Motif ID: Six4
Z-value: 0.537
Transcription factors associated with Six4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Six4 | ENSMUSG00000034460.8 | Six4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Six4 | mm10_v2_chr12_-_73113407_73113456 | 0.14 | 3.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.8 | 2.3 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 0.5 | 1.6 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.2 | 1.9 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 0.9 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.2 | 0.7 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.2 | 0.6 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.2 | 1.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.2 | 0.5 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
| 0.1 | 0.6 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.1 | 0.6 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.1 | 1.0 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.5 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.1 | 0.6 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.1 | 2.3 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.5 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.0 | 0.7 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 1.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 1.6 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 0.4 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 1.9 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 1.1 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.0 | 0.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.1 | 1.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 2.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 0.7 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 1.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 2.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.7 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.2 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 1.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.5 | 1.9 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.2 | 0.9 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 0.6 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
| 0.1 | 1.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.6 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.1 | 1.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 0.4 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.1 | 1.0 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.1 | 0.6 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 0.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 1.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 1.3 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.5 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.0 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.7 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 2.3 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 5.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.8 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 0.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.6 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 1.1 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 1.3 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.3 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.6 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.6 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.7 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
