbody(GO:0030496)
0.6 9.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 8.9 GO:0000118 histone deacetylase complex(GO:0000118)
1.6 8.2 GO:0031523 Myb complex(GO:0031523)
0.2 7.6 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 30.5 GO:0005509 calcium ion binding(GO:0005509)
0.6 24.7 GO:0005109 frizzled binding(GO:0005109)
0.2 21.4 GO:0005178 integrin binding(GO:0005178)
2.4 21.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 19.5 GO:0051015 actin filament binding(GO:0051015)
0.4 18.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.5 16.9 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 14.8 GO:0031996 thioesterase binding(GO:0031996)
0.0 13.3 GO:0003723 RNA binding(GO:0003723)
4.2 12.6 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.6 12.3 GO:0070410 co-SMAD binding(GO:0070410)
3.8 11.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 10.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 9.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 8.8 GO:0019003 GDP binding(GO:0019003)
2.0 8.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.7 7.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
1.8 7.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 7.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 48.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 26.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.4 23.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 20.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 16.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 15.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 13.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 12.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 12.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.5 11.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 10.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.2 9.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 8.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 8.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 8.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 7.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 7.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.8 PID_CDC42_PATHWAY CDC42 signaling events
0.3 6.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.2 5.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 17.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.9 16.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.1 15.1 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.6 14.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 13.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.7 12.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 12.1 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
1.3 11.4 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.3 10.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 9.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 8.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 8.0 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
1.1 7.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.3 7.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 6.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.5 6.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 6.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 5.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation