Motif ID: Six3_Six1_Six2

Z-value: 0.895

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85620816_856208430.501.2e-04Click!
Six2mm10_v2_chr17_-_85688252_856882750.491.5e-04Click!
Six1mm10_v2_chr12_-_73047179_730471790.302.8e-02Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_139454747 13.642 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chrX_-_142966709 9.221 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_98422961 8.436 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr15_-_82244716 6.904 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr18_+_56432116 6.672 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr15_-_75894474 6.244 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr5_+_140607334 6.200 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_-_80115294 5.275 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr15_+_98571004 4.935 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr5_+_139423151 4.608 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr2_+_106693185 3.958 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr3_-_85722474 3.516 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr10_-_128180265 3.448 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr9_+_65141154 3.315 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr8_-_4275886 2.849 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr3_+_130068390 2.843 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr1_+_136467958 2.379 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chrX_+_169685191 2.278 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr9_+_72958785 2.133 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr3_-_37724321 2.105 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.6 GO:0051661 maintenance of centrosome location(GO:0051661)
2.1 8.4 GO:0006776 vitamin A metabolic process(GO:0006776)
1.2 6.2 GO:0007386 compartment pattern specification(GO:0007386)
1.8 5.3 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
1.2 4.6 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.2 2.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 2.6 GO:0051923 sulfation(GO:0051923)
0.0 2.6 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.8 2.4 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 2.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.3 2.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.2 2.1 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.7 2.0 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 1.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.5 1.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 1.4 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.3 1.2 GO:0060032 notochord regression(GO:0060032)
0.2 1.0 GO:0046208 spermine catabolic process(GO:0046208)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.6 GO:0036449 microtubule minus-end(GO:0036449)
0.1 9.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.9 GO:0000776 kinetochore(GO:0000776)
0.1 6.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 4.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 3.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.4 GO:0051233 spindle midzone(GO:0051233)
0.2 2.1 GO:0005688 U6 snRNP(GO:0005688)
0.1 2.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 1.9 GO:0061574 ASAP complex(GO:0061574)
0.0 1.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.5 GO:0036038 MKS complex(GO:0036038)
0.5 1.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.2 GO:0097542 ciliary tip(GO:0097542)
0.3 0.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.9 GO:0001741 XY body(GO:0001741)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 GO:0005516 calmodulin binding(GO:0005516)
1.4 8.4 GO:0019841 retinol binding(GO:0019841)
2.1 6.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.8 5.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.8 4.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.8 GO:0051087 chaperone binding(GO:0051087)
0.9 2.6 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 2.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 2.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 2.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 2.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 1.0 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.9 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.8 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 3.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 6.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 5.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 2.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.0 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins