Motif ID: Sox1

Z-value: 0.294


Transcription factors associated with Sox1:

Gene SymbolEntrez IDGene Name
Sox1 ENSMUSG00000096014.1 Sox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox1mm10_v2_chr8_+_12395287_12395295-0.239.5e-02Click!


Activity profile for motif Sox1.

activity profile for motif Sox1


Sorted Z-values histogram for motif Sox1

Sorted Z-values for motif Sox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_57509995 1.117 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr15_-_75048837 1.101 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr11_+_104282371 0.831 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr4_-_120747248 0.733 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr17_-_47692466 0.721 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chrX_+_74297097 0.646 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
 Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr15_-_74997634 0.635 ENSMUST00000023248.6
 Ly6a
lymphocyte antigen 6 complex, locus A
chr6_+_117841174 0.520 ENSMUST00000112859.1
ENSMUST00000137224.1
ENSMUST00000164472.1
ENSMUST00000112861.1
ENSMUST00000035638.8
 Zfp637




zinc finger protein 637




chr8_+_13159135 0.424 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr6_+_114648811 0.413 ENSMUST00000182510.1
 Atg7
autophagy related 7
chr18_+_37496997 0.356 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr11_-_68853119 0.342 ENSMUST00000018880.7
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr7_+_119690026 0.341 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chr17_+_34263209 0.326 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr11_-_68853019 0.325 ENSMUST00000108672.1
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr16_-_37654408 0.305 ENSMUST00000023514.3
 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr17_-_34287770 0.275 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chr7_+_80343091 0.268 ENSMUST00000032747.5
 Hddc3
HD domain containing 3
chr1_-_195131536 0.256 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr6_+_121183667 0.228 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
 Pex26



peroxisomal biogenesis factor 26



chr9_-_108305941 0.189 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr15_-_76918010 0.165 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr7_-_46919915 0.137 ENSMUST00000143413.1
ENSMUST00000014546.8
 Tsg101

tumor susceptibility gene 101

chr2_-_84650714 0.117 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr3_-_34005490 0.111 ENSMUST00000060997.2
 Gm9791
predicted pseudogene 9791
chr2_-_84650760 0.108 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr17_+_34969912 0.101 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr5_+_21737141 0.095 ENSMUST00000030882.5
 Pmpcb
peptidase (mitochondrial processing) beta
chr8_+_83165348 0.070 ENSMUST00000034145.4
 Tbc1d9
TBC1 domain family, member 9
chr5_-_13121766 0.070 ENSMUST00000078246.4
 Gm10108
predicted pseudogene 10108
chr2_-_34755229 0.066 ENSMUST00000102800.1
 Gapvd1
GTPase activating protein and VPS9 domains 1
chr14_-_30923547 0.055 ENSMUST00000170415.1
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr2_+_34406845 0.032 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr4_+_136357423 0.029 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr9_-_114390633 0.027 ENSMUST00000084881.4
 Crtap
cartilage associated protein
chr5_+_21186267 0.013 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 0.7 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 0.4 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.4 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.1 0.8 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 0.7 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1 0.3 GO:0002339 B cell selection(GO:0002339)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.2 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.0 1.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.2 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.7 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.8 GO:0045298 tubulin complex(GO:0045298)
0.1 1.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.4 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.3 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 1.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0042605 peptide antigen binding(GO:0042605)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins