Motif ID: Rfx5

Z-value: 0.628


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.284.1e-02Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 61 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_37376359 7.248 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr7_-_105752193 4.533 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_-_45092130 4.326 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 4.079 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr11_+_117523526 3.636 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr17_+_35861318 3.474 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr7_-_30664986 3.413 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr11_-_3539228 3.110 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr5_+_139150211 2.644 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr17_+_35861343 2.607 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr8_+_94214567 2.439 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr11_+_61505138 2.308 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr4_-_116627921 1.949 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr1_-_183147461 1.917 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr7_+_100537192 1.886 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr7_+_100537052 1.881 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_4615647 1.783 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr19_-_10482874 1.744 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr5_-_36830647 1.611 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr18_-_51865881 1.459 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 4.5 GO:0043171 peptide catabolic process(GO:0043171)
0.2 3.8 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 3.4 GO:0051225 spindle assembly(GO:0051225)
0.0 2.9 GO:0016579 protein deubiquitination(GO:0016579)
0.5 2.4 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 2.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.5 2.0 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.2 1.9 GO:0060539 diaphragm development(GO:0060539)
0.1 1.9 GO:0043486 histone exchange(GO:0043486)
0.2 1.6 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.6 GO:0034341 response to interferon-gamma(GO:0034341)
0.0 1.4 GO:0007338 single fertilization(GO:0007338)
0.3 1.3 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.3 1.3 GO:0002339 B cell selection(GO:0002339)
0.1 1.2 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.4 1.1 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.1 1.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.2 0.9 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 7.2 GO:0005876 spindle microtubule(GO:0005876)
0.3 6.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 3.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 3.4 GO:0070652 HAUS complex(GO:0070652)
0.3 3.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.4 GO:0005643 nuclear pore(GO:0005643)
0.1 2.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.4 GO:0016235 aggresome(GO:0016235)
0.1 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 0.5 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.1 4.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 2.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.8 2.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.2 2.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 1.9 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 1.4 GO:0030145 manganese ion binding(GO:0030145)
0.3 1.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.3 GO:1990405 protein antigen binding(GO:1990405)
0.2 1.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 1.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.9 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network