Motif ID: Sox4

Z-value: 0.791


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.143.2e-01Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_75005523 5.557 ENSMUST00000001927.5
Ltbp1
latent transforming growth factor beta binding protein 1
chr2_-_33942111 5.448 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr7_+_45216671 5.420 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr18_-_62756275 4.878 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr13_-_97747373 4.005 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 3.997 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_135729147 3.365 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr3_-_75956888 3.181 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr4_+_41762309 2.972 ENSMUST00000108042.2
Il11ra1
interleukin 11 receptor, alpha chain 1
chr17_-_35704000 2.883 ENSMUST00000097333.3
ENSMUST00000003628.6
Ddr1

discoidin domain receptor family, member 1

chr7_+_99466004 2.860 ENSMUST00000037359.2
Klhl35
kelch-like 35
chr17_-_35704574 2.787 ENSMUST00000117301.1
ENSMUST00000134995.1
Ddr1

discoidin domain receptor family, member 1

chr11_-_115813621 2.765 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr3_+_131110350 2.759 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1


lymphoid enhancer binding factor 1


chr1_+_165788681 2.691 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr4_-_91399984 2.660 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_-_70851189 2.633 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr12_-_54986363 2.362 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr1_+_165788746 2.289 ENSMUST00000161559.2
Cd247
CD247 antigen
chr9_-_103480328 2.250 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr9_+_85842852 2.152 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr6_-_39557830 2.114 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a

DENN/MADD domain containing 2A

chr11_+_88068242 1.911 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr17_-_35697971 1.737 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr2_-_180776900 1.727 ENSMUST00000108878.1
Bhlhe23
basic helix-loop-helix family, member e23
chr15_+_102296256 1.689 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr19_+_34922351 1.688 ENSMUST00000087341.5
Kif20b
kinesin family member 20B
chr5_+_115908644 1.669 ENSMUST00000141101.1
Cit
citron
chr7_-_105787544 1.564 ENSMUST00000078482.5
ENSMUST00000154659.1
Dchs1

dachsous 1 (Drosophila)

chrX_-_10117597 1.551 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
Srpx


sushi-repeat-containing protein


chrX_-_145505136 1.492 ENSMUST00000112835.1
Amot
angiomotin
chr6_-_38875965 1.476 ENSMUST00000160360.1
Hipk2
homeodomain interacting protein kinase 2
chr17_-_70853482 1.440 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chrX_-_145505175 1.413 ENSMUST00000143610.1
Amot
angiomotin
chr12_-_98577940 1.345 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr12_-_54986328 1.298 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr1_+_59482133 1.252 ENSMUST00000114246.2
ENSMUST00000037105.6
Fzd7

frizzled homolog 7 (Drosophila)

chr12_-_79296266 1.215 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr12_+_24708984 1.201 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr10_+_80151154 1.192 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr7_-_105752193 1.180 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr16_+_20516962 1.100 ENSMUST00000003318.5
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr7_-_105787567 1.074 ENSMUST00000144189.1
Dchs1
dachsous 1 (Drosophila)
chr2_-_180776749 1.035 ENSMUST00000061098.2
Bhlhe23
basic helix-loop-helix family, member e23
chr3_+_146500071 1.028 ENSMUST00000119130.1
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr11_+_69846374 0.981 ENSMUST00000108632.1
Plscr3
phospholipid scramblase 3
chr14_+_54936456 0.969 ENSMUST00000037814.6
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr11_-_100650693 0.964 ENSMUST00000103119.3
Zfp385c
zinc finger protein 385C
chr13_+_117220584 0.961 ENSMUST00000022242.7
Emb
embigin
chr9_+_104002546 0.961 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr7_+_100493795 0.939 ENSMUST00000129324.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr3_+_135826075 0.923 ENSMUST00000029810.5
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr5_-_31291026 0.861 ENSMUST00000041565.7
Ift172
intraflagellar transport 172
chr17_-_79020816 0.807 ENSMUST00000168887.1
ENSMUST00000119284.1
Prkd3

protein kinase D3

chr7_-_100514800 0.798 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr3_+_89164790 0.690 ENSMUST00000121212.2
ENSMUST00000152205.1
ENSMUST00000090927.5
ENSMUST00000148265.1
ENSMUST00000121931.1
Clk2




CDC-like kinase 2




chr5_-_138155694 0.667 ENSMUST00000132318.1
ENSMUST00000049393.8
Zfp113

zinc finger protein 113

chr10_+_80150448 0.667 ENSMUST00000153477.1
Midn
midnolin
chr7_+_100494044 0.664 ENSMUST00000153287.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr12_+_49385174 0.652 ENSMUST00000110746.1
3110039M20Rik
RIKEN cDNA 3110039M20 gene
chr5_+_3928033 0.641 ENSMUST00000143365.1
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr16_+_20517000 0.613 ENSMUST00000171572.1
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr5_-_131538687 0.610 ENSMUST00000161374.1
Auts2
autism susceptibility candidate 2
chr5_+_3928267 0.592 ENSMUST00000044492.8
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr16_+_84834901 0.549 ENSMUST00000114184.1
Gabpa
GA repeat binding protein, alpha
chr9_+_13765970 0.545 ENSMUST00000152532.1
Mtmr2
myotubularin related protein 2
chr14_+_27039001 0.526 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr8_-_11635745 0.509 ENSMUST00000033905.5
ENSMUST00000169782.1
Ankrd10

ankyrin repeat domain 10

chr11_+_69846610 0.468 ENSMUST00000152566.1
ENSMUST00000108633.2
Plscr3

phospholipid scramblase 3

chr14_+_47298260 0.468 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr1_+_158362330 0.452 ENSMUST00000170718.1
Astn1
astrotactin 1
chrX_+_71556874 0.377 ENSMUST00000123100.1
Hmgb3
high mobility group box 3
chr7_-_103853199 0.376 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_69846665 0.364 ENSMUST00000019605.2
Plscr3
phospholipid scramblase 3
chr6_-_47594967 0.357 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr1_+_181150926 0.341 ENSMUST00000134115.1
ENSMUST00000111059.1
Cnih4

cornichon homolog 4 (Drosophila)

chr18_-_15063560 0.338 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr6_-_47813512 0.325 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr5_-_122050102 0.323 ENSMUST00000154139.1
Cux2
cut-like homeobox 2
chr3_-_95133989 0.301 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1

sodium channel modifier 1

chr11_-_49187159 0.301 ENSMUST00000046522.6
Btnl9
butyrophilin-like 9
chr1_+_153665274 0.297 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr2_-_168206875 0.296 ENSMUST00000057793.4
Adnp
activity-dependent neuroprotective protein
chr1_-_55027473 0.296 ENSMUST00000027127.7
Sf3b1
splicing factor 3b, subunit 1
chr5_-_134456702 0.273 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr5_-_24445166 0.268 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr16_+_84835070 0.261 ENSMUST00000009120.7
Gabpa
GA repeat binding protein, alpha
chr5_-_24445254 0.253 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr16_-_91044473 0.249 ENSMUST00000118522.1
Paxbp1
PAX3 and PAX7 binding protein 1
chr11_+_101442440 0.243 ENSMUST00000107249.1
Rpl27
ribosomal protein L27
chr2_-_121806988 0.236 ENSMUST00000110592.1
Frmd5
FERM domain containing 5
chr11_+_22512088 0.226 ENSMUST00000059319.7
Tmem17
transmembrane protein 17
chr7_+_127233227 0.222 ENSMUST00000056232.6
Zfp553
zinc finger protein 553
chr5_-_114380459 0.209 ENSMUST00000001125.5
Kctd10
potassium channel tetramerisation domain containing 10
chr8_-_84773381 0.209 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr2_-_26910569 0.208 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr11_+_101442298 0.200 ENSMUST00000077856.6
Rpl27
ribosomal protein L27
chr11_-_98625661 0.191 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr18_-_43059418 0.175 ENSMUST00000025377.7
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr19_+_40831248 0.149 ENSMUST00000025983.6
ENSMUST00000120057.1
Ccnj

cyclin J

chr12_+_8674129 0.145 ENSMUST00000111123.2
ENSMUST00000178015.1
ENSMUST00000020915.3
Pum2


pumilio 2 (Drosophila)


chr5_-_114380505 0.134 ENSMUST00000102581.4
Kctd10
potassium channel tetramerisation domain containing 10
chr1_+_158362261 0.132 ENSMUST00000046110.9
Astn1
astrotactin 1
chr11_-_86807624 0.132 ENSMUST00000018569.7
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr11_-_106160101 0.121 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr12_+_24831583 0.094 ENSMUST00000110942.3
ENSMUST00000078902.6
Mboat2

membrane bound O-acyltransferase domain containing 2

chr12_+_19606929 0.094 ENSMUST00000105167.1
Gm9257
predicted gene 9257
chr9_-_32541589 0.090 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr10_-_17947997 0.077 ENSMUST00000037879.6
Heca
headcase homolog (Drosophila)
chr12_-_112674193 0.071 ENSMUST00000001780.3
Akt1
thymoma viral proto-oncogene 1
chr2_-_101649501 0.067 ENSMUST00000160722.1
ENSMUST00000160037.1
ENSMUST00000078494.5
B230118H07Rik

Rag1
RIKEN cDNA B230118H07 gene

recombination activating gene 1
chr7_+_127233044 0.055 ENSMUST00000106312.3
Zfp553
zinc finger protein 553
chr2_+_78869009 0.037 ENSMUST00000028398.7
Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr15_-_76656905 0.036 ENSMUST00000176274.1
Cyhr1
cysteine and histidine rich 1
chr2_-_165898951 0.035 ENSMUST00000136842.1
Zmynd8
zinc finger, MYND-type containing 8
chr2_-_125782834 0.033 ENSMUST00000053699.6
Secisbp2l
SECIS binding protein 2-like
chr5_+_44100442 0.029 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr13_+_51100810 0.015 ENSMUST00000095797.5
Spin1
spindlin 1
chrX_+_73639414 0.008 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.9 2.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.7 2.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.7 2.6 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.6 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 1.7 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.5 1.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 3.0 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.3 1.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.3 1.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.3 4.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 5.4 GO:0048368 lateral mesoderm development(GO:0048368)
0.2 5.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 0.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 3.0 GO:0046697 decidualization(GO:0046697)
0.2 1.6 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 1.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 5.0 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.5 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 2.2 GO:0070307 lens fiber cell development(GO:0070307)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.8 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.3 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 1.7 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 1.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.9 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.8 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 1.7 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.5 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 0.7 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0015671 oxygen transport(GO:0015671)
0.1 1.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 1.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.6 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.9 GO:0070986 left/right axis specification(GO:0070986)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.0 0.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.2 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 1.8 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 3.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 2.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.9 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 1.4 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.8 5.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.2 5.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.9 3.7 GO:0008623 CHRAC(GO:0008623)
0.3 1.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.3 1.0 GO:0097543 ciliary inversin compartment(GO:0097543)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.3 2.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 1.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.7 GO:1990909 Wnt signalosome(GO:1990909)
0.2 0.9 GO:0031090 organelle membrane(GO:0031090)
0.1 1.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 2.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 6.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.6 GO:0005776 autophagosome(GO:0005776)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0071004 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.7 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0050436 microfibril binding(GO:0050436)
0.8 7.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 3.0 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.6 2.9 GO:0043532 angiostatin binding(GO:0043532)
0.5 2.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.4 1.6 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 1.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.3 5.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 1.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 4.1 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.5 GO:0046790 virion binding(GO:0046790)
0.2 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 3.0 GO:0005109 frizzled binding(GO:0005109)
0.1 5.0 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.3 GO:0005112 Notch binding(GO:0005112)
0.1 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 7.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 4.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 5.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 4.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.