Motif ID: Smad3

Z-value: 0.668


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_637579940.463.9e-04Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_53707532 9.518 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr13_+_23533869 4.856 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_21832194 4.808 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr18_-_74207771 4.699 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr13_-_21750505 4.378 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr13_-_23551648 4.102 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr13_+_23531044 3.940 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr14_-_62456286 3.871 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr13_+_23581563 3.556 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr18_-_77047243 3.393 ENSMUST00000137354.1
ENSMUST00000137498.1
 Katnal2

katanin p60 subunit A-like 2

chr6_-_72235559 3.189 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_+_92354783 2.972 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase
chr13_-_22042949 2.801 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr7_+_51880312 2.799 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr13_-_21833575 2.690 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_+_22043189 2.591 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr18_-_77047282 2.558 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
 Katnal2



katanin p60 subunit A-like 2



chr9_-_66514567 2.513 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr13_+_21735055 2.448 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_-_23571151 2.314 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 23.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 14.0 GO:0006342 chromatin silencing(GO:0006342)
3.2 9.5 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 4.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 4.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.3 4.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 3.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 3.5 GO:0007050 cell cycle arrest(GO:0007050)
0.2 3.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.7 3.0 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.2 2.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 2.3 GO:0035082 axoneme assembly(GO:0035082)
0.5 1.5 GO:0002314 germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) xanthine metabolic process(GO:0046110) purine deoxyribonucleoside metabolic process(GO:0046122) regulation of adenosine receptor signaling pathway(GO:0060167)
0.0 1.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 1.4 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.4 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.1 1.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.4 1.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 1.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.2 0.8 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 15.6 GO:0000786 nucleosome(GO:0000786)
0.0 7.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 6.5 GO:0043195 terminal bouton(GO:0043195)
0.0 4.9 GO:0005874 microtubule(GO:0005874)
0.4 4.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 3.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 2.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.8 GO:0044306 neuron projection terminus(GO:0044306)
0.1 1.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.4 1.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 0.8 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.8 GO:0030018 Z disc(GO:0030018)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.7 GO:0042393 histone binding(GO:0042393)
0.2 9.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.9 6.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 3.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
1.0 3.0 GO:0051870 methotrexate binding(GO:0051870)
0.4 2.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.5 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 1.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.3 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 29.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 9.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 3.0 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 2.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.5 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway