Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.055

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.696.4e-09Click!
Snai1mm10_v2_chr2_+_167538192_1675382100.162.4e-01Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.104.9e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_82616885 27.174 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr11_-_67922136 26.463 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr6_+_114131229 20.260 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr15_-_66831625 19.969 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 18.941 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr18_-_61911783 18.872 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr4_+_85205417 17.824 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr1_-_134234492 16.541 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr8_+_70493156 15.513 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr19_-_57314896 14.619 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr17_-_26201363 13.825 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr14_+_101729907 13.367 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr7_-_27446599 13.274 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr2_-_32312162 12.992 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr16_+_18776839 12.708 ENSMUST00000043577.1
 Cldn5
claudin 5
chr11_+_103171081 12.700 ENSMUST00000042286.5
 Fmnl1
formin-like 1
chr5_-_139130159 12.634 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_147076482 12.184 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr13_+_83504032 11.951 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_+_54571358 11.726 ENSMUST00000025356.2
 Mal2
mal, T cell differentiation protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 968 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 31.7 GO:0030032 lamellipodium assembly(GO:0030032)
1.3 31.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
4.1 28.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
3.8 26.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
4.2 24.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
2.7 24.3 GO:0071420 cellular response to histamine(GO:0071420)
7.8 23.5 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.9 23.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 23.1 GO:0008333 endosome to lysosome transport(GO:0008333)
0.5 22.0 GO:0034605 cellular response to heat(GO:0034605)
0.9 20.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 19.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
1.8 17.8 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.8 16.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 15.9 GO:0016579 protein deubiquitination(GO:0016579)
0.6 15.7 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
5.2 15.5 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
3.9 15.5 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.1 15.1 GO:0001553 luteinization(GO:0001553)
0.5 14.9 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 326 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 79.6 GO:0031224 intrinsic component of membrane(GO:0031224)
0.4 75.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 46.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.5 42.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.0 37.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 37.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 35.4 GO:0005769 early endosome(GO:0005769)
1.2 34.3 GO:0033268 node of Ranvier(GO:0033268)
0.3 32.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.5 31.0 GO:0032279 asymmetric synapse(GO:0032279)
1.5 29.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 28.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.9 28.0 GO:1902711 GABA-A receptor complex(GO:1902711)
1.2 27.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
4.5 27.1 GO:0008091 spectrin(GO:0008091)
0.3 26.6 GO:0005795 Golgi stack(GO:0005795)
0.1 24.6 GO:0000139 Golgi membrane(GO:0000139)
0.6 24.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.9 24.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
7.7 23.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 534 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 39.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
5.0 34.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 34.4 GO:0005096 GTPase activator activity(GO:0005096)
2.6 30.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.5 28.9 GO:0030507 spectrin binding(GO:0030507)
2.3 25.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.1 24.6 GO:0030506 ankyrin binding(GO:0030506)
3.4 23.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
3.3 23.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.6 22.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.7 22.2 GO:0030552 cAMP binding(GO:0030552)
0.6 21.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 20.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.0 20.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 20.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 18.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
6.2 18.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.7 18.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.6 18.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 18.5 GO:0005158 insulin receptor binding(GO:0005158)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 70.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 53.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 31.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.6 29.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 26.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 26.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 24.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 24.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.6 20.0 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
1.2 19.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 19.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 17.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 16.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 12.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.5 11.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.3 11.0 PID_INSULIN_PATHWAY Insulin Pathway
0.4 10.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.4 10.0 PID_ARF_3PATHWAY Arf1 pathway
0.3 9.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.3 8.7 SIG_CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 45.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.3 45.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.8 40.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.4 37.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.9 32.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 28.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.7 27.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.8 26.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.5 22.8 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases
1.7 22.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.6 21.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.5 20.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 19.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
3.1 18.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.5 18.3 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.7 17.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.7 14.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.7 14.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.4 13.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.0 12.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)