Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.883

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.592.0e-06Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.384.4e-03Click!
Stat3mm10_v2_chr11_-_100939457_1009394840.057.2e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 10.186 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 6.842 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr17_+_26715644 4.166 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr1_+_34005872 3.397 ENSMUST00000182296.1
 Dst
dystonin
chr16_-_74411776 3.224 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr17_-_68004075 3.155 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr4_+_148602527 3.101 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr16_-_23988852 3.066 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr4_-_108031938 3.060 ENSMUST00000106708.1
 Podn
podocan
chr4_-_64046925 3.035 ENSMUST00000107377.3
 Tnc
tenascin C
chr13_-_67755132 2.960 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr13_-_67755192 2.819 ENSMUST00000144183.1
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr16_-_74411292 2.801 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr4_-_108032069 2.764 ENSMUST00000106709.2
 Podn
podocan
chr12_+_11265867 2.714 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr10_+_13966268 2.703 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr5_+_88886809 2.571 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr11_+_78499087 2.537 ENSMUST00000017488.4
 Vtn
vitronectin
chr7_-_78577771 2.505 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr19_-_5797410 2.428 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 208 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 8.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 7.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.0 6.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 4.5 GO:0060612 adipose tissue development(GO:0060612)
0.8 4.2 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2 4.1 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 3.6 GO:0061157 mRNA destabilization(GO:0061157)
0.8 3.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.0 3.1 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.8 3.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 2.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 2.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 2.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 2.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.6 GO:0006491 N-glycan processing(GO:0006491)
0.8 2.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.5 2.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 2.5 GO:0097421 liver regeneration(GO:0097421)
0.1 2.5 GO:0035455 response to interferon-alpha(GO:0035455)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 9.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 7.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 6.0 GO:0030673 axolemma(GO:0030673)
0.6 3.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 3.4 GO:0031673 H zone(GO:0031673)
0.1 3.0 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.9 2.7 GO:0035061 interchromatin granule(GO:0035061)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 2.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 2.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.6 2.2 GO:0090537 CERF complex(GO:0090537)
0.1 2.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.0 GO:0016528 sarcoplasm(GO:0016528)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 10.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 7.9 GO:0030507 spectrin binding(GO:0030507)
0.7 6.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.0 4.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 4.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 4.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 3.7 GO:0005518 collagen binding(GO:0005518)
0.6 3.0 GO:0045545 syndecan binding(GO:0045545)
0.2 3.0 GO:0001846 opsonin binding(GO:0001846)
0.6 2.9 GO:0016972 thiol oxidase activity(GO:0016972)
0.1 2.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.5 2.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 2.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 2.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.3 2.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.7 2.2 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 2.2 GO:0017091 AU-rich element binding(GO:0017091)
0.5 2.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 6.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 3.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 3.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 3.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 3.1 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.4 2.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.6 1.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 7.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 5.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 3.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 3.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.6 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 2.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.3 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 2.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.6 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.6 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis