Motif ID: Sin3a

Z-value: 1.274


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57076395_570764110.542.5e-05Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_64340225 11.397 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr6_-_39206782 7.757 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr9_+_118478851 6.477 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_34372004 6.250 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chrX_+_69360294 5.982 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr18_-_72351009 5.161 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr4_+_107802277 4.945 ENSMUST00000106733.2
ENSMUST00000030356.3
ENSMUST00000106732.2
ENSMUST00000126573.1
 Lrp8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr18_-_72351029 4.901 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr3_-_52104891 4.895 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr6_+_34745952 4.631 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr12_-_64965496 4.484 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr1_-_119837613 4.460 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr6_-_38875923 4.415 ENSMUST00000162359.1
 Hipk2
homeodomain interacting protein kinase 2
chr6_+_34746368 4.220 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr2_-_104816696 3.960 ENSMUST00000117237.1
 Qser1
glutamine and serine rich 1
chr6_-_38875965 3.943 ENSMUST00000160360.1
 Hipk2
homeodomain interacting protein kinase 2
chr2_+_145167706 3.942 ENSMUST00000110007.1
 Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr1_-_119836999 3.872 ENSMUST00000163621.1
ENSMUST00000168303.1
 Ptpn4

protein tyrosine phosphatase, non-receptor type 4

chrX_-_147554050 3.696 ENSMUST00000112819.2
ENSMUST00000136789.1
 Lrch2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr19_+_59458372 3.692 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 516 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 13.5 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
1.0 11.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 10.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
2.9 8.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 7.6 GO:1990403 embryonic brain development(GO:1990403)
0.8 7.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 6.5 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.4 6.4 GO:0021542 dentate gyrus development(GO:0021542)
1.2 6.0 GO:0035063 nuclear speck organization(GO:0035063)
2.0 5.9 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 5.9 GO:0046548 retinal rod cell development(GO:0046548)
0.7 5.7 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.6 5.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.9 5.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.5 5.5 GO:0042118 endothelial cell activation(GO:0042118)
0.5 4.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 4.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 4.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 4.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.5 4.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.1 GO:0005814 centriole(GO:0005814)
0.1 11.0 GO:0016605 PML body(GO:0016605)
0.1 10.0 GO:0032993 protein-DNA complex(GO:0032993)
0.1 9.8 GO:0005923 bicellular tight junction(GO:0005923)
0.3 9.5 GO:0043194 axon initial segment(GO:0043194)
0.9 9.4 GO:0032584 growth cone membrane(GO:0032584)
1.0 9.3 GO:0030478 actin cap(GO:0030478)
0.0 9.2 GO:0016607 nuclear speck(GO:0016607)
0.2 8.2 GO:0030673 axolemma(GO:0030673)
0.4 7.8 GO:0097470 ribbon synapse(GO:0097470)
0.0 7.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.2 7.0 GO:0090544 BAF-type complex(GO:0090544)
0.1 6.8 GO:0072686 mitotic spindle(GO:0072686)
0.9 5.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.3 5.3 GO:0010369 chromocenter(GO:0010369)
0.0 5.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 5.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 4.9 GO:0072562 blood microparticle(GO:0072562)
0.1 4.6 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.7 11.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 11.2 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
1.4 11.0 GO:0046790 virion binding(GO:0046790)
1.8 10.7 GO:0005042 netrin receptor activity(GO:0005042)
0.0 10.7 GO:0008017 microtubule binding(GO:0008017)
0.8 9.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 8.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 7.7 GO:0070840 dynein complex binding(GO:0070840)
0.3 7.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.9 7.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 6.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.4 5.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 4.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 4.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 4.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 4.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.8 4.6 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 4.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 12.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 9.6 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 7.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 6.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 5.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 4.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 2.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 2.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 2.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 8.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 7.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 6.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.6 5.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.3 5.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 5.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 5.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 5.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 5.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.6 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 4.5 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 4.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 4.4 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 3.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 3.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 3.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation