Motif ID: Rorc_Nr1d1

Z-value: 0.442

Transcription factors associated with Rorc_Nr1d1:

Gene SymbolEntrez IDGene Name
Nr1d1 ENSMUSG00000020889.11 Nr1d1
Rorc ENSMUSG00000028150.8 Rorc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1d1mm10_v2_chr11_-_98775333_98775354-0.358.4e-03Click!
Rorcmm10_v2_chr3_+_94377505_943775270.293.4e-02Click!


Activity profile for motif Rorc_Nr1d1.

activity profile for motif Rorc_Nr1d1


Sorted Z-values histogram for motif Rorc_Nr1d1

Sorted Z-values for motif Rorc_Nr1d1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rorc_Nr1d1

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_14310198 2.576 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr12_-_34528844 2.219 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr7_-_79386943 2.003 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr10_+_57784859 1.506 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr14_-_54577578 1.452 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr15_-_65014904 1.297 ENSMUST00000110100.2
 Gm21961
predicted gene, 21961
chr11_+_94327984 1.258 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr15_-_50882806 1.241 ENSMUST00000184885.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr11_-_84069179 1.174 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr5_+_64803513 1.103 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr11_+_94328242 1.101 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr5_+_64970069 1.088 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr7_+_45705088 1.041 ENSMUST00000080885.3
 Dbp
D site albumin promoter binding protein
chr6_-_93913678 0.930 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_+_6548154 0.904 ENSMUST00000021611.8
 Pitrm1
pitrilysin metallepetidase 1
chr11_+_88718442 0.861 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr3_-_101307079 0.794 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chr4_+_11579647 0.790 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chrX_+_103422010 0.745 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr1_+_6734827 0.712 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 2.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.2 1.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.5 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.5 GO:0007601 visual perception(GO:0007601)
0.0 1.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 1.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 0.7 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
0.2 0.7 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.6 GO:0051567 histone H3-K9 methylation(GO:0051567)
0.2 0.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.4 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.4 GO:0050901 leukocyte tethering or rolling(GO:0050901)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.2 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.1 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 2.0 GO:0019841 retinol binding(GO:0019841)
0.1 1.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.2 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 0.7 GO:0051378 serotonin binding(GO:0051378)
0.1 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.4 GO:0034979 NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.1 0.3 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.7 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.5 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions