Motif ID: Spdef

Z-value: 0.481


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_27728956-0.266.0e-02Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_90243073 2.115 ENSMUST00000107369.1
 Creb3l4
cAMP responsive element binding protein 3-like 4
chr10_+_58813359 1.759 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr14_-_70207637 1.522 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr14_+_54254124 1.513 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr9_+_80165079 1.477 ENSMUST00000184480.1
 Myo6
myosin VI
chr14_+_28511344 1.463 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr15_-_89170688 1.396 ENSMUST00000060808.9
 Plxnb2
plexin B2
chr17_+_35049966 1.297 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chrX_+_100625737 1.267 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr9_+_65908967 1.252 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr9_+_30427329 1.230 ENSMUST00000164099.1
 Snx19
sorting nexin 19
chr4_-_107923519 1.213 ENSMUST00000106719.1
ENSMUST00000106720.2
ENSMUST00000131644.1
ENSMUST00000030345.8
 Cpt2



carnitine palmitoyltransferase 2



chr9_+_80165013 1.173 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr18_+_34861200 1.168 ENSMUST00000165033.1
 Egr1
early growth response 1
chrX_+_101254528 1.159 ENSMUST00000062000.4
 Foxo4
forkhead box O4
chr17_+_88626569 1.156 ENSMUST00000150023.1
 Ston1
stonin 1
chr13_+_12395362 1.129 ENSMUST00000059270.8
 Heatr1
HEAT repeat containing 1
chr1_+_61638819 1.112 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr13_-_60177357 1.099 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr13_-_19619820 1.088 ENSMUST00000002885.6
 Epdr1
ependymin related protein 1 (zebrafish)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 1.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.5 1.5 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.0 1.5 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.5 GO:0008033 tRNA processing(GO:0008033)
0.5 1.4 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.1 1.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.4 1.2 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 1.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.2 GO:0070317 negative regulation of smooth muscle cell differentiation(GO:0051151) negative regulation of G0 to G1 transition(GO:0070317)
0.1 1.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 1.2 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 1.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.2 1.1 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 1.1 GO:0042473 outer ear morphogenesis(GO:0042473)
0.0 1.1 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.1 1.0 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.5 GO:0032432 actin filament bundle(GO:0032432)
0.2 1.4 GO:0000322 storage vacuole(GO:0000322)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.9 GO:0008623 CHRAC(GO:0008623)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.3 0.8 GO:0000801 central element(GO:0000801)
0.1 0.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0017166 vinculin binding(GO:0017166)
0.0 2.1 GO:0003774 motor activity(GO:0003774)
0.3 1.9 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.5 1.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.3 1.4 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 1.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.4 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 1.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 1.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.1 GO:0030515 snoRNA binding(GO:0030515)
0.2 1.0 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.8 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.4 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.2 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript