Motif ID: Smad4

Z-value: 1.434


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.162.4e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_42583628 19.523 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr12_+_103314944 18.377 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr2_+_70562854 15.467 ENSMUST00000130998.1
 Gad1
glutamate decarboxylase 1
chr2_+_70563435 14.827 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr14_-_54577578 14.608 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr4_-_117178726 14.059 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr7_+_45216671 13.865 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr18_+_57133065 13.629 ENSMUST00000075770.6
 Megf10
multiple EGF-like-domains 10
chr14_+_50944499 13.272 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr10_-_127534540 13.135 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr7_+_45215753 11.575 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr19_-_40271506 9.847 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)
chr17_-_70851710 9.782 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_5740885 9.700 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_-_21832194 9.178 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr17_+_75178797 8.713 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr7_-_70360593 8.649 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr5_+_92683625 8.544 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr10_-_92164666 8.148 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr17_+_75178911 8.013 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 31.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
4.3 30.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.1 25.4 GO:0048368 lateral mesoderm development(GO:0048368)
3.9 19.5 GO:0021764 amygdala development(GO:0021764)
0.7 16.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
2.5 15.3 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
2.1 14.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
2.8 14.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.5 13.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
4.4 13.3 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.3 11.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
2.5 10.1 GO:0015889 cobalamin transport(GO:0015889)
0.8 9.8 GO:0038092 nodal signaling pathway(GO:0038092)
3.2 9.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.6 8.9 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
1.7 8.6 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 8.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
2.0 8.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 7.4 GO:0021954 central nervous system neuron development(GO:0021954)
0.3 6.6 GO:0050434 positive regulation of viral transcription(GO:0050434)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.5 25.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.6 24.2 GO:0060077 inhibitory synapse(GO:0060077)
0.7 22.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 18.8 GO:0005874 microtubule(GO:0005874)
0.0 17.4 GO:0005667 transcription factor complex(GO:0005667)
5.6 16.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 14.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 13.4 GO:0001891 phagocytic cup(GO:0001891)
0.3 12.3 GO:0035371 microtubule plus-end(GO:0035371)
0.3 12.0 GO:0000786 nucleosome(GO:0000786)
0.4 9.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.8 8.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 8.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 8.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 7.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 6.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 5.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.8 GO:0016604 nuclear body(GO:0016604)
0.0 5.7 GO:0001650 fibrillar center(GO:0001650)
0.9 5.2 GO:0035976 AP1 complex(GO:0035976)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.5 GO:0042393 histone binding(GO:0042393)
4.3 30.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.3 25.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 19.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
4.4 17.7 GO:0050436 microfibril binding(GO:0050436)
1.1 14.6 GO:0045294 alpha-catenin binding(GO:0045294)
1.1 14.2 GO:0001972 retinoic acid binding(GO:0001972)
1.9 13.6 GO:0001849 complement component C1q binding(GO:0001849)
4.4 13.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 13.0 GO:0005096 GTPase activator activity(GO:0005096)
0.7 12.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 11.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 11.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.4 10.1 GO:0031419 cobalamin binding(GO:0031419)
0.6 9.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 9.8 GO:0070410 co-SMAD binding(GO:0070410)
0.4 9.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 9.4 GO:0070888 E-box binding(GO:0070888)
0.3 9.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 7.9 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 14.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 11.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 9.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 9.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 8.0 PID_BMP_PATHWAY BMP receptor signaling
0.3 7.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 6.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 6.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.3 6.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 5.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 5.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 4.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.8 NABA_COLLAGENS Genes encoding collagen proteins
0.2 4.5 PID_ALK1_PATHWAY ALK1 signaling events
0.1 4.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.5 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 2.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 31.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.0 31.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.3 30.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.8 29.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.5 14.1 REACTOME_KINESINS Genes involved in Kinesins
1.2 13.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.3 9.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 8.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 8.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 8.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 6.2 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.4 5.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 5.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 5.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 4.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 4.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.1 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2 2.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions