Motif ID: Runx3

Z-value: 0.657


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_20181773 7.730 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr13_-_22041352 5.566 ENSMUST00000102977.2
 Hist1h4i
histone cluster 1, H4i
chr13_+_51645232 4.416 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr2_-_71546745 3.996 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr13_-_23551648 3.787 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chrX_+_99136119 3.449 ENSMUST00000052839.6
 Efnb1
ephrin B1
chr13_-_23698454 3.351 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c
chr18_-_47368446 3.122 ENSMUST00000076043.6
ENSMUST00000135790.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr13_-_21832194 3.082 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr2_+_72476159 2.978 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr2_+_72476225 2.873 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr11_-_89302545 2.854 ENSMUST00000061728.3
 Nog
noggin
chr19_-_36736653 2.751 ENSMUST00000087321.2
 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr3_-_154330543 2.675 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr17_+_27556668 2.580 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556613 2.576 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 2.467 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr13_+_21735055 2.304 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr7_+_141216626 2.147 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr2_+_145785980 2.124 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 17.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 7.6 GO:0006284 base-excision repair(GO:0006284)
0.1 4.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.3 4.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 3.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.4 GO:0031295 T cell costimulation(GO:0031295)
0.1 3.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.7 2.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0 2.7 GO:0021884 forebrain neuron development(GO:0021884)
0.1 2.5 GO:0060009 Sertoli cell development(GO:0060009)
0.0 2.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 1.9 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 1.6 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.2 1.5 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 1.5 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.5 1.4 GO:0014891 striated muscle atrophy(GO:0014891)
0.5 1.4 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 1.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.3 1.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.3 1.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.3 GO:0000788 nuclear nucleosome(GO:0000788)
1.1 7.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 4.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.1 GO:0000786 nucleosome(GO:0000786)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 2.8 GO:0042587 glycogen granule(GO:0042587)
0.4 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.4 GO:0042788 polysomal ribosome(GO:0042788)
0.6 1.9 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.5 1.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 1.4 GO:0045120 pronucleus(GO:0045120)
0.1 1.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 1.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.9 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.0 GO:0042393 histone binding(GO:0042393)
0.8 7.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 4.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 4.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 4.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 3.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 2.9 GO:0019955 cytokine binding(GO:0019955)
0.0 2.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.6 1.9 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.2 1.6 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 1.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.2 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.2 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 1.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
1.0 7.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 4.3 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 1.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 1.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 0.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)