Motif ID: Six4

Z-value: 0.537


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.143.2e-01Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Showing 1 to 20 of 60 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.194 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 2.351 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_+_7555053 2.320 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr17_+_35049966 2.316 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr13_+_51645232 1.914 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr7_-_143460989 1.883 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr13_+_54071815 1.643 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr14_-_103843685 1.570 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr8_+_62951361 1.424 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr1_-_78968079 1.373 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr7_+_29307924 1.348 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr6_+_50110186 1.347 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
 Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr7_+_29309429 1.341 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr11_+_67078293 1.289 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr6_+_134929118 1.241 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr6_+_134929089 1.143 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr3_+_40950631 1.097 ENSMUST00000048490.6
 Larp1b
La ribonucleoprotein domain family, member 1B
chr5_-_145191511 1.075 ENSMUST00000161845.1
 Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr4_-_134018829 1.026 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr13_-_9878998 0.944 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.8 2.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 2.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 1.9 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 1.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.5 1.6 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 1.6 GO:0006826 iron ion transport(GO:0006826)
0.2 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.1 GO:0006754 ATP biosynthetic process(GO:0006754)
0.1 1.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.9 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.9 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 0.7 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 0.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0071565 nBAF complex(GO:0071565)
0.1 2.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.3 GO:0032982 myosin filament(GO:0032982)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.7 GO:0001740 Barr body(GO:0001740)
0.0 0.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 0.6 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.3 GO:0005254 chloride channel activity(GO:0005254)
0.5 1.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 1.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 1.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 0.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.3 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 1.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha