Motif ID: Sox5_Sry

Z-value: 1.624

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_143947092_1439471110.393.3e-03Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_115824699 14.946 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr11_+_94044111 10.556 ENSMUST00000132079.1
 Spag9
sperm associated antigen 9
chr3_+_127633134 9.728 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr2_-_60125651 9.203 ENSMUST00000112550.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_+_102658640 7.789 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_-_84086379 7.683 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr4_-_82505707 7.678 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr1_+_6730051 7.336 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr10_-_130280218 7.022 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr1_+_34005872 7.010 ENSMUST00000182296.1
 Dst
dystonin
chr10_+_69706326 6.254 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr7_-_37770757 6.093 ENSMUST00000176680.1
 Zfp536
zinc finger protein 536
chr6_+_15185456 5.835 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr2_+_124610573 5.777 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr1_+_6730135 5.468 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr1_-_119837613 5.382 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr4_-_82505274 5.329 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr12_-_99393010 5.268 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr9_-_72111172 5.216 ENSMUST00000183992.1
 Tcf12
transcription factor 12
chr5_+_17574268 5.193 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 22.6 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
2.0 21.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
5.3 21.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.2 19.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.6 17.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.9 11.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 9.9 GO:0043488 regulation of mRNA stability(GO:0043488)
1.1 7.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
2.6 7.7 GO:0060023 soft palate development(GO:0060023)
0.3 7.0 GO:0008090 retrograde axonal transport(GO:0008090)
2.3 6.8 GO:0007290 spermatid nucleus elongation(GO:0007290)
1.5 6.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.7 6.2 GO:0030035 microspike assembly(GO:0030035)
0.5 6.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 6.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.4 5.9 GO:0060013 righting reflex(GO:0060013)
0.1 5.8 GO:0006376 mRNA splice site selection(GO:0006376)
1.9 5.6 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 5.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 5.4 GO:0021591 ventricular system development(GO:0021591)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 21.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.0 21.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 20.8 GO:0005815 microtubule organizing center(GO:0005815)
0.1 17.4 GO:0032993 protein-DNA complex(GO:0032993)
0.1 14.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 11.3 GO:0016459 myosin complex(GO:0016459)
0.2 7.8 GO:0030673 axolemma(GO:0030673)
0.1 7.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 7.4 GO:0042788 polysomal ribosome(GO:0042788)
1.8 7.0 GO:0031673 H zone(GO:0031673)
0.2 6.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 6.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.6 5.7 GO:0030478 actin cap(GO:0030478)
0.1 5.7 GO:0072562 blood microparticle(GO:0072562)
0.1 5.2 GO:1990391 DNA repair complex(GO:1990391)
0.0 5.2 GO:0000785 chromatin(GO:0000785)
0.2 4.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.9 4.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 4.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 4.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 31.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 30.9 GO:0030507 spectrin binding(GO:0030507)
0.7 25.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.4 24.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 12.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 12.1 GO:0001047 core promoter binding(GO:0001047)
0.6 11.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 11.6 GO:0008017 microtubule binding(GO:0008017)
1.5 10.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.7 10.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 9.9 GO:0017091 AU-rich element binding(GO:0017091)
0.0 9.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 9.3 GO:0070888 E-box binding(GO:0070888)
0.1 8.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 8.4 GO:0035497 cAMP response element binding(GO:0035497)
1.3 7.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 6.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.2 6.2 GO:0043532 angiostatin binding(GO:0043532)
0.3 5.6 GO:0001848 complement binding(GO:0001848)
0.1 5.1 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 29.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 21.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 14.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 13.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 6.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 3.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 2.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.2 PID_RHOA_PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 21.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 12.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 11.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 10.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 8.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 7.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 6.0 REACTOME_MEIOSIS Genes involved in Meiosis
0.2 5.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 5.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 4.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 4.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 3.0 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.8 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)