Motif ID: Six6

Z-value: 0.454


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.019.6e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 3.292 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr5_+_140607334 3.237 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_+_98422961 2.327 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr11_+_98412461 2.177 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr6_-_23248264 2.113 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_139454747 1.816 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr4_-_97584605 1.682 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.631 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_142966709 1.574 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr14_+_67234620 1.473 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr15_-_82244716 1.461 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr16_+_84774123 1.228 ENSMUST00000114195.1
 Jam2
junction adhesion molecule 2
chr4_+_156013835 1.142 ENSMUST00000030952.5
 Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr8_-_94918012 1.098 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr10_+_24595623 1.050 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr3_+_88207308 1.039 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr4_-_43653542 1.036 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr18_+_56432116 0.914 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr4_-_43653560 0.913 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chrX_+_103414461 0.879 ENSMUST00000033691.4
 Tsx
testis specific X-linked gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 3.2 GO:0007386 compartment pattern specification(GO:0007386)
0.6 2.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.7 2.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.4 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.9 GO:0007338 single fertilization(GO:0007338)
0.4 1.8 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.3 1.3 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 1.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 1.1 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 1.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 0.9 GO:0060032 notochord regression(GO:0060032)
0.0 0.9 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.3 0.8 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 0.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.7 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.1 2.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 2.2 GO:0043219 lateral loop(GO:0043219)
0.4 1.8 GO:0036449 microtubule minus-end(GO:0036449)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0097542 ciliary tip(GO:0097542)
0.0 0.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.8 GO:0001741 XY body(GO:0001741)
0.1 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.7 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 0.5 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.1 3.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.3 GO:0019841 retinol binding(GO:0019841)
0.7 2.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 1.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.7 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.7 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0003774 motor activity(GO:0003774)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.5 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 3.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.6 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.9 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters