Motif ID: Sox18_Sox12

Z-value: 0.589

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox12mm10_v2_chr2_-_152398046_152398076-0.133.3e-01Click!
Sox18mm10_v2_chr2_-_181671622_181671645-0.009.9e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_113934679 2.054 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_55406163 1.627 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr14_+_62837679 1.552 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr16_-_91618986 1.523 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr8_-_67910911 1.484 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr11_-_11970540 1.431 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr18_-_88927447 1.286 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr2_+_102706356 1.281 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr2_-_59948155 1.246 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr14_-_100149764 1.228 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr14_+_116925379 1.182 ENSMUST00000088483.3
 Gpc6
glypican 6
chr7_+_127800604 1.173 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr2_+_102659213 1.116 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_+_24271568 1.053 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr2_-_84775420 1.025 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_-_62392605 1.008 ENSMUST00000151498.2
ENSMUST00000159069.1
 Ncor1

nuclear receptor co-repressor 1

chr1_+_165788681 0.979 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr16_-_50330987 0.977 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr13_-_25020289 0.940 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr8_-_22694061 0.924 ENSMUST00000131767.1
 Ikbkb
inhibitor of kappaB kinase beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 2.1 GO:0048840 otolith development(GO:0048840)
0.3 1.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 1.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 1.5 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 1.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 1.4 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 1.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 1.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 1.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 1.2 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.3 1.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 1.0 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.3 0.9 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.2 0.9 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.8 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.5 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 2.4 GO:0030673 axolemma(GO:0030673)
0.1 2.1 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.4 1.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.1 1.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.2 GO:0001772 immunological synapse(GO:0001772)
0.0 1.0 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.2 0.7 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.2 0.6 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 2.0 GO:0005158 insulin receptor binding(GO:0005158)
0.3 1.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.4 1.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.0 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.0 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.3 0.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 0.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 1.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.1 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1