Motif ID: Rfx2_Rfx7
Z-value: 1.252
Transcription factors associated with Rfx2_Rfx7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rfx2 | ENSMUSG00000024206.8 | Rfx2 |
| Rfx7 | ENSMUSG00000037674.9 | Rfx7 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx2 | mm10_v2_chr17_-_56830916_56831008 | -0.57 | 4.9e-06 | Click! |
| Rfx7 | mm10_v2_chr9_+_72532609_72532828 | -0.15 | 2.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.0 | 4.0 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 1.0 | 5.0 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.9 | 15.3 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.8 | 2.5 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.8 | 2.3 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.8 | 3.1 | GO:2000832 | androgen secretion(GO:0035935) testosterone secretion(GO:0035936) positive regulation of apoptotic DNA fragmentation(GO:1902512) negative regulation of steroid hormone secretion(GO:2000832) regulation of androgen secretion(GO:2000834) regulation of testosterone secretion(GO:2000843) |
| 0.7 | 2.1 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.7 | 2.8 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.6 | 2.4 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.6 | 1.7 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.5 | 2.6 | GO:1904717 | positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.5 | 0.5 | GO:1904526 | regulation of microtubule binding(GO:1904526) |
| 0.5 | 1.5 | GO:0010751 | regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 0.5 | 1.8 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.4 | 4.5 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.4 | 2.2 | GO:0015871 | choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.4 | 1.3 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.4 | 1.2 | GO:1903538 | meiotic sister chromatid cohesion, centromeric(GO:0051754) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.4 | 2.0 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 0.4 | 1.5 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.4 | 1.1 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.4 | 1.4 | GO:0018307 | tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307) |
| 0.3 | 2.0 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.3 | 1.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.3 | 1.3 | GO:0040010 | positive regulation of growth rate(GO:0040010) |
| 0.3 | 1.0 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.3 | 1.9 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.3 | 1.2 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.3 | 1.1 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.3 | 1.4 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.3 | 1.9 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.3 | 1.6 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.3 | 1.8 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.3 | 1.0 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.2 | 0.7 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.2 | 0.9 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.2 | 2.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.2 | 0.7 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
| 0.2 | 1.9 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.2 | 0.6 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.2 | 1.8 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 1.8 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.2 | 0.8 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.2 | 0.8 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 0.2 | 2.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.2 | 0.8 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.2 | 1.2 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.2 | 0.9 | GO:0006537 | glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543) |
| 0.2 | 2.3 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.2 | 1.0 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.2 | 0.7 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.2 | 0.5 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.2 | 0.9 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 1.2 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
| 0.1 | 2.0 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 1.4 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 1.0 | GO:0021886 | female meiosis I(GO:0007144) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) |
| 0.1 | 0.6 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.1 | 1.0 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 2.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 1.3 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.1 | 0.4 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401) |
| 0.1 | 0.4 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
| 0.1 | 0.5 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075) |
| 0.1 | 0.9 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.1 | 5.1 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
| 0.1 | 2.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 4.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.5 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.1 | 0.7 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 3.0 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.5 | GO:1900242 | regulation of synaptic vesicle endocytosis(GO:1900242) |
| 0.1 | 1.3 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.1 | 1.0 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
| 0.1 | 0.3 | GO:1903564 | regulation of protein localization to cilium(GO:1903564) |
| 0.1 | 0.6 | GO:2000370 | positive regulation of clathrin-mediated endocytosis(GO:2000370) |
| 0.1 | 0.6 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 0.1 | 0.7 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.1 | 0.3 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 0.9 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.1 | 1.9 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 3.2 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 1.6 | GO:0006047 | UDP-N-acetylglucosamine metabolic process(GO:0006047) |
| 0.1 | 0.9 | GO:0090148 | membrane fission(GO:0090148) |
| 0.1 | 0.3 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.1 | 0.5 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.1 | 1.1 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 1.7 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) |
| 0.1 | 7.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 1.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 1.5 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 1.2 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 0.9 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 2.4 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.1 | 9.9 | GO:0007631 | feeding behavior(GO:0007631) |
| 0.1 | 0.8 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.8 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.1 | 1.0 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 0.3 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.1 | 0.9 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.1 | 0.7 | GO:0043084 | penile erection(GO:0043084) |
| 0.1 | 3.3 | GO:0007032 | endosome organization(GO:0007032) |
| 0.1 | 0.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 5.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 0.7 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.5 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.1 | 1.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 3.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 0.7 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 2.0 | GO:0002437 | inflammatory response to antigenic stimulus(GO:0002437) |
| 0.1 | 1.1 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.7 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 0.5 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 5.3 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 0.2 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 1.1 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 1.3 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.1 | 0.6 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 0.1 | 1.2 | GO:0033198 | response to ATP(GO:0033198) |
| 0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.3 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 0.3 | GO:0090168 | establishment of Golgi localization(GO:0051683) Golgi reassembly(GO:0090168) |
| 0.1 | 0.3 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.1 | 0.7 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.8 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 0.5 | GO:0010884 | positive regulation of lipid storage(GO:0010884) |
| 0.0 | 0.4 | GO:0034776 | response to histamine(GO:0034776) cellular response to histamine(GO:0071420) |
| 0.0 | 0.4 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 2.5 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 0.2 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.0 | 0.4 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.0 | 1.3 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.0 | 0.8 | GO:0035357 | peroxisome proliferator activated receptor signaling pathway(GO:0035357) |
| 0.0 | 0.7 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.1 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.0 | 3.0 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 2.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.1 | GO:1902953 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) |
| 0.0 | 0.1 | GO:0042182 | ketone catabolic process(GO:0042182) |
| 0.0 | 0.9 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.0 | 0.2 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.0 | 0.1 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.0 | 0.4 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.0 | 0.8 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.0 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.0 | 0.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.1 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.0 | 0.6 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 1.1 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.0 | 1.7 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 0.2 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.5 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.5 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.4 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.5 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.0 | 0.5 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.1 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 0.0 | 0.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.4 | GO:0060438 | trachea development(GO:0060438) |
| 0.0 | 1.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.3 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.2 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 1.6 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.0 | 0.1 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 0.2 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.0 | 0.4 | GO:0097484 | dendrite extension(GO:0097484) |
| 0.0 | 0.4 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.0 | 0.5 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.2 | GO:0046519 | sphingoid metabolic process(GO:0046519) |
| 0.0 | 0.4 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 0.3 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 2.1 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 0.6 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.3 | GO:0014002 | astrocyte development(GO:0014002) |
| 0.0 | 0.4 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.0 | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.4 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 1.0 | 15.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.8 | 5.0 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.8 | 3.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.4 | 2.8 | GO:0070695 | FHF complex(GO:0070695) |
| 0.4 | 1.2 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.4 | 4.0 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.4 | 1.8 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.3 | 1.0 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.3 | 1.6 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.3 | 1.2 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.3 | 3.2 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 0.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.2 | 0.8 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.2 | 6.5 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.2 | 0.7 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.2 | 1.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 1.9 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 1.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 3.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 1.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 4.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 1.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 2.6 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 2.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.4 | GO:0071942 | XPC complex(GO:0071942) |
| 0.1 | 0.8 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 0.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 4.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 0.5 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 2.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.7 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.1 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 0.6 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 0.9 | GO:0030877 | nuclear envelope lumen(GO:0005641) beta-catenin destruction complex(GO:0030877) |
| 0.1 | 3.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.7 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 1.9 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 9.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 5.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.0 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 0.8 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.1 | 1.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.5 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.3 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 0.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 2.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 0.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 0.2 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 5.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 4.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.9 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 2.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.8 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 2.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 1.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.6 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 1.4 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.9 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.1 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 2.8 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 2.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.3 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.8 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 1.4 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 3.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 1.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.3 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 0.6 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.0 | 1.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.8 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 1.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.3 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 0.1 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.0 | GO:0090576 | RNA polymerase III transcription factor complex(GO:0090576) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 15.3 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.9 | 2.8 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.9 | 3.5 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.7 | 2.9 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.7 | 2.6 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.6 | 2.5 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.6 | 3.1 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.5 | 1.6 | GO:0033699 | DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699) |
| 0.5 | 2.1 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.5 | 1.8 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.4 | 4.0 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.3 | 1.0 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.3 | 1.2 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.3 | 2.3 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.3 | 1.4 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.3 | 1.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.3 | 2.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 1.1 | GO:1902379 | chemoattractant activity involved in axon guidance(GO:1902379) |
| 0.3 | 1.4 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
| 0.3 | 2.1 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.3 | 4.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 0.7 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.2 | 1.0 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
| 0.2 | 1.2 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.2 | 3.0 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 2.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 2.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 2.8 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 1.6 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.2 | 1.2 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 0.9 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 1.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 3.0 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 0.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 1.8 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 5.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 0.4 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.1 | 0.4 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 1.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.1 | 0.5 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.1 | 0.8 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 1.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 4.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 0.5 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 1.5 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.9 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 2.0 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.8 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.1 | 0.6 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.1 | 2.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.6 | GO:0005047 | signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312) |
| 0.1 | 1.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 2.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 0.3 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 0.1 | 0.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 5.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 1.3 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 1.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 0.4 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.1 | 0.5 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 0.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 0.4 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.1 | 0.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.4 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.2 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.1 | 2.0 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.1 | 0.1 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.1 | 0.3 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 2.3 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.5 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.7 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.1 | 3.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 0.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 2.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.9 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 1.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.3 | GO:0051429 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.9 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 2.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 1.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.5 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.5 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 0.7 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.4 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 1.1 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 1.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.1 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.0 | 1.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.6 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 1.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.0 | 0.1 | GO:0004335 | galactokinase activity(GO:0004335) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 1.4 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.3 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.0 | 7.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 2.6 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 2.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.2 | GO:0030983 | mismatched DNA binding(GO:0030983) |
| 0.0 | 0.2 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.1 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.0 | 0.1 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.3 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.0 | 0.6 | GO:0035250 | UDP-galactosyltransferase activity(GO:0035250) |
| 0.0 | 0.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 1.1 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 0.1 | GO:0016615 | malate dehydrogenase activity(GO:0016615) |
| 0.0 | 0.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.3 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 0.1 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 0.4 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 6.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.6 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.2 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 7.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 1.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 3.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 3.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.0 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.0 | 0.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.0 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 4.2 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 2.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 4.9 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 2.6 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 2.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.5 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 2.2 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.6 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 0.9 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 1.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.7 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.2 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.0 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 1.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.1 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.0 | ST_GA13_PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.5 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.9 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.0 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.5 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 2.3 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.4 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 0.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.6 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.1 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.3 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.2 | 5.4 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 3.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 5.5 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 15.5 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.1 | 2.0 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 0.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 3.2 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 2.5 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 4.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.8 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 2.3 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.0 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 5.2 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.1 | 0.5 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 0.5 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 1.2 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 0.7 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.1 | 0.9 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.5 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.3 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.8 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.9 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.1 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 0.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 1.1 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.8 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.6 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.4 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.7 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.3 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.4 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 0.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.9 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.5 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.2 | REACTOME_MEIOSIS | Genes involved in Meiosis |
| 0.0 | 0.1 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.1 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
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