Motif ID: Srf
Z-value: 1.089
Transcription factors associated with Srf:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Srf | ENSMUSG00000015605.5 | Srf |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Srf | mm10_v2_chr17_-_46556158_46556188 | -0.28 | 3.8e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.2 | GO:0072223 | metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 1.9 | 7.6 | GO:0030091 | protein repair(GO:0030091) |
| 1.4 | 8.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.8 | 2.4 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.6 | 3.1 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.6 | 1.2 | GO:0035793 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591) |
| 0.6 | 2.3 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.4 | 2.5 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.3 | 3.4 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.3 | 2.9 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.3 | 4.0 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.3 | 1.0 | GO:0050689 | negative regulation of interferon-beta biosynthetic process(GO:0045358) negative regulation of defense response to virus by host(GO:0050689) |
| 0.3 | 1.5 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.2 | 1.5 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.2 | 0.7 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 1.6 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.2 | 0.6 | GO:2000836 | positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845) |
| 0.2 | 1.0 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.2 | 1.7 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.2 | 1.1 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.2 | 0.7 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.2 | 0.5 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.2 | 3.3 | GO:0035994 | response to muscle stretch(GO:0035994) |
| 0.2 | 0.5 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.1 | 1.1 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 1.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.8 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 2.0 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
| 0.1 | 1.7 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 5.4 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
| 0.1 | 2.7 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 0.9 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.5 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351) |
| 0.1 | 4.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.3 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 2.9 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.1 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.0 | 0.1 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.0 | 1.0 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 0.7 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.0 | 0.1 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) Golgi reassembly(GO:0090168) |
| 0.0 | 0.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 1.4 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.0 | 0.1 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 1.0 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.0 | 2.3 | GO:0006457 | protein folding(GO:0006457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.5 | 3.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.5 | 2.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.4 | 1.5 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 1.1 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.2 | 4.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.7 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 0.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.0 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 1.4 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 0.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.1 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 1.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.3 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.1 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 5.5 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.0 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 12.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 1.3 | 7.6 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.3 | 1.5 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.2 | 0.7 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
| 0.2 | 1.1 | GO:0002135 | CTP binding(GO:0002135) sulfonylurea receptor binding(GO:0017098) |
| 0.2 | 2.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 1.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.2 | 1.0 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.2 | 1.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.2 | 1.0 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.2 | 1.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 0.5 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 1.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.8 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 3.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 0.2 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 1.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.7 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 0.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 2.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 1.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 3.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 3.4 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.7 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 2.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.1 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.0 | 6.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.1 | GO:0043539 | insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 2.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 6.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.1 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.2 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.2 | 3.3 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.9 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 3.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.2 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.0 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.2 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 3.3 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 1.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 2.6 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.1 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 2.0 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.0 | 1.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
