Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 2.899

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx4mm10_v2_chr10_+_84756055_84756084-0.516.1e-05Click!
Rfx1mm10_v2_chr8_+_84066824_84066882-0.293.3e-02Click!
Rfx3mm10_v2_chr19_-_28010995_280110540.028.8e-01Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_60925612 27.768 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chrX_+_7919816 26.151 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr15_+_98167806 24.110 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr7_-_140082246 18.937 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr7_-_31051431 18.669 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr4_-_119415494 18.524 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr5_+_24985840 18.358 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr7_-_140082489 18.084 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr7_-_4546567 14.442 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr7_+_99268338 14.126 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr9_+_59589288 14.068 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr11_-_105944412 13.785 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr12_-_84148449 13.598 ENSMUST00000061425.2
 Pnma1
paraneoplastic antigen MA1
chr10_-_81472859 13.512 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr1_-_60043087 13.039 ENSMUST00000027172.6
 Ica1l
islet cell autoantigen 1-like
chr17_+_34629533 12.918 ENSMUST00000015620.6
 Prrt1
proline-rich transmembrane protein 1
chr15_+_54745702 11.912 ENSMUST00000050027.8
 Nov
nephroblastoma overexpressed gene
chr11_-_105944128 11.409 ENSMUST00000184086.1
 Cyb561
cytochrome b-561
chr19_-_57197435 11.208 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 11.026 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 44.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.5 41.6 GO:0030032 lamellipodium assembly(GO:0030032)
1.4 39.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 26.7 GO:0022900 electron transport chain(GO:0022900)
1.4 26.2 GO:0016486 peptide hormone processing(GO:0016486)
2.8 19.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.6 19.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.9 19.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.9 19.3 GO:0071625 vocalization behavior(GO:0071625)
0.8 19.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
3.6 17.8 GO:0032423 regulation of mismatch repair(GO:0032423)
3.5 17.4 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 16.6 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.8 16.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.3 14.6 GO:0032418 lysosome localization(GO:0032418)
0.2 13.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.5 13.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 12.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
4.0 11.9 GO:1990523 negative regulation of SMAD protein import into nucleus(GO:0060392) endothelial cell-cell adhesion(GO:0071603) bone regeneration(GO:1990523)
0.5 11.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.2 GO:0016021 integral component of membrane(GO:0016021)
0.4 46.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 39.7 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.2 37.9 GO:0030141 secretory granule(GO:0030141)
10.8 32.4 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 28.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
7.0 28.1 GO:1990769 proximal neuron projection(GO:1990769)
0.1 21.0 GO:0060076 excitatory synapse(GO:0060076)
0.6 17.8 GO:0035371 microtubule plus-end(GO:0035371)
0.5 17.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.9 17.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.6 14.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 14.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 13.2 GO:0031430 M band(GO:0031430)
1.0 12.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 12.8 GO:0016607 nuclear speck(GO:0016607)
0.1 12.7 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.5 11.9 GO:0005921 gap junction(GO:0005921)
1.2 11.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 10.7 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 37.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 35.1 GO:0008017 microtubule binding(GO:0008017)
3.6 32.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 30.3 GO:0003779 actin binding(GO:0003779)
0.3 28.3 GO:0016247 channel regulator activity(GO:0016247)
0.6 26.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
8.4 25.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.5 22.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 20.4 GO:0017080 sodium channel regulator activity(GO:0017080)
4.9 19.7 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
5.9 17.8 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.6 17.4 GO:0032183 SUMO binding(GO:0032183)
0.3 13.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 13.5 GO:0005246 calcium channel regulator activity(GO:0005246)
1.5 12.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.6 11.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 11.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 11.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 11.4 GO:0008013 beta-catenin binding(GO:0008013)
1.4 11.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 32.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 17.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 16.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 15.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 13.5 PID_FOXO_PATHWAY FoxO family signaling
0.1 11.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 10.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 10.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 9.6 PID_LKB1_PATHWAY LKB1 signaling events
0.3 7.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 7.3 PID_P73PATHWAY p73 transcription factor network
0.2 6.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 6.2 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 5.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 3.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 70.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
1.6 44.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 26.0 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.6 20.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.7 19.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 13.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 10.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 9.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.6 9.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 7.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2 7.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 7.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 6.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 6.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 5.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 5.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 4.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 4.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 4.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 4.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides