Motif ID: Sox11

Z-value: 0.442


Transcription factors associated with Sox11:

Gene SymbolEntrez IDGene Name
Sox11 ENSMUSG00000063632.5 Sox11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_273427260.656.6e-08Click!


Activity profile for motif Sox11.

activity profile for motif Sox11


Sorted Z-values histogram for motif Sox11

Sorted Z-values for motif Sox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16378231 1.938 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr6_-_23248264 1.622 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_50330987 1.214 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr2_+_154548888 1.174 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr14_-_47418407 1.127 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr9_+_65890237 1.114 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr2_-_79456750 1.016 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr4_-_97584612 0.908 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 0.906 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_82233112 0.891 ENSMUST00000023262.5
 Gm9747
predicted gene 9747
chr5_+_64812336 0.863 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr5_+_14514918 0.819 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr5_-_131616599 0.792 ENSMUST00000161804.1
 Auts2
autism susceptibility candidate 2
chr13_-_99516537 0.729 ENSMUST00000064762.4
 Map1b
microtubule-associated protein 1B
chr2_+_15055274 0.698 ENSMUST00000069870.3
 Arl5b
ADP-ribosylation factor-like 5B
chr7_+_70388305 0.697 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr7_+_83631959 0.632 ENSMUST00000075418.7
ENSMUST00000117410.1
 Stard5

StAR-related lipid transfer (START) domain containing 5

chr9_+_52047150 0.624 ENSMUST00000163153.1
 Rdx
radixin
chr16_+_8830093 0.621 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr14_-_52213379 0.615 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr11_-_64436653 0.615 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr11_+_69364010 0.588 ENSMUST00000166700.1
 Gm17305
predicted gene, 17305
chr8_-_34965631 0.561 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr16_-_44558864 0.541 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr17_-_29007925 0.497 ENSMUST00000009138.5
ENSMUST00000119274.1
 Stk38

serine/threonine kinase 38

chr11_-_50292302 0.486 ENSMUST00000059458.4
 Maml1
mastermind like 1 (Drosophila)
chr15_+_76797628 0.486 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr6_-_42693087 0.471 ENSMUST00000121083.1
 Fam115a
family with sequence similarity 115, member A
chr6_-_42693030 0.466 ENSMUST00000045140.4
 Fam115a
family with sequence similarity 115, member A
chr7_-_73541738 0.445 ENSMUST00000169922.2
 Chd2
chromodomain helicase DNA binding protein 2
chr16_-_44558879 0.423 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr1_+_44119952 0.413 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing
chr10_+_17796256 0.379 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr7_-_55962466 0.377 ENSMUST00000032635.7
ENSMUST00000152649.1
 Nipa2

non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

chr5_-_148552783 0.366 ENSMUST00000079324.7
ENSMUST00000164904.1
 Ubl3

ubiquitin-like 3

chr9_+_107888129 0.357 ENSMUST00000035202.2
 Mon1a
MON1 homolog A (yeast)
chr10_-_76110956 0.340 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr17_+_43016536 0.323 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr19_-_46969474 0.320 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr5_+_121795034 0.319 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr10_+_119992916 0.319 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr3_+_67430096 0.314 ENSMUST00000077271.6
ENSMUST00000161009.1
 Gfm1

G elongation factor, mitochondrial 1

chr11_+_4873951 0.304 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr3_+_60877002 0.302 ENSMUST00000099086.2
 Gm8325
predicted pseudogene 8325
chr2_-_36136602 0.300 ENSMUST00000122456.1
 Rbm18
RNA binding motif protein 18
chr4_-_44072578 0.274 ENSMUST00000173383.1
 Gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr6_-_12109583 0.265 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr2_-_36136773 0.255 ENSMUST00000028251.3
 Rbm18
RNA binding motif protein 18
chr10_+_24869982 0.254 ENSMUST00000092646.6
 Med23
mediator complex subunit 23
chrX_-_37104523 0.245 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_+_101074727 0.238 ENSMUST00000085177.3
 Msl2
male-specific lethal 2 homolog (Drosophila)
chr2_-_156111954 0.234 ENSMUST00000142960.2
ENSMUST00000136296.2
ENSMUST00000059647.5
ENSMUST00000109604.2
ENSMUST00000138068.1
ENSMUST00000128499.1
 Cpne1

Rbm12



copine I

RNA binding motif protein 12



chr2_+_3114220 0.228 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr16_-_38341812 0.205 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr15_-_81104999 0.200 ENSMUST00000109579.2
 Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr12_-_54862783 0.198 ENSMUST00000078124.7
 Cfl2
cofilin 2, muscle
chr7_-_105737376 0.190 ENSMUST00000098148.4
 Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr13_+_40859768 0.132 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_-_45503282 0.121 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_+_134236483 0.112 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr10_+_115569986 0.099 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr2_-_127247620 0.093 ENSMUST00000174030.1
ENSMUST00000174863.1
 Ciao1

cytosolic iron-sulfur protein assembly 1

chrX_+_166344692 0.077 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr2_-_86347764 0.070 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr11_+_24080664 0.063 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr5_+_145084100 0.058 ENSMUST00000124379.1
 Arpc1a
actin related protein 2/3 complex, subunit 1A
chr9_+_89909775 0.048 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr3_+_28805436 0.037 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr8_-_83442648 0.030 ENSMUST00000167525.1
 Scoc
short coiled-coil protein
chr2_-_127247768 0.017 ENSMUST00000003759.4
 Ciao1
cytosolic iron-sulfur protein assembly 1
chr10_+_121365078 0.017 ENSMUST00000040344.6
 Gns
glucosamine (N-acetyl)-6-sulfatase
chr5_+_144100387 0.005 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr11_-_106193511 0.003 ENSMUST00000007444.7
ENSMUST00000152008.1
ENSMUST00000103072.3
ENSMUST00000106867.1
 Strada



STE20-related kinase adaptor alpha



chr9_+_32116040 0.000 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.3 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 0.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3 1.0 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 0.6 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.2 0.5 GO:0003162 atrioventricular node development(GO:0003162)
0.1 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.1 0.6 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.1 0.3 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 1.9 GO:0010842 retina layer formation(GO:0010842)
0.1 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.6 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.7 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.6 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 1.0 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.3 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.1 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.6 GO:0051286 cell tip(GO:0051286)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.0 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032052 bile acid binding(GO:0032052)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 0.3 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.0 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1