Motif ID: Sox3_Sox10
Z-value: 1.587
Transcription factors associated with Sox3_Sox10:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox10 | ENSMUSG00000033006.9 | Sox10 |
| Sox3 | ENSMUSG00000045179.8 | Sox3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox3 | mm10_v2_chrX_-_60893430_60893440 | -0.64 | 1.1e-07 | Click! |
| Sox10 | mm10_v2_chr15_-_79164477_79164496 | -0.25 | 6.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 386 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 52.1 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.3 | 48.0 | GO:0007416 | synapse assembly(GO:0007416) |
| 3.6 | 32.6 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.8 | 30.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 1.9 | 25.0 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 1.6 | 24.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.3 | 20.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 2.7 | 19.2 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.4 | 18.7 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.0 | 18.5 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 1.6 | 17.1 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 2.1 | 17.0 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 3.4 | 16.8 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 1.8 | 16.0 | GO:0098907 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907) |
| 0.4 | 15.4 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 3.0 | 15.2 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 1.9 | 15.1 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 3.5 | 14.1 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 3.4 | 13.5 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.9 | 13.3 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 179 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 46.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 44.9 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 44.0 | GO:0005874 | microtubule(GO:0005874) |
| 3.9 | 39.0 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.6 | 37.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 1.5 | 36.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 3.0 | 27.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 26.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.3 | 22.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 21.5 | GO:0030017 | sarcomere(GO:0030017) |
| 1.3 | 20.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.4 | 20.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.2 | 19.6 | GO:0043204 | perikaryon(GO:0043204) |
| 1.3 | 19.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.3 | 18.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 5.5 | 16.4 | GO:0002142 | stereocilia ankle link complex(GO:0002142) |
| 0.6 | 16.0 | GO:0031430 | M band(GO:0031430) |
| 0.9 | 15.6 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 14.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.2 | 14.1 | GO:0043083 | synaptic cleft(GO:0043083) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 257 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 78.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.8 | 51.5 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 36.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 4.7 | 32.6 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 29.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 3.6 | 28.9 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.9 | 28.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 1.8 | 25.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 22.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 20.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 19.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.4 | 19.5 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.2 | 19.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 4.4 | 17.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 3.3 | 16.7 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 1.8 | 16.3 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.3 | 16.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.6 | 16.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.4 | 14.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 1.0 | 14.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 60 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 34.2 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.7 | 29.9 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.5 | 27.1 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.4 | 26.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.5 | 21.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.5 | 20.6 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.5 | 20.3 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.5 | 16.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.2 | 15.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 12.3 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 12.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.0 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.3 | 8.8 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 8.6 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 8.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 8.3 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.7 | 8.2 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 7.9 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.2 | 7.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 7.0 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 93 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.7 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.8 | 29.5 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 1.4 | 27.6 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.0 | 23.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.9 | 22.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 21.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 18.4 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 17.4 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.6 | 16.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 1.0 | 15.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.4 | 15.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 15.0 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 14.6 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.7 | 13.4 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.6 | 13.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 12.8 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 12.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.7 | 11.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 10.7 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 10.6 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
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