Motif ID: Rxra

Z-value: 0.518


Transcription factors associated with Rxra:

Gene SymbolEntrez IDGene Name
Rxra ENSMUSG00000015846.8 Rxra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxramm10_v2_chr2_+_27677201_27677229-0.592.0e-06Click!


Activity profile for motif Rxra.

activity profile for motif Rxra


Sorted Z-values histogram for motif Rxra

Sorted Z-values for motif Rxra



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxra

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_85205120 3.208 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr4_+_85205417 2.726 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr6_+_71707561 2.482 ENSMUST00000121469.1
 Reep1
receptor accessory protein 1
chr6_+_8259327 2.390 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr7_+_30169861 2.219 ENSMUST00000085668.4
 Gm5113
predicted gene 5113
chr13_+_13590402 2.176 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr11_+_75531690 1.868 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr2_+_121357714 1.798 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr13_+_18948344 1.797 ENSMUST00000003345.7
 Amph
amphiphysin
chr7_-_14562171 1.675 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr2_-_59160644 1.572 ENSMUST00000077687.5
 Ccdc148
coiled-coil domain containing 148
chr8_+_12947935 1.515 ENSMUST00000110871.1
 Mcf2l
mcf.2 transforming sequence-like
chr2_+_3770673 1.454 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr1_+_34801704 1.441 ENSMUST00000047664.9
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr5_-_137600650 1.362 ENSMUST00000111007.1
ENSMUST00000133705.1
 Mospd3

motile sperm domain containing 3

chr11_+_4620067 1.358 ENSMUST00000109941.1
 Gm11032
predicted gene 11032
chr15_-_95528702 1.354 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr8_-_99416397 1.306 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr5_-_143895025 1.267 ENSMUST00000079624.5
ENSMUST00000110717.2
 Ankrd61

ankyrin repeat domain 61

chr17_-_35909626 1.244 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.9 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 2.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 2.5 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 2.5 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.8 2.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.7 2.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 1.9 GO:0015807 L-amino acid transport(GO:0015807)
0.0 1.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.8 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.7 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.1 1.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 1.4 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.4 GO:0032091 negative regulation of protein binding(GO:0032091)
0.3 1.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 1.1 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.2 1.1 GO:1904717 positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717)
0.1 1.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 1.1 GO:0009409 response to cold(GO:0009409)
0.1 1.0 GO:0032264 IMP salvage(GO:0032264)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0005769 early endosome(GO:0005769)
0.1 4.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.1 2.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 2.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.3 1.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.1 GO:0016460 myosin II complex(GO:0016460)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.2 0.9 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:1990130 Iml1 complex(GO:1990130)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 1.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 1.8 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 1.4 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 1.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 1.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 1.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.3 1.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 1.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.9 GO:1990405 protein antigen binding(GO:1990405)
0.1 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID_TRAIL_PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.4 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.4 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.1 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism