Motif ID: Stat2

Z-value: 2.389


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.501.2e-04Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_173942445 28.650 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr12_+_103434211 23.702 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 21.457 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr3_-_107760221 15.080 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr6_+_121245903 14.856 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr16_+_23609895 14.036 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr16_+_42907563 13.866 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43363855 13.365 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751946 12.526 ENSMUST00000183241.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_43364145 11.209 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751859 11.168 ENSMUST00000182538.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_43235856 11.035 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_-_156674290 10.953 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr4_-_154636831 10.891 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr2_+_4559742 10.307 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr6_-_39118211 9.414 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_+_153749496 9.376 ENSMUST00000182722.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr6_+_90550789 9.360 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr12_-_78980758 9.346 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr1_-_170110491 9.342 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 107.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
1.5 49.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.1 32.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 26.3 GO:0046825 regulation of protein export from nucleus(GO:0046825)
5.1 15.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.9 14.9 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.3 14.7 GO:0001919 regulation of receptor recycling(GO:0001919)
4.7 14.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
3.2 12.8 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.4 10.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
2.6 10.6 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
1.9 9.7 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
2.4 9.5 GO:0044565 dendritic cell proliferation(GO:0044565)
3.1 9.4 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
1.2 9.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.6 9.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.9 8.7 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 8.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
2.8 8.5 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.1 8.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 70.2 GO:0005634 nucleus(GO:0005634)
0.4 41.6 GO:0016363 nuclear matrix(GO:0016363)
0.1 37.7 GO:0045177 apical part of cell(GO:0045177)
0.0 32.9 GO:0005739 mitochondrion(GO:0005739)
0.0 26.0 GO:0005730 nucleolus(GO:0005730)
0.6 23.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 19.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 17.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 16.4 GO:0005667 transcription factor complex(GO:0005667)
5.0 15.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.0 14.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 12.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 12.8 GO:0009986 cell surface(GO:0009986)
0.3 12.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.8 11.8 GO:0044754 autolysosome(GO:0044754)
0.2 10.9 GO:0016235 aggresome(GO:0016235)
0.0 8.5 GO:0005615 extracellular space(GO:0005615)
0.0 8.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 7.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 6.5 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 76.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 41.6 GO:0019843 rRNA binding(GO:0019843)
1.0 23.7 GO:0005521 lamin binding(GO:0005521)
0.1 21.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.9 19.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 16.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 15.1 GO:0008083 growth factor activity(GO:0008083)
2.1 14.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 14.6 GO:0003924 GTPase activity(GO:0003924)
3.3 13.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 11.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 10.9 GO:0046332 SMAD binding(GO:0046332)
0.1 10.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 9.9 GO:0003727 single-stranded RNA binding(GO:0003727)
3.1 9.4 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
1.0 9.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.7 8.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.6 8.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 8.6 GO:0017137 Rab GTPase binding(GO:0017137)
2.8 8.5 GO:0005110 frizzled-2 binding(GO:0005110)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.2 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
1.5 15.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 14.5 PID_SHP2_PATHWAY SHP2 signaling
0.1 9.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 8.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 8.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 6.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 6.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 5.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 4.3 PID_MYC_PATHWAY C-MYC pathway
0.1 4.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.2 4.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 4.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.4 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.3 3.1 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.3 SIG_CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 119.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
1.2 16.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.6 14.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 7.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 6.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 6.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 6.0 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 5.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 4.7 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.2 4.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 4.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 3.9 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 3.3 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.1 3.1 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 3.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 1.5 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle