Motif ID: Rest

Z-value: 2.687


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.265.4e-02Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_42255704 62.009 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 48.517 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr2_-_25319095 30.420 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chrX_-_73869804 27.218 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr5_-_121009510 26.367 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr9_+_40269430 26.363 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr18_-_31447383 25.991 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr7_-_27396542 24.644 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr9_+_40269273 24.313 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 23.140 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr1_+_34579693 22.705 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr11_-_35798884 22.445 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr2_-_27142429 22.040 ENSMUST00000151224.2
 Fam163b
family with sequence similarity 163, member B
chr17_+_28575718 21.723 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr2_-_25319187 21.461 ENSMUST00000114312.1
 Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr17_-_91092715 20.838 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr11_+_74619594 20.448 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr13_-_54749627 19.079 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr9_+_59578192 18.704 ENSMUST00000118549.1
ENSMUST00000034840.3
 Celf6

CUGBP, Elav-like family member 6

chr4_+_101550411 17.833 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.2 73.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
5.6 62.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
17.3 51.9 GO:1900673 olefin metabolic process(GO:1900673)
1.9 48.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
4.3 38.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
2.1 30.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
1.1 28.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.7 27.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.8 26.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 26.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
4.1 24.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 22.5 GO:0031175 neuron projection development(GO:0031175)
4.5 22.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
5.2 20.8 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.9 18.7 GO:0071625 vocalization behavior(GO:0071625)
0.1 17.2 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 17.0 GO:0007286 spermatid development(GO:0007286)
8.3 16.7 GO:0021586 pons maturation(GO:0021586)
1.4 16.7 GO:0043084 penile erection(GO:0043084)
1.2 16.7 GO:0097091 synaptic vesicle clustering(GO:0097091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 73.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
5.2 62.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 60.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 52.7 GO:0005886 plasma membrane(GO:0005886)
13.0 51.9 GO:0044307 dendritic branch(GO:0044307)
1.0 44.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.3 28.0 GO:0044294 dendritic growth cone(GO:0044294)
2.0 26.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
1.7 26.0 GO:0097449 astrocyte projection(GO:0097449)
0.0 25.4 GO:0070062 extracellular exosome(GO:0070062)
0.7 24.9 GO:0048786 presynaptic active zone(GO:0048786)
4.1 24.6 GO:0008091 spectrin(GO:0008091)
3.2 22.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.2 21.7 GO:0032426 stereocilium tip(GO:0032426)
2.3 20.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 20.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 19.4 GO:0060077 inhibitory synapse(GO:0060077)
5.6 16.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 16.7 GO:0030667 secretory granule membrane(GO:0030667)
0.4 16.3 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.5 73.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
2.1 62.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
8.6 51.9 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.6 48.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 32.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.7 28.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
4.5 27.2 GO:0033691 sialic acid binding(GO:0033691)
2.6 26.4 GO:0042301 phosphate ion binding(GO:0042301)
6.5 26.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 25.3 GO:0015485 cholesterol binding(GO:0015485)
0.4 24.6 GO:0030507 spectrin binding(GO:0030507)
0.4 22.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
1.4 22.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
1.7 20.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 20.0 GO:0000149 SNARE binding(GO:0000149)
0.2 18.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 17.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 16.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
4.2 16.6 GO:0004966 galanin receptor activity(GO:0004966)
0.1 16.0 GO:0005261 cation channel activity(GO:0005261)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 73.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.6 27.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.4 16.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 15.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 12.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 11.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 125.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.5 67.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.9 28.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
1.1 16.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.8 16.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 16.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 12.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 12.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 12.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.8 11.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
1.5 9.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 6.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 2.8 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 2.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 2.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors