Motif ID: Rora

Z-value: 0.776


Transcription factors associated with Rora:

Gene SymbolEntrez IDGene Name
Rora ENSMUSG00000032238.11 Rora

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Roramm10_v2_chr9_+_68653761_686537860.114.2e-01Click!


Activity profile for motif Rora.

activity profile for motif Rora


Sorted Z-values histogram for motif Rora

Sorted Z-values for motif Rora



Network of associatons between targets according to the STRING database.



First level regulatory network of Rora

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 11.032 ENSMUST00000168589.1
 Sla
src-like adaptor
chr1_+_159737510 5.372 ENSMUST00000111669.3
 Tnr
tenascin R
chr9_-_75597643 5.232 ENSMUST00000164100.1
 Tmod2
tropomodulin 2
chr11_+_42419729 4.950 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr2_-_5676046 4.743 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr3_-_107517321 4.265 ENSMUST00000166892.1
 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr16_+_11406618 4.245 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr5_+_37028329 4.209 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr19_-_57314896 4.089 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr11_+_97450136 3.926 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr2_+_4300462 3.919 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr7_-_12422751 3.864 ENSMUST00000080348.5
 Zfp551
zinc fingr protein 551
chr19_-_37207293 3.781 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr5_-_106696819 3.466 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
 Zfp644


zinc finger protein 644


chr15_-_72546279 3.141 ENSMUST00000044624.6
 Kcnk9
potassium channel, subfamily K, member 9
chr2_+_170731807 3.082 ENSMUST00000029075.4
 Dok5
docking protein 5
chr19_-_46327121 3.016 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr7_-_31126945 2.999 ENSMUST00000098548.4
 Scn1b
sodium channel, voltage-gated, type I, beta
chr1_+_32172711 2.991 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr5_-_106696530 2.937 ENSMUST00000137285.1
ENSMUST00000124263.1
ENSMUST00000112695.1
ENSMUST00000155495.1
ENSMUST00000135108.1
 Zfp644




zinc finger protein 644





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.6 7.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
1.3 5.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 5.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.9 5.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.6 5.0 GO:0071420 cellular response to histamine(GO:0071420)
0.7 4.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.9 4.3 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.4 3.9 GO:0036376 sodium ion export from cell(GO:0036376)
0.2 3.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 3.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.7 3.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.3 3.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 3.1 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 3.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
1.0 3.0 GO:0071929 alpha-tubulin acetylation(GO:0071929)
1.0 3.0 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 3.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.9 GO:0051693 actin filament capping(GO:0051693)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 8.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 5.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 5.5 GO:0008021 synaptic vesicle(GO:0008021)
1.8 5.4 GO:0072534 perineuronal net(GO:0072534)
0.1 5.1 GO:0031594 neuromuscular junction(GO:0031594)
0.3 5.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.2 GO:0031965 nuclear membrane(GO:0031965)
0.6 3.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 3.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.9 GO:0019898 extrinsic component of membrane(GO:0019898)
0.3 3.0 GO:0097427 microtubule bundle(GO:0097427)
0.2 3.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.0 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.6 2.9 GO:0032437 cuticular plate(GO:0032437)
0.0 2.9 GO:0045177 apical part of cell(GO:0045177)
0.3 2.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.5 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 8.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 6.7 GO:0005096 GTPase activator activity(GO:0005096)
0.3 5.4 GO:0046625 sphingolipid binding(GO:0046625)
0.6 5.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 5.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 5.1 GO:0030507 spectrin binding(GO:0030507)
1.2 5.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 4.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 4.5 GO:0030674 protein binding, bridging(GO:0030674)
0.3 4.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 4.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 4.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 3.9 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.2 3.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 3.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 3.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 3.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 5.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 5.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 5.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 4.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 3.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 3.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 3.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 3.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 2.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.1 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 2.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.7 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.2 1.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle