Motif ID: Rxrb
Z-value: 0.700
Transcription factors associated with Rxrb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rxrb | ENSMUSG00000039656.10 | Rxrb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrb | mm10_v2_chr17_+_34032348_34032401 | 0.12 | 3.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 10.1 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 1.6 | 8.0 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 1.6 | 8.0 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 1.1 | 4.4 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.9 | 5.6 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.9 | 5.5 | GO:0043654 | skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654) |
| 0.5 | 1.6 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.5 | 3.8 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.5 | 5.5 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.4 | 1.8 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905024) |
| 0.4 | 1.2 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.4 | 1.9 | GO:0051890 | regulation of cardioblast differentiation(GO:0051890) |
| 0.4 | 5.3 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.4 | 2.5 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.3 | 1.0 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.3 | 3.7 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.3 | 3.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.3 | 1.6 | GO:1904587 | response to glycoprotein(GO:1904587) |
| 0.3 | 2.6 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.3 | 3.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 0.7 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.2 | 0.7 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.2 | 1.3 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.2 | 2.8 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 1.4 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
| 0.2 | 1.0 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 1.6 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.1 | 0.4 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.1 | 2.2 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.7 | GO:0021539 | subthalamus development(GO:0021539) |
| 0.1 | 3.1 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.1 | 0.9 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 2.0 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 5.7 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.1 | 0.3 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.1 | 2.2 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.1 | 0.6 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 0.9 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 1.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 0.2 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.1 | 1.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.2 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.0 | 0.3 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 1.0 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 0.6 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 0.1 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 0.0 | 0.4 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 3.9 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.5 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.4 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.1 | GO:1903275 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795) |
| 0.0 | 0.2 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.0 | 0.4 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 0.1 | GO:0060347 | heart trabecula formation(GO:0060347) amyloid fibril formation(GO:1990000) |
| 0.0 | 0.1 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 0.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.2 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.4 | 10.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.4 | 3.9 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 1.8 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 7.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 5.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 2.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.2 | 2.0 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 3.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 0.3 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.1 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 1.4 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 0.7 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.1 | 0.3 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 7.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.0 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 2.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 8.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 0.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.4 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 5.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.4 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 2.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 4.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 1.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 5.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 0.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 1.4 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 3.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 5.7 | GO:0000785 | chromatin(GO:0000785) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.7 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.8 | 5.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.8 | 10.1 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.5 | 7.7 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.3 | 3.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 1.8 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 4.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 2.3 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.2 | 2.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 1.6 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 3.8 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 1.3 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 5.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 0.7 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 3.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 2.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 3.2 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 0.6 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.1 | 0.2 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 0.3 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 0.7 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 1.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.0 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 6.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.4 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 3.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.4 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 1.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 4.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 2.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.2 | 8.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 8.2 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 2.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 5.0 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 1.6 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 8.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.6 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.8 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.1 | PID_ALK2_PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.4 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.5 | 1.6 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.4 | 4.4 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 4.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 8.0 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.2 | 9.7 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 3.9 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 4.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.3 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 3.7 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.3 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.2 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 3.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.5 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
