Motif ID: Sp100

Z-value: 2.987


Transcription factors associated with Sp100:

Gene SymbolEntrez IDGene Name
Sp100 ENSMUSG00000026222.10 Sp100

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp100mm10_v2_chr1_+_85650044_856500520.123.8e-01Click!


Activity profile for motif Sp100.

activity profile for motif Sp100


Sorted Z-values histogram for motif Sp100

Sorted Z-values for motif Sp100



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp100

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3023547 77.915 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 75.305 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr14_-_19418930 66.483 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3025417 64.804 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_-_98667264 60.842 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3004457 57.177 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3018753 56.707 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3017408 56.679 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3027439 47.152 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3000922 46.002 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3036877 45.632 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3015654 40.620 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr8_+_94179089 29.361 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr14_+_65806066 29.188 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr3_+_135212557 27.540 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr10_-_42583628 25.737 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_-_4779513 23.400 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr13_-_23762378 21.872 ENSMUST00000091701.2
 Hist1h3a
histone cluster 1, H3a
chr3_-_88410295 19.391 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr14_-_67715585 17.340 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 40.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
4.2 29.4 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
4.6 27.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
5.1 25.7 GO:0021764 amygdala development(GO:0021764)
0.4 25.0 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 18.2 GO:0007059 chromosome segregation(GO:0007059)
0.3 17.3 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
1.9 17.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
2.3 16.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.8 16.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 14.5 GO:0051028 mRNA transport(GO:0051028)
2.2 13.3 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.8 12.9 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.1 12.4 GO:0006228 UTP biosynthetic process(GO:0006228)
0.9 11.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.6 11.5 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 11.2 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 10.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 10.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 10.4 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 344.3 GO:0005575 cellular_component(GO:0005575)
1.2 37.9 GO:0000788 nuclear nucleosome(GO:0000788)
2.8 27.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.7 20.8 GO:0005721 pericentric heterochromatin(GO:0005721)
3.2 19.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 17.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 14.6 GO:0072686 mitotic spindle(GO:0072686)
1.1 13.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
3.2 12.9 GO:0043293 apoptosome(GO:0043293)
0.5 12.9 GO:0001741 XY body(GO:0001741)
0.2 12.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 12.1 GO:0005667 transcription factor complex(GO:0005667)
0.5 11.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.6 11.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 11.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 8.0 GO:0031527 filopodium membrane(GO:0031527)
0.9 7.9 GO:0097427 microtubule bundle(GO:0097427)
0.4 7.1 GO:0035102 PRC1 complex(GO:0035102)
0.5 6.6 GO:0010369 chromocenter(GO:0010369)
0.3 6.4 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 227.1 GO:0003674 molecular_function(GO:0003674)
0.6 29.4 GO:0005507 copper ion binding(GO:0005507)
5.5 27.5 GO:0043515 kinetochore binding(GO:0043515)
0.3 25.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.5 23.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 22.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.5 21.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 17.4 GO:0051015 actin filament binding(GO:0051015)
5.7 17.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.3 16.1 GO:0043522 leucine zipper domain binding(GO:0043522)
2.3 16.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 14.5 GO:0042393 histone binding(GO:0042393)
0.4 13.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 13.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 13.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.6 12.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.6 11.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.6 11.2 GO:0004383 guanylate cyclase activity(GO:0004383)
1.1 8.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 8.5 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 37.6 PID_PLK1_PATHWAY PLK1 signaling events
0.5 20.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.9 17.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 13.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 13.3 NABA_COLLAGENS Genes encoding collagen proteins
0.4 11.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 11.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 9.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 8.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 8.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 7.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 6.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 5.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.9 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.3 4.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 4.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 4.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 3.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 39.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 25.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.7 17.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.8 16.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 13.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 13.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.6 11.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 11.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 10.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 9.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 8.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 8.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 7.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 6.7 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.8 6.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 6.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 6.1 REACTOME_KINESINS Genes involved in Kinesins
0.2 5.3 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 5.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport