Motif ID: Smarcc1_Fosl1

Z-value: 1.251

Transcription factors associated with Smarcc1_Fosl1:

Gene SymbolEntrez IDGene Name
Fosl1 ENSMUSG00000024912.5 Fosl1
Smarcc1 ENSMUSG00000032481.10 Smarcc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl1mm10_v2_chr19_+_5447692_54477110.774.5e-12Click!
Smarcc1mm10_v2_chr9_+_110132015_110132102-0.393.0e-03Click!


Activity profile for motif Smarcc1_Fosl1.

activity profile for motif Smarcc1_Fosl1


Sorted Z-values histogram for motif Smarcc1_Fosl1

Sorted Z-values for motif Smarcc1_Fosl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smarcc1_Fosl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 13.548 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr9_-_20728219 10.755 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr6_+_17463927 9.740 ENSMUST00000115442.1
 Met
met proto-oncogene
chr2_+_156475803 8.922 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_156475844 8.861 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr3_+_55461758 7.791 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr4_+_42091207 7.720 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr15_-_33687840 7.557 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr15_-_66812593 7.454 ENSMUST00000100572.3
 Sla
src-like adaptor
chr10_+_86779000 6.909 ENSMUST00000099396.2
 Nt5dc3
5'-nucleotidase domain containing 3
chr9_+_60712989 6.713 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr16_+_17144600 6.711 ENSMUST00000115702.1
 Ydjc
YdjC homolog (bacterial)
chr6_-_124769548 6.453 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr10_-_64090241 6.366 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_-_54611332 6.347 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611274 6.320 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr3_+_109573907 6.194 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr9_-_112187766 6.023 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_-_59076069 5.994 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr16_-_17144415 5.986 ENSMUST00000115709.1
 Ccdc116
coiled-coil domain containing 116

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 480 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.7 GO:0034605 cellular response to heat(GO:0034605)
0.1 16.7 GO:0061025 membrane fusion(GO:0061025)
1.0 14.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
2.1 14.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 12.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 12.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 12.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
2.1 10.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.7 8.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 8.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
1.4 8.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.2 8.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 7.9 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 7.8 GO:0048821 erythrocyte development(GO:0048821)
0.6 7.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
2.4 7.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
1.8 7.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
1.2 6.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.0 6.2 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.3 6.0 GO:0006622 protein targeting to lysosome(GO:0006622)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 50.2 GO:0016021 integral component of membrane(GO:0016021)
0.1 30.4 GO:0097060 synaptic membrane(GO:0097060)
0.2 17.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 16.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 15.6 GO:0060076 excitatory synapse(GO:0060076)
0.1 14.0 GO:0055037 recycling endosome(GO:0055037)
1.2 13.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 13.0 GO:0042734 presynaptic membrane(GO:0042734)
0.3 12.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 11.4 GO:0005604 basement membrane(GO:0005604)
0.1 11.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 11.0 GO:0009925 basal plasma membrane(GO:0009925)
0.1 10.4 GO:0005581 collagen trimer(GO:0005581)
1.5 10.3 GO:0005638 lamin filament(GO:0005638)
0.5 9.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 8.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 8.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.3 7.9 GO:0071565 nBAF complex(GO:0071565)
0.4 7.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 6.6 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 299 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 18.6 GO:0005096 GTPase activator activity(GO:0005096)
3.7 14.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 14.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.1 13.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 13.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 11.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.7 11.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 11.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 11.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 10.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.3 10.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 9.9 GO:0015485 cholesterol binding(GO:0015485)
0.3 9.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 9.2 GO:0005516 calmodulin binding(GO:0005516)
0.4 8.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 8.4 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 7.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 7.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 7.0 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 16.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 14.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.5 14.2 PID_ARF_3PATHWAY Arf1 pathway
0.1 9.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.9 9.4 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.2 8.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 7.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 6.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 6.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.2 5.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 5.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 5.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 4.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 4.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 3.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 3.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 3.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.4 15.4 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.7 14.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.4 12.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 11.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 11.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 10.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.6 8.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.3 8.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 8.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 7.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 7.8 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.3 7.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 6.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 6.3 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.2 5.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.4 5.8 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.4 5.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 5.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 5.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism