Motif ID: Sp100
Z-value: 2.987
Transcription factors associated with Sp100:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sp100 | ENSMUSG00000026222.10 | Sp100 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp100 | mm10_v2_chr1_+_85650044_85650052 | 0.12 | 3.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 25.7 | GO:0021764 | amygdala development(GO:0021764) |
| 4.6 | 27.5 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 4.2 | 29.4 | GO:0010273 | detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169) |
| 2.7 | 8.0 | GO:1990523 | bone regeneration(GO:1990523) |
| 2.3 | 16.3 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 2.2 | 13.3 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 2.1 | 6.2 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.9 | 17.0 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 1.7 | 5.1 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 1.6 | 6.6 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 1.6 | 8.1 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 1.5 | 8.8 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.4 | 4.2 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
| 1.3 | 9.2 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 1.3 | 3.9 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 1.3 | 40.2 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 1.1 | 3.4 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 1.1 | 12.4 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 1.1 | 8.8 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 1.0 | 7.2 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 1.0 | 4.0 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 1.0 | 8.6 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.9 | 11.9 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.8 | 2.4 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.8 | 16.0 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.8 | 12.9 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.7 | 6.6 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.7 | 7.7 | GO:0031441 | negative regulation of mRNA 3'-end processing(GO:0031441) |
| 0.6 | 11.5 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.6 | 1.9 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.6 | 10.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.6 | 3.6 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.5 | 2.6 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.5 | 1.5 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.5 | 1.5 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.5 | 7.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.5 | 4.3 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.4 | 4.8 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.4 | 2.6 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.4 | 25.0 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.4 | 2.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.4 | 2.5 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.4 | 7.1 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.4 | 3.2 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.4 | 9.7 | GO:0033687 | osteoblast proliferation(GO:0033687) |
| 0.4 | 1.8 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.4 | 3.5 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.3 | 17.3 | GO:0035307 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.3 | 3.5 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.3 | 0.9 | GO:0035630 | bone mineralization involved in bone maturation(GO:0035630) prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193) |
| 0.3 | 11.2 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.3 | 5.2 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.3 | 4.8 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.3 | 1.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.3 | 4.1 | GO:0051984 | positive regulation of chromosome segregation(GO:0051984) |
| 0.3 | 3.5 | GO:0036065 | fucosylation(GO:0036065) |
| 0.3 | 9.5 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.3 | 10.8 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 5.3 | GO:0048714 | positive regulation of oligodendrocyte differentiation(GO:0048714) |
| 0.2 | 1.7 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.2 | 2.1 | GO:0051103 | lagging strand elongation(GO:0006273) DNA ligation involved in DNA repair(GO:0051103) |
| 0.2 | 0.7 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
| 0.2 | 1.1 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 2.0 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 0.2 | 7.5 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.2 | 0.6 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.2 | 0.4 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.2 | 1.3 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
| 0.2 | 0.9 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
| 0.2 | 2.2 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 1.8 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.2 | 4.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.3 | GO:1905146 | lysosomal protein catabolic process(GO:1905146) |
| 0.1 | 4.6 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 10.4 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.1 | 0.7 | GO:0046016 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086) positive regulation of transcription by glucose(GO:0046016) |
| 0.1 | 1.7 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
| 0.1 | 0.5 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.1 | 1.2 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 2.0 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
| 0.1 | 4.2 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.1 | 14.5 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.1 | 1.3 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.1 | 9.9 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 5.3 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.1 | 1.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 3.4 | GO:0021511 | spinal cord patterning(GO:0021511) |
| 0.1 | 10.4 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
| 0.1 | 1.7 | GO:0019363 | pyridine nucleotide biosynthetic process(GO:0019363) |
| 0.1 | 0.7 | GO:1901299 | cellular response to hepatocyte growth factor stimulus(GO:0035729) negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299) |
| 0.1 | 2.2 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.1 | 4.9 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 0.8 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.1 | 4.0 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.1 | 5.0 | GO:0070613 | regulation of protein processing(GO:0070613) |
| 0.1 | 0.4 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.1 | 0.6 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 18.2 | GO:0007059 | chromosome segregation(GO:0007059) |
| 0.1 | 0.3 | GO:0060768 | epithelial cell proliferation involved in prostate gland development(GO:0060767) regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 2.3 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 3.8 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
| 0.0 | 0.9 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.8 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 1.0 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.0 | 1.1 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 2.7 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 1.4 | GO:0007088 | regulation of mitotic nuclear division(GO:0007088) |
| 0.0 | 2.3 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 1.3 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 1.9 | GO:0015992 | proton transport(GO:0015992) |
| 0.0 | 0.3 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.4 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 1.2 | GO:2000045 | regulation of G1/S transition of mitotic cell cycle(GO:2000045) |
| 0.0 | 0.7 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 1.2 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 19.4 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 3.2 | 12.9 | GO:0043293 | apoptosome(GO:0043293) |
| 2.8 | 27.5 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 1.6 | 4.8 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
| 1.4 | 4.3 | GO:0031417 | NatC complex(GO:0031417) |
| 1.2 | 37.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 1.2 | 3.5 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 1.1 | 13.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.9 | 5.7 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.9 | 7.9 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.7 | 20.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.7 | 3.6 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.6 | 4.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.6 | 11.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.6 | 1.7 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.6 | 5.1 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.5 | 6.6 | GO:0010369 | chromocenter(GO:0010369) |
| 0.5 | 12.9 | GO:0001741 | XY body(GO:0001741) |
| 0.5 | 4.8 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.5 | 11.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.4 | 7.1 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.4 | 1.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.4 | 1.1 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.4 | 8.0 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.3 | 4.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 6.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.3 | 6.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.3 | 0.9 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.3 | 3.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 3.8 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 17.0 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.2 | 12.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 5.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 1.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 2.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 14.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.2 | 11.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 1.8 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.2 | 0.5 | GO:1990047 | spindle matrix(GO:1990047) |
| 0.2 | 1.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.2 | 4.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 4.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 2.7 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 1.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 2.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.1 | 6.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 1.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.8 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 3.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 6.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.1 | 2.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 3.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 1.8 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 1.9 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 3.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 5.3 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.3 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 4.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 1.5 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 12.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 344.3 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 17.0 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 5.5 | 27.5 | GO:0043515 | kinetochore binding(GO:0043515) |
| 2.7 | 8.1 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 2.3 | 16.0 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 1.5 | 6.2 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.3 | 16.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 1.3 | 3.9 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 1.2 | 5.8 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 1.1 | 3.4 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 1.1 | 8.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.9 | 3.5 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.9 | 2.6 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.8 | 8.2 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.8 | 3.2 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.7 | 4.8 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.7 | 5.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.6 | 11.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.6 | 12.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.6 | 4.2 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.6 | 11.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.6 | 4.1 | GO:0000403 | Y-form DNA binding(GO:0000403) |
| 0.6 | 29.4 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.5 | 4.2 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.5 | 2.4 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.5 | 21.6 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.5 | 23.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 3.5 | GO:0046790 | virion binding(GO:0046790) |
| 0.4 | 2.4 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.4 | 2.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 13.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.4 | 2.1 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.3 | 8.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.3 | 2.0 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.3 | 7.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.3 | 25.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.3 | 13.2 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.3 | 1.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 6.2 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.3 | 6.5 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.3 | 13.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.3 | 0.8 | GO:0000992 | polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) |
| 0.2 | 5.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.2 | 5.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.2 | 4.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 0.8 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.2 | 3.2 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.2 | 4.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 6.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 3.6 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 1.5 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
| 0.1 | 2.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 0.5 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 2.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 2.2 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 4.5 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 1.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 0.6 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 2.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 17.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 1.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 3.4 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 2.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 1.5 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 1.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 6.4 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 14.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 4.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 0.3 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 2.0 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.2 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.1 | 5.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 4.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 8.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 1.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.6 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.1 | 1.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 22.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 0.9 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 1.8 | GO:0004620 | phospholipase activity(GO:0004620) |
| 0.0 | 0.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 1.7 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 4.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.7 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.0 | 227.1 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 17.0 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 37.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 20.8 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 11.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 13.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 4.8 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.3 | 8.0 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.2 | 9.2 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.2 | 13.5 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 4.0 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 6.3 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 8.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 11.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 7.2 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 4.9 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.1 | 0.9 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.1 | 3.2 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 5.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.2 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.0 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 16.0 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 1.7 | 17.0 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.8 | 6.6 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.8 | 39.0 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.6 | 11.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.6 | 7.2 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.4 | 3.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.4 | 6.5 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.4 | 25.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 8.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.3 | 8.1 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.3 | 5.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.3 | 3.9 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.3 | 10.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 11.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.2 | 6.1 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.2 | 13.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.2 | 5.3 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 4.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 13.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.9 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 4.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.0 | REACTOME_PHOSPHORYLATION_OF_THE_APC_C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 1.7 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 9.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.8 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 7.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.2 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 4.2 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 1.2 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 1.3 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.3 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.1 | 5.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.2 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 1.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 0.7 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.2 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 6.7 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 4.8 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.3 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.3 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.3 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.9 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 3.2 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.4 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 1.0 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
