Motif ID: Sox2

Z-value: 3.229


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.104.8e-01Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138842429 23.971 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr7_-_49636847 20.294 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr7_-_115824699 19.947 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr1_+_6734827 17.661 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr5_-_112228633 16.903 ENSMUST00000182699.1
ENSMUST00000182258.1
ENSMUST00000183036.1
 Miat


myocardial infarction associated transcript (non-protein coding)


chr7_-_116038734 16.788 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr9_+_118478851 16.350 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 15.675 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_+_45216671 15.654 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr5_-_98030727 15.191 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr10_+_26229707 14.568 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6487231 14.185 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chrX_-_143933089 13.212 ENSMUST00000087313.3
 Dcx
doublecortin
chr14_+_61138445 13.149 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chr2_+_181763315 13.066 ENSMUST00000081125.4
 Myt1
myelin transcription factor 1
chr4_+_62965560 12.899 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr17_-_35703971 12.790 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr7_-_37772868 12.673 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr6_-_56362356 12.278 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr3_-_75956888 12.145 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 444 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 55.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
3.9 46.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
3.4 41.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.8 41.2 GO:0048368 lateral mesoderm development(GO:0048368)
2.2 35.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.3 35.0 GO:0046548 retinal rod cell development(GO:0046548)
10.7 32.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.5 27.7 GO:0060539 diaphragm development(GO:0060539)
4.8 24.0 GO:0035262 gonad morphogenesis(GO:0035262)
7.9 23.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.3 22.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.6 21.9 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
1.5 19.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
3.2 19.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 16.9 GO:0001578 microtubule bundle formation(GO:0001578)
1.5 16.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
3.2 15.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
1.7 13.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 13.4 GO:0010508 positive regulation of autophagy(GO:0010508)
0.9 13.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 86.1 GO:0005634 nucleus(GO:0005634)
0.0 63.8 GO:0005654 nucleoplasm(GO:0005654)
0.2 60.8 GO:0005667 transcription factor complex(GO:0005667)
0.3 57.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 50.0 GO:0005794 Golgi apparatus(GO:0005794)
0.4 47.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 27.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 26.7 GO:0005871 kinesin complex(GO:0005871)
0.1 25.5 GO:0043235 receptor complex(GO:0043235)
8.1 24.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 23.2 GO:0005730 nucleolus(GO:0005730)
0.2 23.0 GO:0070160 occluding junction(GO:0070160)
0.1 22.0 GO:0005815 microtubule organizing center(GO:0005815)
0.9 21.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 21.1 GO:0016363 nuclear matrix(GO:0016363)
0.5 19.6 GO:0002102 podosome(GO:0002102)
2.1 18.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 16.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.0 16.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 16.7 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 69.6 GO:0003677 DNA binding(GO:0003677)
0.2 51.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9 48.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
5.2 47.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 38.4 GO:0030507 spectrin binding(GO:0030507)
1.9 36.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 31.6 GO:0001047 core promoter binding(GO:0001047)
0.2 30.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 29.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.4 26.6 GO:0003777 microtubule motor activity(GO:0003777)
0.4 24.7 GO:0035064 methylated histone binding(GO:0035064)
1.6 24.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 24.3 GO:0003723 RNA binding(GO:0003723)
0.1 23.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.2 23.3 GO:0035497 cAMP response element binding(GO:0035497)
3.0 20.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.7 20.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.0 19.8 GO:0030215 semaphorin receptor binding(GO:0030215)
2.4 19.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 18.4 GO:0035326 enhancer binding(GO:0035326)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 38.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.7 30.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 30.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.4 17.3 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.5 17.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 15.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 15.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 14.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 13.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 12.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 12.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.3 11.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 11.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 11.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.4 10.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 10.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 10.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 9.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.9 9.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 9.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 35.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.7 20.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.5 19.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 19.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.7 18.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.4 17.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.8 17.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.5 16.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 16.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.4 15.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 14.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 14.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 13.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 12.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.6 12.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.6 11.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 10.8 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
1.2 9.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 9.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 9.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes