Motif ID: Sox6_Sox9

Z-value: 0.799

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.359.3e-03Click!
Sox6mm10_v2_chr7_-_116038734_116038750-0.239.0e-02Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 6.347 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr18_+_37484955 5.225 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr9_+_27790947 4.699 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr8_-_84773381 4.655 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr17_-_68004075 4.647 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr17_+_55445550 4.438 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr6_+_17463749 4.271 ENSMUST00000115443.1
 Met
met proto-oncogene
chr5_+_66968559 4.168 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr10_-_83534130 3.972 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr5_+_66968416 3.819 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr13_-_97747399 3.784 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_+_180598219 3.440 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr1_-_56972437 3.297 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr11_-_106715251 3.233 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr9_-_29411736 3.049 ENSMUST00000115236.1
 Ntm
neurotrimin
chr6_+_86404336 3.040 ENSMUST00000113713.2
ENSMUST00000113708.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr5_+_3928033 2.811 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr6_+_86404257 2.797 ENSMUST00000095752.2
ENSMUST00000130967.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr6_-_12749193 2.767 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr9_-_79718631 2.765 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 GO:0007416 synapse assembly(GO:0007416)
0.9 8.5 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
1.3 8.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 5.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 4.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.3 4.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.5 4.6 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
1.2 4.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 4.5 GO:0007019 microtubule depolymerization(GO:0007019)
1.3 4.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 3.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 3.8 GO:0016574 histone ubiquitination(GO:0016574)
0.2 3.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.4 3.5 GO:0005513 detection of calcium ion(GO:0005513)
0.7 3.3 GO:0046684 response to pyrethroid(GO:0046684)
0.3 3.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.8 3.2 GO:0050904 diapedesis(GO:0050904)
0.0 3.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.4 2.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 9.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.9 8.5 GO:0097165 nuclear stress granule(GO:0097165)
2.6 7.8 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 6.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 5.5 GO:0005871 kinesin complex(GO:0005871)
1.2 4.8 GO:0044307 dendritic branch(GO:0044307)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.9 GO:0043235 receptor complex(GO:0043235)
0.4 3.8 GO:0001739 sex chromatin(GO:0001739)
0.9 3.4 GO:0005594 FACIT collagen trimer(GO:0005593) collagen type IX trimer(GO:0005594)
0.2 3.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 3.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.6 3.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.8 GO:0032420 stereocilium(GO:0032420)
0.0 2.6 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 8.6 GO:0015631 tubulin binding(GO:0015631)
2.0 8.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 6.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.5 6.3 GO:0050897 cobalt ion binding(GO:0050897)
1.1 5.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 5.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 5.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.9 GO:0044325 ion channel binding(GO:0044325)
0.7 4.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.3 4.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 3.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 3.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 3.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 2.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 2.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 2.4 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 6.5 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 5.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 4.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.6 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 0.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 7.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 5.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.5 4.6 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 4.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 3.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.4 2.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.7 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 1.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis