Motif ID: Spib

Z-value: 1.724


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 40.776 ENSMUST00000100572.3
 Sla
src-like adaptor
chr4_-_136898803 17.114 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_136886187 16.418 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr4_-_136892867 16.324 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr5_+_81021202 14.320 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3

chr6_+_137410721 14.188 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr16_+_41532851 13.913 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr1_-_171059390 13.306 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr3_-_87263518 11.676 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr2_+_121357714 10.856 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr10_+_81257277 10.597 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr17_-_67950908 10.548 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr1_-_171234290 10.139 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr12_-_86988676 9.794 ENSMUST00000095521.2
 Zdhhc22
zinc finger, DHHC-type containing 22
chr17_-_68004075 9.338 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr4_+_130913120 9.046 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr18_-_35215008 8.713 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr2_+_14229390 8.620 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr6_-_136941694 8.616 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_-_87263703 8.611 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 63.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.6 33.5 GO:0006958 complement activation, classical pathway(GO:0006958)
8.8 26.4 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
5.0 19.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 17.9 GO:0032091 negative regulation of protein binding(GO:0032091)
2.3 16.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
2.4 14.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.8 14.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.5 13.9 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 13.2 GO:0071277 cellular response to calcium ion(GO:0071277)
2.1 12.5 GO:0032796 uropod organization(GO:0032796)
4.0 12.0 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
2.4 11.8 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 9.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.5 8.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 8.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 8.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
1.0 7.9 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
1.8 7.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 7.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 55.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 46.7 GO:0005581 collagen trimer(GO:0005581)
0.2 45.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 27.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 15.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 15.4 GO:0005794 Golgi apparatus(GO:0005794)
0.2 14.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 13.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 13.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 12.9 GO:0043204 perikaryon(GO:0043204)
1.1 12.5 GO:0032426 stereocilium tip(GO:0032426)
2.3 9.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 8.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 8.2 GO:0045202 synapse(GO:0045202)
0.4 7.5 GO:0071564 npBAF complex(GO:0071564)
1.5 7.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
2.3 6.9 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.5 6.8 GO:0042581 specific granule(GO:0042581)
0.9 6.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 6.1 GO:0097449 astrocyte projection(GO:0097449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 54.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 35.4 GO:0005096 GTPase activator activity(GO:0005096)
5.7 34.2 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.0 23.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 22.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
4.8 19.1 GO:0004111 creatine kinase activity(GO:0004111)
0.4 16.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
2.1 14.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.1 12.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 11.5 GO:0030246 carbohydrate binding(GO:0030246)
0.6 9.2 GO:0005537 mannose binding(GO:0005537)
0.5 8.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 8.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 7.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 7.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 7.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 7.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 6.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.4 6.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 6.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 46.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 36.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 25.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.5 22.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.4 18.5 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 16.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.4 12.1 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.3 8.6 PID_ARF_3PATHWAY Arf1 pathway
0.3 7.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.3 7.6 PID_BCR_5PATHWAY BCR signaling pathway
0.3 7.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 6.8 ST_ADRENERGIC Adrenergic Pathway
0.1 6.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 5.7 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 3.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 3.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 2.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.3 49.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 34.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 14.6 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.4 13.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 13.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.9 10.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.5 10.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 8.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 8.1 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.4 7.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 7.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 6.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 6.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 6.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 6.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 5.7 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 5.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 4.5 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.0 4.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors