Motif ID: Rxrb

Z-value: 0.700


Transcription factors associated with Rxrb:

Gene SymbolEntrez IDGene Name
Rxrb ENSMUSG00000039656.10 Rxrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrbmm10_v2_chr17_+_34032348_340324010.123.7e-01Click!


Activity profile for motif Rxrb.

activity profile for motif Rxrb


Sorted Z-values histogram for motif Rxrb

Sorted Z-values for motif Rxrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxrb

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_118052235 10.108 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_+_93641041 8.017 ENSMUST00000020204.4
 Ntn4
netrin 4
chr4_-_117178726 7.984 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr1_+_6487231 5.744 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr4_+_44300876 5.658 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr6_-_23248264 5.609 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr18_+_57142782 5.522 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr10_-_88146867 5.346 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr5_+_110839973 4.433 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr11_-_40733373 4.328 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr1_-_170306332 4.256 ENSMUST00000179801.1
 Gm7694
predicted gene 7694
chr6_+_113531675 3.757 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr1_+_74791516 3.663 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr1_+_146420434 3.573 ENSMUST00000163646.1
 Gm5263
predicted gene 5263
chr1_+_84839833 3.510 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr4_+_136143497 3.235 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chrX_-_23365044 3.234 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr17_-_35704000 3.032 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr12_-_98737405 2.962 ENSMUST00000170188.1
 Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr11_+_40733936 2.922 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 10.1 GO:0006570 tyrosine metabolic process(GO:0006570)
1.6 8.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.6 8.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 5.7 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.9 5.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.9 5.5 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.5 5.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.4 5.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.1 4.4 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.0 3.9 GO:0051028 mRNA transport(GO:0051028)
0.5 3.8 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 3.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 3.7 GO:0001675 acrosome assembly(GO:0001675)
0.1 3.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.3 3.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 2.8 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.3 2.6 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.4 2.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 2.2 GO:0000338 protein deneddylation(GO:0000338)
0.1 2.2 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 8.3 GO:0032993 protein-DNA complex(GO:0032993)
0.2 7.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 7.1 GO:0005604 basement membrane(GO:0005604)
0.0 5.7 GO:0005938 cell cortex(GO:0005938)
0.0 5.7 GO:0000785 chromatin(GO:0000785)
0.2 5.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 5.5 GO:0000776 kinetochore(GO:0000776)
0.0 4.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.4 GO:0000781 chromosome, telomeric region(GO:0000781)
0.4 3.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 3.8 GO:0000793 condensed chromosome(GO:0000793)
0.2 3.7 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.8 GO:0005581 collagen trimer(GO:0005581)
0.2 2.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.0 GO:0005916 fascia adherens(GO:0005916)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
1.1 9.7 GO:0043237 laminin-1 binding(GO:0043237)
0.5 7.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 6.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.8 5.5 GO:0001849 complement component C1q binding(GO:0001849)
0.0 4.7 GO:0001047 core promoter binding(GO:0001047)
0.3 4.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 3.7 GO:0005109 frizzled binding(GO:0005109)
0.1 3.2 GO:0005504 fatty acid binding(GO:0005504)
0.3 3.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 3.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.3 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.2 2.0 GO:0002162 dystroglycan binding(GO:0002162)
0.3 1.8 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 8.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 8.2 PID_ATM_PATHWAY ATM pathway
0.2 8.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 5.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 8.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.6 4.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 4.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 4.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 1.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle