Motif ID: Stat1

Z-value: 0.748


Transcription factors associated with Stat1:

Gene SymbolEntrez IDGene Name
Stat1 ENSMUSG00000026104.8 Stat1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_52119499-0.182.0e-01Click!


Activity profile for motif Stat1.

activity profile for motif Stat1


Sorted Z-values histogram for motif Stat1

Sorted Z-values for motif Stat1



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat1

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 7.377 ENSMUST00000017488.4
 Vtn
vitronectin
chr3_-_80802789 6.569 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 5.185 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr17_-_68004075 5.071 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr15_-_93519499 4.564 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr11_+_101245996 4.065 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr12_+_74297474 3.973 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr1_-_155417394 3.895 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr3_-_10440054 3.703 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chr4_-_136886187 3.691 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_+_45783686 3.683 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr9_+_20868628 3.683 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr4_+_43401232 3.526 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr10_+_69925954 3.411 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr7_+_45783883 3.382 ENSMUST00000072580.5
 Lmtk3
lemur tyrosine kinase 3
chr10_+_69925766 3.286 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr7_+_24134148 3.258 ENSMUST00000056549.7
 Zfp235
zinc finger protein 235
chr16_-_42340595 3.138 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr1_-_155417283 3.019 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr13_+_109903089 2.984 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.7 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.1 7.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.2 6.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 6.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 6.5 GO:0034340 response to type I interferon(GO:0034340)
0.0 5.4 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
1.3 5.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.5 4.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.7 4.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 3.8 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.2 3.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 3.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 3.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.9 3.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 3.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 3.3 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 3.3 GO:0006275 regulation of DNA replication(GO:0006275)
0.5 3.1 GO:0016198 axon choice point recognition(GO:0016198)
0.2 3.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.3 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.6 11.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.5 7.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 6.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 5.7 GO:0005581 collagen trimer(GO:0005581)
0.8 4.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 3.8 GO:0031965 nuclear membrane(GO:0031965)
0.5 3.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 3.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 3.4 GO:0042825 TAP complex(GO:0042825)
0.2 3.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.7 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.0 2.2 GO:0055037 recycling endosome(GO:0055037)
0.3 2.1 GO:0070695 FHF complex(GO:0070695)
0.5 2.0 GO:0031673 H zone(GO:0031673)
0.5 1.9 GO:0090537 CERF complex(GO:0090537)
0.1 1.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.6 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.3 GO:0030507 spectrin binding(GO:0030507)
0.5 7.4 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
2.3 6.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.1 6.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 4.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.2 4.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 4.1 GO:0097643 amylin receptor activity(GO:0097643)
0.1 3.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.9 3.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 3.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.9 3.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 3.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 3.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.0 GO:0005518 collagen binding(GO:0005518)
0.7 2.8 GO:0019962 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.4 2.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 2.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.4 7.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 3.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 3.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.5 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.2 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 1.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 6.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 6.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 5.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.9 5.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 4.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 2.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.2 2.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.7 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 2.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.0 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression