Motif ID: Runx1

Z-value: 0.836


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 17.696 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_+_3397189 8.912 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr16_+_42907563 6.440 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr13_+_76579670 6.153 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr2_+_37516618 6.124 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr4_-_14621805 5.524 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr8_-_11008458 5.010 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr12_-_25096080 4.602 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr1_-_169747634 4.508 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr14_-_124677089 4.443 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chr15_-_76090013 4.271 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr13_+_49608030 4.145 ENSMUST00000021822.5
 Ogn
osteoglycin
chr15_-_37459327 3.976 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chrX_+_151344171 3.946 ENSMUST00000073364.5
 Fam120c
family with sequence similarity 120, member C
chr3_-_107760221 3.850 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chrX_+_159697308 3.803 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr17_+_35236556 3.772 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr5_+_104435112 3.757 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr6_+_17491216 3.619 ENSMUST00000080469.5
 Met
met proto-oncogene
chr11_-_83649349 3.425 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.5 10.6 GO:0019532 oxalate transport(GO:0019532)
0.2 8.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 8.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 6.1 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.9 5.6 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.5 5.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.9 4.6 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.9 4.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 4.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.3 3.8 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.9 3.8 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.1 3.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 3.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 3.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.5 3.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 3.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.2 3.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 3.2 GO:0015992 proton transport(GO:0015992)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 10.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.5 GO:0000785 chromatin(GO:0000785)
0.2 5.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 5.6 GO:0072562 blood microparticle(GO:0072562)
1.3 3.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 3.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.2 GO:0030139 endocytic vesicle(GO:0030139)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 2.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.6 2.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 2.5 GO:0001520 outer dense fiber(GO:0001520)
0.1 2.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.6 GO:0005844 polysome(GO:0005844)
0.0 1.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.3 1.1 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 10.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 9.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.7 GO:0005125 cytokine activity(GO:0005125)
1.5 6.1 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.3 5.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.4 5.6 GO:0001851 complement component C3b binding(GO:0001851)
0.1 5.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 5.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.8 GO:0008017 microtubule binding(GO:0008017)
0.1 4.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.1 GO:0008083 growth factor activity(GO:0008083)
0.1 4.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 3.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 3.8 GO:0044325 ion channel binding(GO:0044325)
0.0 3.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.2 3.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.9 3.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 3.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 3.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 9.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 8.1 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 6.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.0 PID_EPO_PATHWAY EPO signaling pathway
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 3.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 3.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 3.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.6 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 9.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.1 5.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 5.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 4.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 4.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 3.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 3.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.5 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.2 2.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases