Motif ID: Sox17

Z-value: 0.489


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.491.7e-04Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.962 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_11970540 3.924 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr10_+_127725392 3.165 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr14_+_50944499 2.922 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr8_-_105471481 2.916 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_135729147 2.400 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr2_+_102659213 2.384 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_+_24708241 2.162 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr10_-_128176568 2.152 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr11_-_77894096 2.149 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr2_-_127133909 2.083 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr2_-_180889660 2.015 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr6_-_148944750 1.897 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr14_+_31134853 1.746 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr1_+_52008210 1.668 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr19_+_55741810 1.628 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr13_-_35027077 1.190 ENSMUST00000170538.1
ENSMUST00000163280.1
 Eci2

enoyl-Coenzyme A delta isomerase 2

chr15_-_96460838 1.083 ENSMUST00000047835.6
 Scaf11
SR-related CTD-associated factor 11
chr2_+_52857844 0.925 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr4_+_118961578 0.857 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 3.9 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.8 3.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.0 2.9 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 2.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 2.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 2.4 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.4 GO:0001824 blastocyst development(GO:0001824)
0.1 2.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.7 2.1 GO:0006553 lysine metabolic process(GO:0006553)
0.7 2.1 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 1.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 1.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.9 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.1 0.8 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.1 0.8 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.4 GO:0042734 presynaptic membrane(GO:0042734)
0.4 2.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.7 2.1 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.9 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.8 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.7 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0034464 BBSome(GO:0034464)
0.0 0.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 2.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.4 2.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 2.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 2.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.6 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.2 1.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 0.9 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 0.8 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.8 GO:0008494 translation activator activity(GO:0008494)
0.1 0.7 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.7 GO:0070051 fibrinogen binding(GO:0070051)
0.2 0.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.5 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.5 GO:0090079 translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_IGF1_PATHWAY IGF1 pathway
0.0 2.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.7 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 2.9 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 2.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1