Motif ID: Runx1
Z-value: 0.836
Transcription factors associated with Runx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Runx1 | ENSMUSG00000022952.10 | Runx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 10.6 | GO:0019532 | oxalate transport(GO:0019532) |
| 1.3 | 3.8 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.9 | 5.6 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
| 0.9 | 3.8 | GO:0035937 | androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864) |
| 0.9 | 4.6 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.9 | 4.4 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 0.8 | 2.4 | GO:0010752 | signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.6 | 2.3 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.5 | 3.6 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.5 | 5.0 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
| 0.4 | 2.5 | GO:0046103 | ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103) |
| 0.4 | 1.9 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.4 | 3.4 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.4 | 1.5 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.4 | 2.5 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.3 | 3.0 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.3 | 2.6 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.3 | 1.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.3 | 1.6 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.2 | 2.0 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.2 | 16.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 0.7 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.2 | 8.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 1.0 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.2 | 3.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.2 | 2.1 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 1.1 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.2 | 1.4 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.1 | 1.6 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 1.9 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.1 | 0.4 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.1 | 6.1 | GO:0040018 | positive regulation of multicellular organism growth(GO:0040018) |
| 0.1 | 0.5 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.1 | 0.4 | GO:0006597 | spermine biosynthetic process(GO:0006597) spermidine biosynthetic process(GO:0008295) |
| 0.1 | 0.7 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
| 0.1 | 0.4 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.1 | 2.6 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.1 | 1.6 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.1 | 1.2 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 3.7 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.7 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 0.3 | GO:2000318 | positive regulation of interferon-gamma secretion(GO:1902715) positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.1 | 0.8 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.1 | 8.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 4.0 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 1.1 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.7 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.0 | 0.2 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.0 | 2.8 | GO:0015807 | L-amino acid transport(GO:0015807) |
| 0.0 | 1.4 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.5 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
| 0.0 | 3.7 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.0 | 0.3 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.0 | 3.2 | GO:0015992 | proton transport(GO:0015992) |
| 0.0 | 3.7 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.0 | 0.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 0.1 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.0 | 0.8 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 3.8 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.4 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.0 | 0.7 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 1.5 | GO:0007416 | synapse assembly(GO:0007416) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.6 | 2.5 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.3 | 2.5 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.3 | 1.1 | GO:0031673 | H zone(GO:0031673) |
| 0.3 | 2.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 5.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 2.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 2.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 1.0 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.1 | 16.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.5 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 0.4 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.1 | 3.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 3.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 5.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 1.6 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.1 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 10.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.0 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 1.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 0.8 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 3.2 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.1 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 7.5 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.1 | GO:0004952 | dopamine neurotransmitter receptor activity(GO:0004952) |
| 1.4 | 5.6 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 1.0 | 10.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.9 | 3.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.4 | 17.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 3.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.3 | 1.8 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.3 | 2.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.3 | 5.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 1.5 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.2 | 2.5 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.2 | 1.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 0.7 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.2 | 3.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.2 | 2.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 2.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 3.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 1.6 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 5.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 0.7 | GO:0042979 | ornithine decarboxylase regulator activity(GO:0042979) |
| 0.1 | 1.1 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 4.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 3.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 4.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.4 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.1 | 7.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 9.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.9 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 4.1 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.1 | 1.8 | GO:0035250 | UDP-galactosyltransferase activity(GO:0035250) |
| 0.1 | 0.4 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.1 | 3.0 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 1.0 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.1 | 3.3 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 2.5 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 2.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.5 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.4 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.0 | 3.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 2.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 4.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 5.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.1 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.3 | GO:0035613 | RNA stem-loop binding(GO:0035613) retinoid X receptor binding(GO:0046965) |
| 0.0 | 2.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 3.8 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.8 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 8.1 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.1 | 9.6 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 5.0 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.1 | 3.6 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 4.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 16.0 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.8 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 3.4 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 6.6 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.6 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 2.6 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.6 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.1 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.4 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.5 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.5 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.6 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 4.1 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 5.0 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 4.0 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 2.4 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.2 | 3.8 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 2.9 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 3.6 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 13.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.8 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 1.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 9.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 3.6 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 2.5 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 3.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.9 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 2.1 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 0.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 3.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.8 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.8 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.7 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 2.5 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.4 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.1 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
