Motif ID: Rest

Z-value: 2.687


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.265.4e-02Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_42255704 62.009 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 48.517 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr2_-_25319095 30.420 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chrX_-_73869804 27.218 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr5_-_121009510 26.367 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr9_+_40269430 26.363 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr18_-_31447383 25.991 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr7_-_27396542 24.644 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr9_+_40269273 24.313 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 23.140 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr1_+_34579693 22.705 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr11_-_35798884 22.445 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr2_-_27142429 22.040 ENSMUST00000151224.2
 Fam163b
family with sequence similarity 163, member B
chr17_+_28575718 21.723 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr2_-_25319187 21.461 ENSMUST00000114312.1
 Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr17_-_91092715 20.838 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr11_+_74619594 20.448 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr13_-_54749627 19.079 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr9_+_59578192 18.704 ENSMUST00000118549.1
ENSMUST00000034840.3
 Celf6

CUGBP, Elav-like family member 6

chr4_+_101550411 17.833 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr12_-_112511136 17.435 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr11_-_3774706 17.037 ENSMUST00000155197.1
 Osbp2
oxysterol binding protein 2
chr11_+_80477015 16.696 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chrX_-_20920911 16.670 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr5_+_137030275 16.655 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr15_-_11037968 16.613 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr13_-_54749849 16.107 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr19_+_22139028 16.027 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr3_-_80802789 15.829 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr7_+_122671401 14.600 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr9_+_104569671 13.954 ENSMUST00000057742.8
 Cpne4
copine IV
chr7_-_81493725 13.951 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr2_+_132781278 13.798 ENSMUST00000028826.3
 Chgb
chromogranin B
chr7_+_122671378 13.635 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr9_-_57467985 13.381 ENSMUST00000046587.6
 Scamp5
secretory carrier membrane protein 5
chr9_+_104569754 13.367 ENSMUST00000077190.6
 Cpne4
copine IV
chr2_-_181314500 13.137 ENSMUST00000103045.3
 Stmn3
stathmin-like 3
chr12_+_102949450 12.911 ENSMUST00000179002.1
 Unc79
unc-79 homolog (C. elegans)
chr15_-_76722161 12.860 ENSMUST00000049956.4
 Lrrc24
leucine rich repeat containing 24
chr12_-_70347536 12.531 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
 Trim9


tripartite motif-containing 9


chr12_-_84698769 12.513 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr1_-_84696182 12.340 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr17_-_83631892 12.172 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr7_-_81493883 12.042 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr4_-_129121234 11.645 ENSMUST00000030572.3
 Hpca
hippocalcin
chr2_+_155775333 11.296 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr1_+_81077274 9.624 ENSMUST00000068275.5
ENSMUST00000113494.2
 Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr9_+_108826320 9.266 ENSMUST00000024238.5
 Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr19_-_45046614 9.226 ENSMUST00000145391.1
 Pdzd7
PDZ domain containing 7
chr4_+_129136948 9.133 ENSMUST00000102600.3
 Fndc5
fibronectin type III domain containing 5
chr13_-_56895737 9.097 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr7_+_27653906 8.808 ENSMUST00000008088.7
 Ttc9b
tetratricopeptide repeat domain 9B
chrX_+_7638674 8.235 ENSMUST00000128890.1
 Syp
synaptophysin
chr13_-_105054895 8.198 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr11_-_117873433 8.194 ENSMUST00000033230.7
 Tha1
threonine aldolase 1
chr1_+_81077204 7.599 ENSMUST00000123720.1
 Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr17_-_23740301 6.322 ENSMUST00000024702.3
 Paqr4
progestin and adipoQ receptor family member IV
chr8_+_18846251 6.193 ENSMUST00000149565.1
ENSMUST00000033847.4
 Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr12_+_113140198 5.906 ENSMUST00000084882.4
 Crip2
cysteine rich protein 2
chr1_-_193035651 5.622 ENSMUST00000016344.7
 Syt14
synaptotagmin XIV
chr16_-_37384915 5.504 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_-_34579613 5.123 ENSMUST00000062557.3
 1700101I19Rik
RIKEN cDNA 1700101I19 gene
chr9_+_122117375 4.436 ENSMUST00000118886.1
 Snrk
SNF related kinase
chr4_-_153482768 3.972 ENSMUST00000105646.2
 Ajap1
adherens junction associated protein 1
chr9_+_122117258 3.664 ENSMUST00000146832.1
ENSMUST00000139181.1
 Snrk

SNF related kinase

chr9_+_122117338 3.448 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
 Snrk


SNF related kinase


chr8_+_69088646 2.838 ENSMUST00000006435.7
 Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr9_-_22085391 2.790 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr19_+_5038826 2.597 ENSMUST00000053705.6
 B3gnt1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr5_+_104046869 2.248 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr15_-_76521902 2.212 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr6_+_113282302 2.203 ENSMUST00000041203.5
 Cpne9
copine family member IX
chr10_+_90829538 2.094 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr1_-_162548484 2.009 ENSMUST00000028017.9
 Mettl13
methyltransferase like 13
chr16_-_37384940 2.005 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr3_-_89764581 1.955 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr10_+_90829409 1.954 ENSMUST00000182202.1
ENSMUST00000182966.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr13_+_54371340 1.830 ENSMUST00000026985.8
 Cplx2
complexin 2
chr17_-_25240112 1.704 ENSMUST00000038973.6
ENSMUST00000115154.4
 Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr3_-_109027600 1.086 ENSMUST00000171143.1
 Fam102b
family with sequence similarity 102, member B
chr6_-_134887783 1.076 ENSMUST00000066107.6
 Gpr19
G protein-coupled receptor 19
chr11_+_102393403 1.044 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
 Rundc3a



RUN domain containing 3A



chr7_+_63444741 0.888 ENSMUST00000058476.7
 Otud7a
OTU domain containing 7A
chr9_+_40873981 0.880 ENSMUST00000067375.3
 Bsx
brain specific homeobox
chr2_-_180104463 0.812 ENSMUST00000056480.3
 Hrh3
histamine receptor H3
chr2_-_92401237 0.798 ENSMUST00000050312.2
 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_38260372 0.232 ENSMUST00000119047.1
 Tmem128
transmembrane protein 128

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 51.9 GO:1900673 olefin metabolic process(GO:1900673)
8.3 16.7 GO:0021586 pons maturation(GO:0021586)
8.2 73.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
5.6 62.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
5.2 20.8 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
4.5 22.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
4.3 38.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
4.1 24.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
3.9 11.6 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
3.3 13.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
2.8 16.6 GO:0072318 clathrin coat disassembly(GO:0072318)
2.7 8.2 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
2.7 8.2 GO:0006566 threonine metabolic process(GO:0006566)
2.7 27.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
2.1 30.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
1.9 48.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.5 9.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
1.4 16.7 GO:0043084 penile erection(GO:0043084)
1.3 12.9 GO:0048149 behavioral response to ethanol(GO:0048149)
1.2 16.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
1.1 9.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.1 26.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.1 11.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
1.1 28.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.0 4.0 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.9 13.4 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.9 18.7 GO:0071625 vocalization behavior(GO:0071625)
0.8 16.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.8 12.3 GO:0007220 Notch receptor processing(GO:0007220)
0.8 26.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.7 2.2 GO:0046032 ADP catabolic process(GO:0046032)
0.7 2.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.6 1.7 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.6 15.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.4 9.1 GO:0006828 manganese ion transport(GO:0006828)
0.3 4.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.3 0.8 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.2 1.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.2 0.9 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.2 2.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 7.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 12.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 17.0 GO:0007286 spermatid development(GO:0007286)
0.1 0.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 17.2 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 2.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.0 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.1 0.9 GO:0060056 mammary gland involution(GO:0060056)
0.1 16.4 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 12.2 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.1 22.5 GO:0031175 neuron projection development(GO:0031175)
0.1 6.2 GO:0006639 acylglycerol metabolic process(GO:0006639)
0.1 2.8 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.1 2.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 5.6 GO:0006906 vesicle fusion(GO:0006906)
0.0 5.9 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 11.5 GO:0009607 response to biotic stimulus(GO:0009607)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 51.9 GO:0044307 dendritic branch(GO:0044307)
5.6 16.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
5.2 62.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
4.9 73.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
4.1 24.6 GO:0008091 spectrin(GO:0008091)
3.2 22.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.3 28.0 GO:0044294 dendritic growth cone(GO:0044294)
2.3 20.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.3 9.2 GO:0002141 stereocilia ankle link(GO:0002141)
2.2 21.7 GO:0032426 stereocilium tip(GO:0032426)
2.0 26.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
1.7 26.0 GO:0097449 astrocyte projection(GO:0097449)
1.2 11.6 GO:0044327 dendritic spine head(GO:0044327)
1.0 44.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.0 4.0 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.9 1.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.7 24.9 GO:0048786 presynaptic active zone(GO:0048786)
0.6 20.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 19.4 GO:0060077 inhibitory synapse(GO:0060077)
0.4 16.3 GO:0097440 apical dendrite(GO:0097440)
0.3 2.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 16.7 GO:0030667 secretory granule membrane(GO:0030667)
0.2 11.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 9.1 GO:0005801 cis-Golgi network(GO:0005801)
0.2 2.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 12.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 11.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 9.3 GO:0030141 secretory granule(GO:0030141)
0.1 15.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 12.3 GO:0005769 early endosome(GO:0005769)
0.1 9.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 52.7 GO:0005886 plasma membrane(GO:0005886)
0.0 4.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 5.9 GO:0005938 cell cortex(GO:0005938)
0.0 13.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 25.4 GO:0070062 extracellular exosome(GO:0070062)
0.0 60.6 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 73.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
8.6 51.9 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
6.5 26.0 GO:0030348 syntaxin-3 binding(GO:0030348)
4.5 27.2 GO:0033691 sialic acid binding(GO:0033691)
4.2 16.6 GO:0004966 galanin receptor activity(GO:0004966)
3.2 15.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.7 8.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
2.6 26.4 GO:0042301 phosphate ion binding(GO:0042301)
2.1 62.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.7 20.8 GO:0097109 neuroligin family protein binding(GO:0097109)
1.6 48.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.4 22.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.8 9.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.7 13.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.7 28.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.7 12.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 16.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 25.3 GO:0015485 cholesterol binding(GO:0015485)
0.4 1.7 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.4 24.6 GO:0030507 spectrin binding(GO:0030507)
0.4 22.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.3 1.0 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.3 12.3 GO:0005112 Notch binding(GO:0005112)
0.3 6.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 5.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 2.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.2 18.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 32.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 20.0 GO:0000149 SNARE binding(GO:0000149)
0.2 2.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 17.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 11.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 16.0 GO:0005261 cation channel activity(GO:0005261)
0.1 0.8 GO:0008227 G-protein coupled amine receptor activity(GO:0008227)
0.1 11.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 11.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.8 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 6.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 11.6 GO:0003779 actin binding(GO:0003779)
0.0 2.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 2.0 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 27.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.5 73.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.4 16.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 15.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 12.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 11.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 125.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.5 67.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.5 9.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
1.1 16.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.9 28.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.8 16.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.8 11.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.5 16.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 12.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 12.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 6.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 0.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 12.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.8 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation