Motif ID: Rfx2_Rfx7

Z-value: 1.252

Transcription factors associated with Rfx2_Rfx7:

Gene SymbolEntrez IDGene Name
Rfx2 ENSMUSG00000024206.8 Rfx2
Rfx7 ENSMUSG00000037674.9 Rfx7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx2mm10_v2_chr17_-_56830916_56831008-0.574.9e-06Click!
Rfx7mm10_v2_chr9_+_72532609_72532828-0.152.7e-01Click!


Activity profile for motif Rfx2_Rfx7.

activity profile for motif Rfx2_Rfx7


Sorted Z-values histogram for motif Rfx2_Rfx7

Sorted Z-values for motif Rfx2_Rfx7



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_39005880 7.789 ENSMUST00000169034.1
 Tusc3
tumor suppressor candidate 3
chr5_-_128953303 7.789 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr8_+_39005827 7.527 ENSMUST00000167992.1
 Tusc3
tumor suppressor candidate 3
chr12_+_105336922 5.314 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr5_+_27261916 5.129 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr3_+_156562141 5.043 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1
chr3_+_82358056 4.967 ENSMUST00000091014.4
 Map9
microtubule-associated protein 9
chr7_+_16959714 4.782 ENSMUST00000038163.6
 Pnmal1
PNMA-like 1
chr8_-_54724317 4.665 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
 Wdr17


WD repeat domain 17


chr4_+_129960760 4.491 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr7_-_4546567 4.357 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr13_+_83504032 4.220 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr18_+_75820174 4.199 ENSMUST00000058997.7
 Zbtb7c
zinc finger and BTB domain containing 7C
chr7_-_31051431 4.086 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr11_-_23633621 4.023 ENSMUST00000180260.1
ENSMUST00000141353.1
ENSMUST00000131612.1
ENSMUST00000109532.2
 0610010F05Rik



RIKEN cDNA 0610010F05 gene



chr7_+_4922251 4.022 ENSMUST00000047309.5
 Nat14
N-acetyltransferase 14
chr9_-_53975246 3.999 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr11_+_103649498 3.670 ENSMUST00000057870.2
 Rprml
reprimo-like
chr8_-_54724474 3.544 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr15_-_79834323 3.488 ENSMUST00000177316.2
ENSMUST00000175858.2
 Nptxr

neuronal pentraxin receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 9.9 GO:0007631 feeding behavior(GO:0007631)
0.1 7.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 5.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 5.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 5.1 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
1.0 5.0 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.4 4.5 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 4.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.4 4.2 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.0 4.0 GO:0046898 response to cycloheximide(GO:0046898)
0.1 3.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 3.3 GO:0007032 endosome organization(GO:0007032)
0.1 3.2 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.8 3.1 GO:2000832 androgen secretion(GO:0035935) testosterone secretion(GO:0035936) positive regulation of apoptotic DNA fragmentation(GO:1902512) negative regulation of steroid hormone secretion(GO:2000832) regulation of androgen secretion(GO:2000834) regulation of testosterone secretion(GO:2000843)
0.1 3.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 3.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 2.8 GO:0009957 epidermal cell fate specification(GO:0009957)
0.5 2.6 GO:1904717 positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717)
0.8 2.5 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 15.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 9.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 6.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 5.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.8 5.0 GO:0000235 astral microtubule(GO:0000235)
0.1 4.7 GO:0035371 microtubule plus-end(GO:0035371)
1.1 4.4 GO:1990769 proximal neuron projection(GO:1990769)
0.0 4.3 GO:0030017 sarcomere(GO:0030017)
0.1 4.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.4 4.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 4.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.4 GO:0001726 ruffle(GO:0001726)
0.3 3.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 3.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 3.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 2.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 2.8 GO:0070695 FHF complex(GO:0070695)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 15.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 7.9 GO:0008017 microtubule binding(GO:0008017)
0.0 7.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 6.6 GO:0003779 actin binding(GO:0003779)
0.1 5.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 5.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 4.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 4.2 GO:0003680 AT DNA binding(GO:0003680)
0.4 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.9 3.5 GO:0001847 opsonin receptor activity(GO:0001847)
0.6 3.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 3.1 GO:0030276 clathrin binding(GO:0030276)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 3.0 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 3.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 3.0 GO:0005096 GTPase activator activity(GO:0005096)
0.7 2.9 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 2.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.9 2.8 GO:0005119 smoothened binding(GO:0005119)
0.2 2.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 4.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 3.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 2.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 2.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.5 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 5.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 5.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 5.2 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 4.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 4.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 3.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 2.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell