Motif ID: Smad2

Z-value: 0.533


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.601.4e-06Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_42583628 4.244 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr6_-_6882068 3.828 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr9_-_119578981 3.583 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr19_+_59458372 3.497 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr4_+_11191726 3.438 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr3_+_127633134 3.430 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr7_-_116237767 3.366 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr15_+_57694651 3.079 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr8_-_87959560 2.699 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_+_83137089 2.695 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr17_-_35700520 2.213 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr13_-_78199757 2.142 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr16_+_64851991 2.016 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr4_+_11191354 1.963 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr13_+_23752267 1.719 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chrX_-_94123359 1.601 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr10_-_49788743 1.550 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr1_-_172297989 1.438 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr7_+_82867327 1.429 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr8_-_105637403 1.383 ENSMUST00000182046.1
 Gm5914
predicted gene 5914

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 5.4 GO:0007129 synapsis(GO:0007129)
0.8 4.2 GO:0021764 amygdala development(GO:0021764)
1.3 3.8 GO:0060166 olfactory pit development(GO:0060166)
1.2 3.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.6 3.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 3.4 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 3.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 2.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 2.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.5 GO:0048599 oocyte development(GO:0048599)
0.5 1.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.2 1.4 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 1.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.2 1.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.2 GO:1903012 positive regulation of bone development(GO:1903012)
0.1 1.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 3.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 3.4 GO:0005915 zonula adherens(GO:0005915)
0.1 1.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 1.6 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 1.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 1.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.1 GO:0043218 compact myelin(GO:0043218)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 4.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.8 GO:0071837 HMG box domain binding(GO:0071837)
0.5 3.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 3.4 GO:0070097 delta-catenin binding(GO:0070097)
0.1 3.4 GO:0070888 E-box binding(GO:0070888)
0.0 3.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 2.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 2.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.4 GO:1990239 steroid hormone binding(GO:1990239)
0.1 1.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.1 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 0.7 GO:0001727 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 3.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 1.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.9 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes