Motif ID: Srf

Z-value: 1.089


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.283.8e-02Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 12.156 ENSMUST00000165033.1
Egr1
early growth response 1
chr6_-_23248264 8.505 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr10_-_120899067 7.617 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr7_-_19310035 4.399 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr12_+_85473883 3.263 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr4_+_43957678 3.011 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr13_+_51846673 2.879 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr14_+_3049285 2.804 ENSMUST00000166494.1
Gm2897
predicted gene 2897
chr14_-_7568566 2.739 ENSMUST00000163790.1
Gm3558
predicted gene 3558
chr14_-_5389049 2.652 ENSMUST00000177986.1
Gm3500
predicted gene 3500
chr14_-_6287250 2.616 ENSMUST00000170104.2
Gm3411
predicted gene 3411
chr14_+_4415448 2.616 ENSMUST00000168866.1
Gm3164
predicted gene 3164
chr14_+_5071040 2.584 ENSMUST00000163719.1
Gm8281
predicted gene, 8281
chr3_-_57575907 2.540 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr14_+_4726775 2.489 ENSMUST00000165619.1
Gm3252
predicted gene 3252
chr14_-_5880382 2.453 ENSMUST00000164484.1
Gm8237
predicted gene 8237
chr4_+_43957401 2.443 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr4_+_137862237 2.439 ENSMUST00000102518.3
Ece1
endothelin converting enzyme 1
chr14_-_6889962 2.330 ENSMUST00000171906.1
Gm3667
predicted gene 3667
chr14_+_4334763 2.322 ENSMUST00000165466.1
2610042L04Rik
RIKEN cDNA 2610042L04 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 12.2 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
1.4 8.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.9 7.6 GO:0030091 protein repair(GO:0030091)
0.1 5.4 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 4.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 4.0 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.3 3.4 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.2 3.3 GO:0035994 response to muscle stretch(GO:0035994)
0.6 3.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 2.9 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.0 2.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.7 GO:0001706 endoderm formation(GO:0001706)
0.4 2.5 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 2.4 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.6 2.3 GO:0060025 regulation of synaptic activity(GO:0060025)
0.0 2.3 GO:0006457 protein folding(GO:0006457)
0.1 2.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.2 1.7 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 1.6 GO:0048739 cardiac muscle fiber development(GO:0048739)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0000139 Golgi membrane(GO:0000139)
0.2 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 3.3 GO:0035976 AP1 complex(GO:0035976)
0.5 3.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 2.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.7 GO:0000124 SAGA complex(GO:0000124)
0.4 1.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.4 GO:0016460 myosin II complex(GO:0016460)
0.0 1.2 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0005902 microvillus(GO:0005902)
0.2 1.1 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0070938 contractile ring(GO:0070938)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 12.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.3 7.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 6.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 6.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.4 GO:0002039 p53 binding(GO:0002039)
0.1 3.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 3.1 GO:0035064 methylated histone binding(GO:0035064)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 1.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.1 GO:0002135 CTP binding(GO:0002135) sulfonylurea receptor binding(GO:0017098)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.2 3.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 3.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.2 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 3.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 1.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events