Motif ID: Smad1

Z-value: 1.263


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.133.6e-01Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 10.181 ENSMUST00000075312.3
 Ttr
transthyretin
chrX_+_73483602 8.454 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr15_-_66812593 5.667 ENSMUST00000100572.3
 Sla
src-like adaptor
chr1_-_171234290 4.252 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr2_-_152951547 4.249 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr2_-_25470031 4.196 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr12_-_24680890 3.371 ENSMUST00000156453.2
 Cys1
cystin 1
chr4_-_133498538 3.227 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr6_+_55336424 2.887 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr8_+_104101625 2.863 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr6_+_121300227 2.827 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr19_-_57118981 2.825 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr2_-_93452679 2.790 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr5_-_139129662 2.700 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_+_17087934 2.612 ENSMUST00000152671.1
 Psg16
pregnancy specific glycoprotein 16
chr10_-_81025406 2.601 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr18_-_66860458 2.508 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr10_+_79988584 2.501 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr11_+_32296489 2.493 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr9_+_112234257 2.444 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 727 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 11.2 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 9.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 9.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 7.3 GO:0007416 synapse assembly(GO:0007416)
0.1 6.5 GO:0034605 cellular response to heat(GO:0034605)
1.1 5.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.8 5.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 4.8 GO:0015992 proton transport(GO:0015992)
0.4 4.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 4.4 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 4.2 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.5 3.8 GO:0015862 uridine transport(GO:0015862)
0.2 3.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.7 3.5 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.1 3.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.1 3.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.5 3.2 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 3.1 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.5 3.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 3.0 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 304 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 58.9 GO:0031224 intrinsic component of membrane(GO:0031224)
0.1 14.0 GO:0030133 transport vesicle(GO:0030133)
0.1 13.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 10.0 GO:0005615 extracellular space(GO:0005615)
0.1 8.3 GO:0072562 blood microparticle(GO:0072562)
0.1 8.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 7.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 7.2 GO:0009986 cell surface(GO:0009986)
1.8 7.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 6.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 6.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 5.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 4.6 GO:0031526 brush border membrane(GO:0031526)
0.0 4.2 GO:0019866 organelle inner membrane(GO:0019866)
1.0 3.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.5 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 427 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 12.5 GO:0003924 GTPase activity(GO:0003924)
1.1 9.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 9.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 9.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 7.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.2 7.5 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
1.8 7.0 GO:0031720 haptoglobin binding(GO:0031720)
0.1 6.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.3 5.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 5.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 4.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 4.4 GO:0017080 sodium channel regulator activity(GO:0017080)
1.0 4.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 4.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.3 3.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 3.8 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 3.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 3.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 12.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 9.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 8.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 4.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.3 PID_ALK1_PATHWAY ALK1 signaling events
0.2 3.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 2.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.8 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 2.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.0 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 1.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.2 1.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 12.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.5 11.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.6 8.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 7.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 7.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 6.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 5.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 4.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 4.0 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 4.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 4.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 3.9 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 3.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 3.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 3.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules