Motif ID: Rora
Z-value: 0.776
Transcription factors associated with Rora:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rora | ENSMUSG00000032238.11 | Rora |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rora | mm10_v2_chr9_+_68653761_68653786 | 0.11 | 4.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.7 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 1.3 | 5.4 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.0 | 3.0 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 1.0 | 3.0 | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
| 0.9 | 2.8 | GO:0021933 | radial glia guided migration of cerebellar granule cell(GO:0021933) |
| 0.9 | 5.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.9 | 4.3 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.8 | 2.5 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.7 | 3.7 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.7 | 2.2 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.7 | 2.1 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.7 | 4.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.6 | 2.3 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.6 | 1.7 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.6 | 5.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.5 | 1.6 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.5 | 2.1 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.5 | 2.0 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.5 | 2.5 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.5 | 1.5 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.4 | 2.6 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.4 | 1.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.4 | 3.9 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.4 | 2.8 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.4 | 1.4 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.3 | 1.0 | GO:0006550 | isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952) |
| 0.3 | 3.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.3 | 1.4 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.3 | 2.0 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.3 | 2.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.2 | 2.2 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.2 | 1.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.2 | 1.6 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.2 | 1.8 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.2 | 1.3 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
| 0.2 | 3.9 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.2 | 3.1 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.2 | 1.4 | GO:0046103 | inosine biosynthetic process(GO:0046103) |
| 0.2 | 2.8 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.2 | 0.9 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.2 | 0.5 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.2 | 0.5 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.2 | 1.2 | GO:0021886 | hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) |
| 0.2 | 11.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 1.1 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.2 | 3.1 | GO:0007183 | SMAD protein complex assembly(GO:0007183) |
| 0.2 | 1.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 0.5 | GO:0097212 | cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) |
| 0.2 | 1.9 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.2 | 1.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 0.6 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.1 | 0.4 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
| 0.1 | 1.0 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 0.6 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 0.9 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.1 | 1.0 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 3.0 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 2.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 3.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 2.0 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 0.1 | 5.3 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 0.8 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 0.5 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.1 | 2.9 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.1 | 0.8 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.1 | 0.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.8 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 2.0 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 1.9 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 0.5 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 0.1 | 1.2 | GO:0048011 | neurotrophin TRK receptor signaling pathway(GO:0048011) |
| 0.1 | 0.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.4 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 0.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.1 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.0 | 1.3 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 2.1 | GO:0051647 | nucleus localization(GO:0051647) |
| 0.0 | 0.4 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 1.3 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
| 0.0 | 2.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 3.1 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
| 0.0 | 0.1 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
| 0.0 | 0.4 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.5 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.0 | 0.4 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
| 0.0 | 0.6 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
| 0.0 | 1.9 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 2.5 | GO:0007088 | regulation of mitotic nuclear division(GO:0007088) |
| 0.0 | 0.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.2 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) |
| 0.0 | 0.1 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 1.4 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.5 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.0 | 0.3 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 2.4 | GO:0008361 | regulation of cell size(GO:0008361) |
| 0.0 | 1.3 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.0 | 0.3 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 1.0 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 2.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 1.7 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.6 | 2.9 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.6 | 3.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.5 | 2.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.4 | 3.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.4 | 1.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.4 | 8.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.3 | 3.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.3 | 5.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.3 | 2.8 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 1.4 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.3 | 1.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 1.0 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.2 | 1.1 | GO:1902710 | G-protein coupled receptor heterodimeric complex(GO:0038039) GABA receptor complex(GO:1902710) |
| 0.2 | 3.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.2 | 1.4 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.2 | 2.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 2.0 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.6 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 1.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 2.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 11.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.6 | GO:0097413 | Lewy body(GO:0097413) |
| 0.1 | 1.0 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 0.6 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 5.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 2.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 1.3 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.5 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 0.3 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 2.0 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 1.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 5.6 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 2.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 3.9 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 4.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 2.9 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 0.1 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 3.0 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 0.4 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 1.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.1 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 5.0 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.8 | 2.5 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.7 | 2.0 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.6 | 8.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.6 | 5.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.5 | 1.6 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.5 | 3.0 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.5 | 2.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.4 | 2.2 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.4 | 3.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.4 | 3.9 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.4 | 14.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 2.1 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.3 | 2.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.3 | 5.4 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.3 | 2.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.3 | 0.9 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.3 | 3.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.3 | 2.5 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.3 | 4.3 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.2 | 1.0 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.2 | 1.9 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.2 | 1.4 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.2 | 3.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.2 | 1.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.2 | 3.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 1.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 0.8 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 4.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 3.2 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 0.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 1.7 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 5.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 0.4 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 1.8 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.1 | 0.9 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.1 | 3.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 2.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 5.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.1 | 1.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 2.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 0.8 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 1.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 1.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 2.0 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 0.7 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 1.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 4.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 4.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.9 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 0.9 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 3.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.5 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 1.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 1.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.1 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
| 0.0 | 1.4 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 2.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 4.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.7 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.1 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 6.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 1.2 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 2.6 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 2.1 | GO:0008514 | organic anion transmembrane transporter activity(GO:0008514) |
| 0.0 | 0.5 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.4 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.1 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.7 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.0 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.9 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 3.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.9 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 0.4 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.8 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 6.4 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 2.9 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.2 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.2 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.7 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.5 | PID_VEGFR1_PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.5 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.8 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.8 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 3.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | PID_FGF_PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.1 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.4 | 1.3 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 5.0 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 8.6 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 5.8 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 2.5 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 4.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 3.9 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 2.0 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.2 | 1.6 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 2.1 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 2.6 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 2.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 3.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.1 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 2.5 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.1 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 3.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.1 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 1.0 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.1 | 1.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.3 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 0.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 3.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 0.4 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 1.7 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.5 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.2 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 1.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.4 | REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 0.9 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.4 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.8 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 0.5 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.7 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
