Motif ID: Sp1

Z-value: 1.707


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_1024063800.104.5e-01Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 20.777 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_+_134986191 16.120 ENSMUST00000094245.2
 Cldn3
claudin 3
chr2_+_172345565 14.942 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr1_-_56972437 14.638 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr9_+_44043384 13.273 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr8_-_84800024 13.229 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chrX_-_160994665 12.209 ENSMUST00000087104.4
 Cdkl5
cyclin-dependent kinase-like 5
chr12_-_100725028 11.830 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr2_-_33130565 11.513 ENSMUST00000124000.1
 Garnl3
GTPase activating RANGAP domain-like 3
chr12_+_70825492 11.450 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr12_-_4841583 11.382 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr4_-_133498538 11.139 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr12_+_12262139 10.929 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr18_+_24709436 10.462 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr16_+_93711907 10.147 ENSMUST00000045004.9
 Dopey2
dopey family member 2
chr2_+_76406529 10.140 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr8_-_29219338 10.074 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr1_-_161034794 9.986 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37


chrX_+_99975570 9.928 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr7_-_27396542 9.531 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,074 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 40.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.8 29.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.8 28.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.5 27.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.8 25.5 GO:0032456 endocytic recycling(GO:0032456)
1.3 23.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
2.6 23.7 GO:0032484 Ral protein signal transduction(GO:0032484)
3.1 21.5 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
5.3 21.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
2.6 20.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 20.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.9 20.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
4.9 19.8 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 19.6 GO:0006836 neurotransmitter transport(GO:0006836)
1.2 18.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.2 18.6 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
1.0 18.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
3.0 18.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 18.2 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
4.3 17.2 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 348 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 361.1 GO:0031224 intrinsic component of membrane(GO:0031224)
0.4 84.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 63.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 60.7 GO:0000139 Golgi membrane(GO:0000139)
0.3 55.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.6 50.3 GO:0030673 axolemma(GO:0030673)
0.5 44.3 GO:0055037 recycling endosome(GO:0055037)
0.2 34.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 32.8 GO:0008021 synaptic vesicle(GO:0008021)
0.2 31.8 GO:0014069 postsynaptic density(GO:0014069)
0.3 27.2 GO:0005770 late endosome(GO:0005770)
0.7 24.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 23.3 GO:0005802 trans-Golgi network(GO:0005802)
0.2 23.2 GO:0000118 histone deacetylase complex(GO:0000118)
1.3 22.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
1.7 22.4 GO:0044327 dendritic spine head(GO:0044327)
0.7 21.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.5 21.2 GO:0043083 synaptic cleft(GO:0043083)
0.7 20.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 20.7 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 617 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 106.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 51.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 46.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.6 30.8 GO:0030507 spectrin binding(GO:0030507)
0.4 30.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.2 29.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.6 28.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 26.8 GO:0015485 cholesterol binding(GO:0015485)
0.3 25.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 25.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 23.5 GO:0005262 calcium channel activity(GO:0005262)
1.3 23.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.0 21.5 GO:0043274 phospholipase binding(GO:0043274)
0.7 21.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.7 21.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
6.8 20.5 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
2.0 19.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
6.6 19.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
3.2 19.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.8 18.3 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 70.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.8 40.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 36.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 35.7 PID_SHP2_PATHWAY SHP2 signaling
2.0 34.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 30.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
1.1 27.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 27.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 24.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.4 22.9 PID_LKB1_PATHWAY LKB1 signaling events
0.5 18.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.7 15.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6 14.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 14.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9 13.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 13.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.8 13.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.5 12.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 12.1 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.3 12.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 54.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.1 42.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.9 29.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.7 28.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 27.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 23.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.2 21.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 20.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 20.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.2 19.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.7 18.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.8 18.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.0 18.1 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
1.4 17.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 17.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.9 17.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
1.1 17.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.7 16.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.8 16.1 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.2 16.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB