Motif ID: Sox14

Z-value: 0.982


Transcription factors associated with Sox14:

Gene SymbolEntrez IDGene Name
Sox14 ENSMUSG00000053747.8 Sox14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox14mm10_v2_chr9_-_99876147_99876193-0.274.7e-02Click!


Activity profile for motif Sox14.

activity profile for motif Sox14


Sorted Z-values histogram for motif Sox14

Sorted Z-values for motif Sox14



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586675 7.481 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr11_+_67586520 7.398 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr13_-_14523178 6.047 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr12_+_109545390 4.746 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr4_+_102254739 4.586 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_23248264 4.332 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_167209149 4.258 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr18_-_43393346 4.151 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3
chr13_-_58113592 3.942 ENSMUST00000160860.1
 Klhl3
kelch-like 3
chr15_-_95528228 3.822 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr4_+_13751297 3.714 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_60197173 3.466 ENSMUST00000131670.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr3_+_65109343 3.451 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr14_-_121698417 3.285 ENSMUST00000040700.7
 Dock9
dedicator of cytokinesis 9
chr3_+_55461758 3.284 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr2_-_85196697 3.237 ENSMUST00000099930.2
ENSMUST00000111601.1
 Lrrc55

leucine rich repeat containing 55

chr8_-_105289465 3.117 ENSMUST00000171788.1
ENSMUST00000014981.6
 4931428F04Rik

RIKEN cDNA 4931428F04 gene

chr7_+_128688480 3.055 ENSMUST00000118605.1
 Inpp5f
inositol polyphosphate-5-phosphatase F
chr16_+_17144600 3.052 ENSMUST00000115702.1
 Ydjc
YdjC homolog (bacterial)
chr4_-_49593875 3.029 ENSMUST00000151542.1
 Tmem246
transmembrane protein 246

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.8 GO:0008360 regulation of cell shape(GO:0008360)
0.4 10.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.6 6.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 6.1 GO:0007416 synapse assembly(GO:0007416)
0.0 6.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 5.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.3 5.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 4.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.4 4.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.4 4.3 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.7 4.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 4.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 4.2 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.7 3.9 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 3.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 3.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.5 3.5 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 3.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 3.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 3.3 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0005884 actin filament(GO:0005884)
0.1 8.6 GO:0043204 perikaryon(GO:0043204)
0.1 6.1 GO:0042641 actomyosin(GO:0042641)
0.0 5.5 GO:0014069 postsynaptic density(GO:0014069)
1.3 5.0 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 4.8 GO:0043034 costamere(GO:0043034)
0.2 4.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.6 GO:0008021 synaptic vesicle(GO:0008021)
0.2 3.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 3.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 2.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 2.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 2.5 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.2 2.2 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 2.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 GO:0051015 actin filament binding(GO:0051015)
0.1 11.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 10.5 GO:0003779 actin binding(GO:0003779)
0.0 10.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 5.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.6 5.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 5.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 4.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 4.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 4.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.4 4.3 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 4.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 4.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.5 4.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 3.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 3.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 3.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.6 3.1 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 3.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.9 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.6 5.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 4.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.5 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.9 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 0.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 5.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 5.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 4.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.8 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates