Motif ID: Scrt1

Z-value: 1.726


Transcription factors associated with Scrt1:

Gene SymbolEntrez IDGene Name
Scrt1 ENSMUSG00000048385.8 Scrt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt1mm10_v2_chr15_-_76521902_76522129-0.567.2e-06Click!


Activity profile for motif Scrt1.

activity profile for motif Scrt1


Sorted Z-values histogram for motif Scrt1

Sorted Z-values for motif Scrt1



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_34649987 23.555 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr7_-_30973367 21.495 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr15_-_98004634 19.867 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr5_+_33658567 17.477 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr7_-_30973399 16.891 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr2_+_131234043 16.788 ENSMUST00000041362.5
ENSMUST00000110199.2
 Mavs

mitochondrial antiviral signaling protein

chr11_+_115163333 16.302 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr6_+_128375456 16.131 ENSMUST00000100926.2
 4933413G19Rik
RIKEN cDNA 4933413G19 gene
chr17_-_25570678 15.733 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr7_-_30973464 15.024 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr9_-_27155418 14.977 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr5_+_33658550 14.762 ENSMUST00000152847.1
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr7_+_110221697 14.661 ENSMUST00000033325.7
 Swap70
SWA-70 protein
chr7_-_144939823 13.841 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr13_-_81633119 13.350 ENSMUST00000126444.1
ENSMUST00000128585.1
ENSMUST00000146749.1
ENSMUST00000095585.4
 Gpr98



G protein-coupled receptor 98



chr12_-_91779129 13.327 ENSMUST00000170077.1
 Ston2
stonin 2
chr5_+_33658123 13.076 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr11_-_100355383 12.414 ENSMUST00000146878.2
 Hap1
huntingtin-associated protein 1
chr10_+_56377300 11.604 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr8_+_31187317 11.478 ENSMUST00000066173.5
ENSMUST00000161788.1
ENSMUST00000110527.2
ENSMUST00000161502.1
 Fut10



fucosyltransferase 10




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
17.8 53.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.7 46.5 GO:0030953 astral microtubule organization(GO:0030953)
3.8 30.1 GO:0048852 diencephalon morphogenesis(GO:0048852)
1.7 19.9 GO:0060272 limb bud formation(GO:0060174) embryonic skeletal joint morphogenesis(GO:0060272)
0.6 17.9 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
5.6 16.8 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
5.4 16.3 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
5.2 15.7 GO:0072034 renal vesicle induction(GO:0072034)
1.7 15.0 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
2.9 14.7 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
1.5 14.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.0 13.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 12.5 GO:0006342 chromatin silencing(GO:0006342)
2.5 12.4 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.0 12.3 GO:0008380 RNA splicing(GO:0008380)
3.9 11.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 11.1 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.8 10.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
2.4 9.7 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.2 9.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.9 53.4 GO:0061689 tricellular tight junction(GO:0061689)
0.1 48.1 GO:0005813 centrosome(GO:0005813)
0.2 45.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.3 26.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
1.7 19.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 17.0 GO:0005814 centriole(GO:0005814)
1.5 16.3 GO:0032426 stereocilium tip(GO:0032426)
3.0 15.0 GO:0033010 paranodal junction(GO:0033010)
0.1 14.9 GO:0005884 actin filament(GO:0005884)
0.2 14.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 13.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 11.8 GO:0055037 recycling endosome(GO:0055037)
1.1 11.6 GO:0005916 fascia adherens(GO:0005916)
0.1 11.2 GO:0005681 spliceosomal complex(GO:0005681)
2.8 11.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 10.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.3 10.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 9.5 GO:0005871 kinesin complex(GO:0005871)
0.0 9.3 GO:0016607 nuclear speck(GO:0016607)
0.2 8.3 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 55.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
1.2 22.4 GO:0035198 miRNA binding(GO:0035198)
4.0 19.9 GO:0042289 MHC class II protein binding(GO:0042289)
3.4 16.8 GO:0050700 CARD domain binding(GO:0050700)
1.3 16.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 14.8 GO:0003924 GTPase activity(GO:0003924)
0.5 13.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 12.8 GO:0019904 protein domain specific binding(GO:0019904)
0.1 12.5 GO:0005178 integrin binding(GO:0005178)
1.6 12.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
2.4 12.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 12.1 GO:0045296 cadherin binding(GO:0045296)
0.0 11.9 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
2.9 11.6 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 11.6 GO:0031072 heat shock protein binding(GO:0031072)
2.9 11.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 11.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 11.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 10.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.7 10.4 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 42.6 PID_AURORA_A_PATHWAY Aurora A signaling
1.2 22.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.6 20.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 19.7 NABA_COLLAGENS Genes encoding collagen proteins
0.3 16.3 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
1.1 15.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 14.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 11.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 10.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 9.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 9.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 8.6 PID_FGF_PATHWAY FGF signaling pathway
0.2 7.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 6.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 6.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 3.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 41.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.0 21.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.1 18.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.6 15.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.4 12.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
1.0 11.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 9.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.9 9.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 8.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
1.1 8.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 6.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 6.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 6.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.7 5.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 5.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 4.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 4.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 4.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 4.1 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.6 3.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins