Motif ID: Sp2

Z-value: 0.504


Transcription factors associated with Sp2:

Gene SymbolEntrez IDGene Name
Sp2 ENSMUSG00000018678.6 Sp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp2mm10_v2_chr11_-_96977660_969777110.201.4e-01Click!


Activity profile for motif Sp2.

activity profile for motif Sp2


Sorted Z-values histogram for motif Sp2

Sorted Z-values for motif Sp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 6.181 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr1_+_184034381 3.038 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr12_+_112644828 2.666 ENSMUST00000021728.4
ENSMUST00000109755.3
 Siva1

SIVA1, apoptosis-inducing factor

chr7_-_110061319 2.588 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr1_+_72824482 2.088 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_184033998 2.033 ENSMUST00000050306.5
 1700056E22Rik
RIKEN cDNA 1700056E22 gene
chr12_+_112678803 1.919 ENSMUST00000174780.1
ENSMUST00000169593.1
ENSMUST00000173942.1
 Zbtb42


zinc finger and BTB domain containing 42


chr2_-_129297205 1.776 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr3_+_69004711 1.743 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr4_+_46450892 1.710 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_17062384 1.562 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit

chr3_+_69004969 1.530 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr8_+_116921735 1.528 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr17_-_70851189 1.526 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr8_-_61591130 1.490 ENSMUST00000135439.1
ENSMUST00000121200.1
 Palld

palladin, cytoskeletal associated protein

chr4_+_3938888 1.485 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr18_+_82914632 1.437 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr6_+_85187438 1.436 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr2_+_38339258 1.424 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr11_+_101468164 1.380 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 4.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 3.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6 3.0 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 2.9 GO:0021978 telencephalon regionalization(GO:0021978)
0.8 2.5 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 2.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 2.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 2.0 GO:0097402 neuroblast migration(GO:0097402)
0.5 1.9 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 1.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.8 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.0 1.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.7 GO:0043486 histone exchange(GO:0043486)
0.2 1.6 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.5 GO:0003334 keratinocyte development(GO:0003334)
0.5 1.4 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.5 1.4 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 1.4 GO:0007144 female meiosis I(GO:0007144)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 GO:0016607 nuclear speck(GO:0016607)
0.4 4.1 GO:0000796 condensin complex(GO:0000796)
0.0 3.9 GO:0072562 blood microparticle(GO:0072562)
0.0 3.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 2.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 2.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.9 GO:0045120 pronucleus(GO:0045120)
0.0 1.8 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.5 GO:0000922 spindle pole(GO:0000922)
0.0 1.4 GO:0002102 podosome(GO:0002102)
0.4 1.3 GO:1990423 RZZ complex(GO:1990423)
0.2 1.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 1.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.1 GO:0045180 basal cortex(GO:0045180)
0.2 1.0 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 6.2 GO:0019841 retinol binding(GO:0019841)
0.0 4.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 3.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 2.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.5 GO:0001848 complement binding(GO:0001848)
0.3 2.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 1.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 1.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.2 1.6 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.2 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.0 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 1.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_P73PATHWAY p73 transcription factor network
0.1 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 0.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 2.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 2.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 2.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.1 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.2 2.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.8 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.1 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation