Motif ID: Rreb1

Z-value: 1.106


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_37826315-0.038.2e-01Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586520 10.140 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr15_+_83791939 10.094 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_+_67586675 9.847 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr13_+_43615710 8.514 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr14_-_34201604 7.623 ENSMUST00000096019.2
 Gprin2
G protein regulated inducer of neurite outgrowth 2
chr7_+_5056856 7.585 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr7_+_5056706 7.251 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr5_+_37047464 6.803 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr14_+_68083853 6.704 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr13_+_109632760 6.692 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr11_-_69369377 6.488 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr3_+_55461758 6.364 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr16_-_67620880 6.110 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chrX_+_7919816 6.066 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr5_-_89883321 5.764 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr3_+_96181151 5.748 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chr7_-_98178254 5.612 ENSMUST00000040971.7
 Capn5
calpain 5
chr11_-_70229677 5.604 ENSMUST00000153449.1
ENSMUST00000000326.5
 Bcl6b

B cell CLL/lymphoma 6, member B

chr16_-_67620805 5.591 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr4_-_141598206 5.506 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.0 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.6 13.4 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 12.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.2 9.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.3 9.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.7 9.1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
1.4 8.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 8.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.6 8.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
1.4 7.2 GO:0034436 glycoprotein transport(GO:0034436)
0.6 7.2 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.3 6.8 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
2.2 6.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 6.7 GO:0016567 protein ubiquitination(GO:0016567)
0.4 6.4 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.3 6.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 6.1 GO:0007098 centrosome cycle(GO:0007098)
1.2 5.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
1.4 5.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.8 5.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.6 GO:0005884 actin filament(GO:0005884)
0.7 15.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
3.2 12.7 GO:1990769 proximal neuron projection(GO:1990769)
0.1 11.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 10.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 7.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 7.3 GO:0000139 Golgi membrane(GO:0000139)
0.6 7.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
2.2 6.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 6.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 6.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 6.0 GO:0098984 neuron to neuron synapse(GO:0098984)
0.1 5.8 GO:0005581 collagen trimer(GO:0005581)
0.2 5.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 5.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.2 GO:0042641 actomyosin(GO:0042641)
0.4 5.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 5.1 GO:0044306 neuron projection terminus(GO:0044306)
0.0 5.1 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 GO:0008017 microtubule binding(GO:0008017)
0.1 13.0 GO:0051015 actin filament binding(GO:0051015)
0.3 9.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 9.8 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.3 9.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
2.3 9.4 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.2 9.4 GO:0097322 7SK snRNA binding(GO:0097322)
1.3 8.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
2.5 7.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
2.4 7.2 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.4 6.8 GO:0050811 GABA receptor binding(GO:0050811)
0.3 6.7 GO:0043274 phospholipase binding(GO:0043274)
0.2 6.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 6.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 5.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.4 5.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 5.5 GO:0031005 filamin binding(GO:0031005)
0.4 5.3 GO:0050897 cobalt ion binding(GO:0050897)
1.0 5.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3 4.6 GO:0031402 sodium ion binding(GO:0031402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 7.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 6.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 4.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.2 3.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.8 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 3.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 3.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 2.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.4 PID_EPO_PATHWAY EPO signaling pathway
0.1 2.4 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 10.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 7.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 6.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 6.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 6.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 6.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 5.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 5.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 5.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 4.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 4.4 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 4.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 3.8 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 3.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels